Towards load-bearing biomedical titanium-based alloys: From essential requirements to future developments

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101277 - 101277

Опубликована: Март 8, 2024

The use of biomedical metallic materials in research and clinical applications has been an important focus a significant area interest, primarily owing to their role enhancing human health extending lifespan. This article, particularly on titanium-based alloys, explores exceptional properties that can address bone issues amid the growing challenges posed by aging population. Although stainless steel, magnesium-based cobalt-based other are commonly employed medical applications, limitations such as toxic elements, high elastic modulus, rapid degradation rates limit widespread applications. Therefore, alloys have emerged top-performing materials, gradually replacing counterparts various article extensively examines highlights along with in-depth discussion currently utilized inherent limitations. To begin with, essential requirements for load-bearing biomaterials introduced. Then, summarized compared. Afterward, microstructure, properties, preparations explored. Furthermore, surface modification methods discussed enhance biocompatibility, wear resistance corrosion resistance. Finally, proposes development path conjunction additive manufacturing novel alloy nitinol.

Язык: Английский

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Degradation of Xenobiotic Pollutants: An Environmentally Sustainable Approach

Metabolites, Год журнала: 2022, Номер 12(9), С. 818 - 818

Опубликована: Авг. 31, 2022

The ability of microorganisms to detoxify xenobiotic compounds allows them thrive in a toxic environment using carbon, phosphorus, sulfur, and nitrogen from the available sources. Biotransformation is most effective useful metabolic process degrade compounds. Microorganisms have an exceptional due particular genes, enzymes, degradative mechanisms. such as bacteria fungi unique properties that enable partially or completely metabolize substances various ecosystems.There are many cutting-edge approaches understand molecular mechanism processes pathways decontaminate change core structure xenobiotics nature. These methods examine microorganisms, their machinery, novel proteins, catabolic genes. This article addresses recent advances current trends characterize enzymes techniques involved combating threat eco-friendly approach.

Язык: Английский

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Comprehensive, Quantitative Analysis of SRM 1950: the NIST Human Plasma Reference Material

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Many analytical methods have been developed for performing targeted metabolomics. By combining multiple techniques, comprehensive coverage of the metabolome can be achieved. We combined techniques to comprehensively and quantitatively characterize widely studied NIST human plasma reference material, SRM 1950. Our goal was provide a large, well-validated list confident metabolite concentration values (i.e., benchmarks) assist metabolomics community in its calibration comparison efforts. used four platforms: high-resolution NMR spectroscopy, direct injection tandem MS (DI-MS/MS), liquid chromatography (LC-MS/MS), inductively coupled (ICP-MS). Eight validated assays were run, yielding accurate quantitative measurements 728 unique metabolites or species. Through computer-aided literature mining, we identified another 330 previously quantified compared NIST-certified along with literature-derived concentrations/ranges concentrations measured by our platforms eight assays. From these assays/platforms, generated high-confidence 1058 species 1950 including data 60 amino acids/related compounds, 48 bile acids, 72 amines/sugars/alcohols, 21 metals, 8 catecholamines, 11 vitamins, 92 organic 40 fatty acids/steroids/nucleobases/indole derivatives, 5 polyfluorinated 7 carotenoids, 39 acylcarnitines, 76 oxylipins, 13 sterols, 566 lipids/lipid This set represents most complete characterization An online database (SRM1950-DB) containing metabolites/metabolite 1950, their structures, HMDB IDs, mass, chemical class, concentrations, references, reliability is freely available at https://srm1950-data.wishartlab.com.

