Mechanical signatures in cancer metastasis

npj Biological Physics and Mechanics., Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 4, 2025

Abstract The cancer metastatic cascade includes a series of mechanical barrier-crossing events, involving the physical movement cells from their primary location to distant organ. This review describes changes that influence tumour proliferation, progression, and metastasis. We identify potential signatures at every step discuss some latest mechanobiology-based therapeutic interventions highlight importance interdisciplinary approaches in diagnosis treatment.

Язык: Английский

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The Pentose Phosphate Pathway: From Mechanisms to Implications for Gastrointestinal Cancers

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 610 - 610

Опубликована: Янв. 13, 2025

The pentose phosphate pathway (PPP), traditionally recognized for its role in generating nicotinamide adenine dinucleotide (NADPH) and ribose-5-phosphate (R5P), has emerged as a critical metabolic hub with involvements various gastrointestinal (GI) cancers. PPP plays crucial roles the initiation, development, tumor microenvironment (TME) of GI cancers by modulating redox homeostasis providing precursors nucleotide biosynthesis. Targeting enzymes their regulatory axis been potential strategy anti-GI cancer therapies. In this review, we summarize mechanisms enzymes, elucidate relationships between TME's elements, discuss therapeutic targeting

Язык: Английский

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Cancer-associated fibroblasts: Key criminals of tumor pre-metastatic niche

Cancer Letters, Год журнала: 2023, Номер 566, С. 216234 - 216234

Опубликована: Май 24, 2023

Cancer-associated fibroblasts (CAFs) are abundant and important components of the tumour mesenchyme, have been extensively studied for their role in primary tumours. CAFs provide biomechanical support cells play key roles immunosuppression metastasis. can promote epithelial-mesenchymal transition (EMT) by secreting extracellular vesicles (EVs), increasing adhesion to cells, remodelling matrix (ECM) tumour, changing its mechanical stiffness, which provides a pathway Moreover, form cell clusters with circulating (CTCs) help them resist blood shear forces achieve colonisation distant host organs. Recent studies revealed pre-metastatic niche (PMN) formation prevention. In this review, we discuss PMN therapeutic interventions targeting prevent

Язык: Английский

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Engine shutdown: migrastatic strategies and prevention of metastases

Trends in cancer, Год журнала: 2023, Номер 9(4), С. 293 - 308

Опубликована: Фев. 15, 2023

Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the machinery has been shown promote metastatic dissemination, successful migrastatic therapy may reduce need for high-dose cytotoxic therapies that currently used risk dissemination. In this review we focus on anti-invasive antimetastatic hold promise treatment tumors. The best targets would be those required motility, such as ATP availability, mitochondrial metabolism, cytoskeletal dynamics contractility.

Язык: Английский

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Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Май 28, 2023

Tumor suppressor p53 can transcriptionally activate downstream genes in response to stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis, other biological responses. has seven functional domains 12 splice isoforms, different subtypes play roles. The activation inactivation of are finely regulated associated with phosphorylation/acetylation modification ubiquitination modification, respectively. Abnormal is closely related occurrence development cancer. While targeted therapy signaling pathway still its early stages only a few drugs or treatments have entered clinical trials, new ongoing trials expected lead widespread use signaling-targeted cancer treatment future. TRIAP1 novel inhibitor apoptosis. homolog yeast mitochondrial intermembrane protein MDM35, which tumor-promoting role by blocking mitochondria-dependent apoptosis pathway. This work provides systematic overview recent basic research progress proposes that an important therapeutic target signaling.

Язык: Английский

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Blebology: principles of bleb-based migration

Trends in Cell Biology, Год журнала: 2024, Номер 34(10), С. 838 - 853

Опубликована: Март 27, 2024

Язык: Английский

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Immunosurveillance encounters cancer metabolism

EMBO Reports, Год журнала: 2024, Номер 25(2), С. 471 - 488

Опубликована: Янв. 12, 2024

Abstract Tumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, redox demands. Similarly, processes in immune support host immunity against cancer determine differentiation fate of leukocytes. Thus, deregulation imbalance within the tumor microenvironment have been reported drive evasion compromise therapeutic outcomes. Interestingly, emerging evidence indicates that anti-tumor could modulate heterogeneity, aggressiveness, reprogramming, suggesting immunosurveillance can instruct progression multiple dimensions. This review summarizes our current understanding how crosstalk tumors affects immunogenicity promotes progression. Furthermore, we explain defects cascade contribute developing dysfunctional responses cancers discuss contribution these as a feedback mechanism. Finally, highlight ongoing clinical trials new strategies targeting cellular metabolism cancer.

Язык: Английский

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Obesity, Dietary Fats, and Gastrointestinal Cancer Risk-Potential Mechanisms Relating to Lipid Metabolism and Inflammation

Metabolites, Год журнала: 2024, Номер 14(1), С. 42 - 42

Опубликована: Янв. 10, 2024

Obesity is a major driving factor in the incidence, progression, and poor treatment response gastrointestinal cancers. Herein, we conducted comprehensive analysis of impact obesity its resulting metabolic perturbations across four cancer types, namely, oesophageal, gastric, liver, colorectal cancer. Importantly, not all obese phenotypes are equal. Obese adipose tissue heterogeneity depends on location, structure, cellular profile (including resident immune cell populations), dietary fatty acid intake. We discuss whether impacts tumorigenic environment. Dietary fat quality, particular saturated acids, promotes hypertrophic, pro-inflammatory profile, contrast to monounsaturated hyperplastic, less inflammatory phenotype. The purpose this review examine obesity, including biology oncogenesis, specifically focusing lipid metabolism mechanisms. This achieved with focus cancers as exemplar models obesity-associated

Язык: Английский

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Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Март 8, 2025

Epigenomic modifications—such as DNA methylation, histone acetylation, and methylation—and their implications in tumorigenesis, progression, treatment have emerged a pivotal field cancer research. Tumors undergo metabolic reprogramming to sustain proliferation metastasis nutrient-deficient conditions, while suppressing anti-tumor immunity the tumor microenvironment (TME). Concurrently, immune cells within immunosuppressive TME adaptations, leading alterations function. The complicated interplay between metabolites epigenomic modulation has spotlighted significance of regulation immunometabolism. In this review, characteristics modification associated with tumors are systematically summarized alongside regulatory roles Classical emerging approaches delineated broaden boundaries research on crosstalk immunometabolism epigenomics. Furthermore, we discuss potential therapeutic strategies that target modulate modifications, highlighting burgeoning synergy therapies immunotherapy promising avenue for treatment.

Язык: Английский

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The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane

Development, Год журнала: 2023, Номер 150(9)

Опубликована: Апрель 11, 2023

ABSTRACT Cell invasion through basement membrane (BM) barriers is important in development, immune function and cancer progression. As BM often stochastic, capturing gene expression profiles of actively invading cells vivo remains elusive. Using the stereotyped timing Caenorhabditis elegans anchor cell (AC) invasion, we generated an AC transcriptome during breaching. Through a focused RNAi screen transcriptionally enriched genes, identified new regulators, including translationally controlled tumor protein (TCTP). We also discovered enrichment ribosomal proteins. AC-specific RNAi, endogenous ribosome labeling biogenesis analysis revealed that burst production occurs shortly after specification, which drives translation proteins mediating removal. Ribosomes enrich near endoplasmic reticulum (ER) Sec61 translocon endomembrane system expands before invasion. show sensitive to ER stress, indicating heightened requirement for ER-trafficked These studies reveal key roles expansion establish as resource identify mechanisms underlying transmigration.

Язык: Английский

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