Aging,
Год журнала:
2023,
Номер
15(22), С. 12952 - 12965
Опубликована: Ноя. 16, 2023
Colorectal
cancer
is
one
of
the
most
common
malignant
tumors
in
digestive
system,
and
its
high
incidence
metastasis
rate
make
it
a
terrible
killer
that
threatens
human
health.
In-depth
exploration
targets
affecting
progression
colorectal
cells
development
specific
targeted
drugs
for
them
are
great
significance
prognosis
patients.
Erythropoietin-producing
hepatocellular
A2
(EphA2)
member
Eph
subfamily
with
tyrosine
kinase
activity,
plays
key
role
regulation
signaling
pathways
related
to
phenotype
various
tumor
cells,
but
regulatory
mechanism
needs
be
further
clarified.
Here,
we
found
EphA2
was
abnormally
highly
expressed
patients
expression
had
worse
prognosis.
We
also
can
form
liquid-liquid
phase
separation
condensates
on
cell
membrane,
which
disrupted
by
ALW-II-41-27,
an
inhibitor
EphA2.
In
addition,
positively
correlated
ferroptosis-related
genes
infiltration
multiple
immune
cells.
These
findings
suggest
novel
membrane
protein
ability
associated
ferroptosis
infiltration,
suggests
may
inhibited
suppressing
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 13804 - 13804
Опубликована: Сен. 7, 2023
The
heat
shock
factor
1
(HSF1)-mediated
stress
response
pathway
and
autophagy
processes
play
important
roles
in
the
maintenance
of
proteostasis.
Autophagy
are
subdivided
into
three
subtypes:
macroautophagy,
chaperone-mediated
(CMA),
microautophagy.
Recently,
molecular
chaperones
co-factors
were
shown
to
be
involved
selective
degradation
substrates
by
these
processes.
This
evidence
suggests
that
regulated
a
coordinated
manner
HSF1-mediated
pathway.
various
studies
have
demonstrated
proteostasis
pathways
including
HSF1
implicated
longevity.
Furthermore,
they
serve
as
therapeutic
targets
for
aging-related
diseases
such
cancer
neurodegenerative
diseases.
In
future,
will
underpin
development
therapies
against
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 23, 2024
Lung
cancer
is
the
leading
cause
of
global
cancer-related
deaths.
Platinum-based
chemotherapy
first-line
treatment
for
most
common
type
lung
cancer,
i.e.,
non-small-cell
(NSCLC),
but
its
therapeutic
efficiency
limited
by
chemotherapeutic
resistance.
Therefore,
it
vital
to
develop
effective
modalities
that
bypass
molecular
mechanisms
associated
with
Ferroptosis
a
form
non-apoptotic
regulated
cell
death
characterized
iron-dependent
lipid
peroxidation
(LPO).
crucial
proper
efficacy
cancer-associated
chemotherapies.
If
targeted
as
novel
mechanism,
ferroptosis
modulators
present
new
opportunities
increasing
chemotherapy.
Emerging
studies
have
revealed
pharmacological
induction
using
natural
compounds
boosts
in
or
drug-resistant
cancer.
In
this
review,
we
first
discuss
resistance
(or
chemoresistance)
and
introduce
core
behind
ferroptosis.
Then,
comprehensively
summarize
small-molecule
sourced
from
traditional
medicines
may
boost
anti-tumor
activity
current
agents
overcome
NSCLC.
Cumulatively,
suggest
ferroptosis-related
anticancer
could
serve
starting
point
NSCLC
inducing
ferroptosis,
highlighting
potential
regimens
used
chemoresistance
Biological Procedures Online,
Год журнала:
2024,
Номер
26(1)
Опубликована: Май 27, 2024
Abstract
Exosomes
are
increasingly
recognized
as
important
mediators
of
intercellular
communication
in
cancer
biology.
can
be
derived
from
cells
well
cellular
components
tumor
microenvironment.
After
secretion,
the
exosomes
carrying
a
wide
range
bioactive
cargos
ingested
by
local
or
distant
recipient
cells.
The
released
act
through
variety
mechanisms
to
elicit
multiple
biological
effects
and
impact
most
if
not
all
hallmarks
cancer.
Moreover,
owing
their
excellent
biocompatibility
capability
being
easily
engineered
modified,
currently
exploited
promising
platform
for
targeted
therapy.
In
this
review,
we
first
summarize
current
knowledge
roles
risk
etiology,
initiation
progression
cancer,
underlying
molecular
mechanisms.
aptamer-modified
exosome
therapy
is
then
briefly
introduced.
We
also
discuss
future
directions
emerging
biology
perspective
Aging,
Год журнала:
2023,
Номер
15(22), С. 12952 - 12965
Опубликована: Ноя. 16, 2023
Colorectal
cancer
is
one
of
the
most
common
malignant
tumors
in
digestive
system,
and
its
high
incidence
metastasis
rate
make
it
a
terrible
killer
that
threatens
human
health.
In-depth
exploration
targets
affecting
progression
colorectal
cells
development
specific
targeted
drugs
for
them
are
great
significance
prognosis
patients.
Erythropoietin-producing
hepatocellular
A2
(EphA2)
member
Eph
subfamily
with
tyrosine
kinase
activity,
plays
key
role
regulation
signaling
pathways
related
to
phenotype
various
tumor
cells,
but
regulatory
mechanism
needs
be
further
clarified.
Here,
we
found
EphA2
was
abnormally
highly
expressed
patients
expression
had
worse
prognosis.
We
also
can
form
liquid-liquid
phase
separation
condensates
on
cell
membrane,
which
disrupted
by
ALW-II-41-27,
an
inhibitor
EphA2.
In
addition,
positively
correlated
ferroptosis-related
genes
infiltration
multiple
immune
cells.
These
findings
suggest
novel
membrane
protein
ability
associated
ferroptosis
infiltration,
suggests
may
inhibited
suppressing