Язык: Английский

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Effects of microplastics and arsenic on plants: Interactions, toxicity and environmental implications

Chemosphere, Год журнала: 2023, Номер 338, С. 139542 - 139542

Опубликована: Июль 18, 2023

Язык: Английский

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Sample preparation strategies for mass spectrometry analysis in human exposome research: Current status and future perspectives

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 166, С. 117151 - 117151

Опубликована: Июнь 24, 2023

The exposome is the measure of total environmental exposures and has a significant impact on human health outcomes. Exposomics research typically examines complex biological samples assesses 100s to 1,000s small molecules associated with chemical exposure events. To acquire robust comprehensive datasets encompassing broad range multi-class biomarkers exposures, high-resolution tandem mass spectrometry have emerged as preferred analytical tools in field. Due matrix effects interferences together presence very low abundance analytes, sensitivity reproducibility plagued exposomic studies. This especially true for large sample sets where adequate robustness frequently lacking. A possible solution this problem development non-discriminatory preparation methods which can reduce while increasing reproducibility. However, techniques intrinsically result discrete loss analytes leading outstanding challenge finding proper balance. Therefore, approaches decrease preserving coverage need be developed. In review, procedures currently applied related fields are summarized critically evaluated. includes comparison advantages limitations between different such solid-phase extraction, liquid QuEChERS, filters dilute shoot chromatography-mass analysis focus. Based evaluation, recommendations promoting balanced strategies future applications provided.

Язык: Английский

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Understanding PFAS toxicity through cell culture metabolomics: Current applications and future perspectives

Environment International, Год журнала: 2024, Номер 186, С. 108620 - 108620

Опубликована: Апрель 1, 2024

Per- and polyfluoroalkyl substances (PFAS), ubiquitous environmental contaminants, pose significant challenges to ecosystems human health. While cell cultures have emerged as new approach methodologies (NAMs) in ecotoxicity research, metabolomics is an emerging technique used characterize the small-molecule metabolites present cells understand their role various biological processes. Integration of with cultures, known culture metabolomics, provides a novel robust tool unravel complex molecular responses induced by PFAS exposure. In vitro testing also reduces reliance on animal testing, aligning ethical regulatory imperatives. The current review summarizes key findings from recent studies utilizing investigate toxicity, highlighting alterations metabolic pathways, biomarker identification, potential linkages between perturbations. Additionally, paper discusses different types methods for contaminants particularly PFAS. Future perspectives combination other advanced technologies, such single-cell (SCM), imaging mass spectrometry (IMS), extracellular flux analysis (EFA), multi-omics are explored, which offers holistic understanding contaminants. synthesis knowledge identification research gaps provide foundation future investigations that aim elucidate complexities PFAS-induced cellular contribute development effective strategies mitigating adverse effects

Язык: Английский

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Cities, communities and clinics can be testbeds for human exposome and aging research

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

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Persistence of algal toxicity induced by polystyrene nanoplastics at environmentally relevant concentrations

The Science of The Total Environment, Год журнала: 2023, Номер 876, С. 162853 - 162853

Опубликована: Март 14, 2023

Язык: Английский

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Roadmap for the integration of environmental microbiomes in risk assessments under EFSA's remit

EFSA Supporting Publications, Год журнала: 2024, Номер 21(2)

Опубликована: Фев. 1, 2024

Scientific interest in the use of environmental microbiomes for risk assessment is rapidly growing, as exemplified by various EFSA opinions. In absence official regulatory guidelines on how to integrate assessment, aims this report are therefore determine whether microbiome studies can be used such purposes, and propose a roadmap integration assessments under EFSA's remit. The identifies current gaps (in terms knowledge from technical point view) barriers that might delay implementation methods, offers recommendations standardised (multi-)omics techniques purposes. Our main findings identified five priorities: (i) defining core (what it encompasses what made of, including identification bioindicators) assess impact any type disturbance; (ii) standardising methodologies protocols, sampling interpretation, guarantee comparability analyses; (iii) developing tools facilitate interpretation; (iv) collecting microbiome-based data shared, curated maintained databases; (v) setting up European Network Microbiome Laboratories reach an agreement standardise studies, interactions between researchers access or samples, actively include multiple stakeholders discussions involving assessment. There both short- longer-term priorities, all which highlight need mobilise concurrently different agencies institutions, well research. also points out capacity building training, acceptance emerging technology, communication issues. These will hopefully contribute elaboration widely accepted framework dealing with.

Язык: Английский

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Biogas slurry reflux enhances the organic loading rate of high-solid anaerobic digestion of kitchen waste by alleviating fatty acids accumulation

Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 149072 - 149072

Опубликована: Янв. 26, 2024

Язык: Английский

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