Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 17, 2025
Colorectal
cancer
(CRC)
is
one
of
the
most
prevalent
cancers
in
terms
diagnosis
and
mortality.
Radiotherapy
(RT)
remains
a
mainstay
CRC
therapy.
As
RT
relies
on
DNA
damage
to
promote
tumor
cell
death,
activity
cellular
repair
pathways
can
modulate
sensitivity
The
gut
microbiome
has
been
shown
influence
intestinal
health
independently
associated
with
development,
treatment
responses
outcomes.
also
through
various
mechanisms
such
as
community
structure,
toxins
metabolites.
In
this
review
we
explore
use
molecular
factors
that
We
discuss
how
radiosensitivity
versus
radioprotection
outcomes
CRC.
Understanding
interaction
between
assist
predicting
RT.
Once
described,
these
connections
response
be
used
identify
actionable
targets
for
therapeutic
development.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 10, 2024
Glioblastoma
(GBM)
is
a
highly
malignant,
invasive,
and
poorly
prognosed
brain
tumor.
Unfortunately,
active
comprehensive
treatment
does
not
significantly
prolong
patient
survival.
With
the
deepening
of
research,
it
has
been
found
that
gut
microbiota
plays
certain
role
in
GBM,
can
directly
or
indirectly
affect
efficacy
immune
checkpoint
inhibitors
(ICIs)
various
ways.
(1)
The
metabolites
produced
by
host’s
homeostasis,
these
function
distribution
cells,
promote
inhibit
inflammatory
responses,
phenotype,
angiogenesis,
response,
cell
infiltration
GBM
thereby
affecting
effectiveness
ICIs.
(2)
Some
members
may
reverse
T
inhibition,
increase
anti-tumor
activity,
ultimately
improve
ICIs
targeting
specific
immunosuppressive
cytokines.
(3)
participate
metabolic
process
drugs,
which
degrade,
transform,
produce
metabolites,
effective
concentration
bioavailability
drugs.
Optimizing
structure
help
(4)
also
regulate
status
through
axis
communication,
progression
therapeutic
response
to
(5)
Given
importance
for
ICI
therapy,
researchers
have
begun
exploring
use
fecal
transplantation
(FMT)
transplant
healthy
optimized
patients,
order
their
enhance
therapy.
Preliminary
studies
suggest
FMT
therapy
some
patients.
In
summary,
crucial
regulating
with
deeper
understanding
relationship
between
tumor
immunity,
expected
develop
more
precise
personalized
strategies
prognosis.
npj Science of Food,
Год журнала:
2025,
Номер
9(1)
Опубликована: Апрель 14, 2025
Radiotherapy,
a
widely
employed
cancer
treatment,
often
triggers
diverse
inflammatory
responses
such
as
radiation
enteritis,
pulmonary
injury,
pelvic
inflammation,
dermatitis,
and
osteitis.
Dietary
polyphenols
have
recently
emerged
promising
agents
for
mitigating
radiation-induced
inflammation.
However,
their
clinical
application
faced
challenges
related
to
variable
bioavailability,
individual
pharmacokinetics,
optimal
dosing,
limited
evidence.
Current
researches
revealed
the
efficacy
of
bioactive
small
molecule
in
addressing
In
this
review,
along
with
comprehensive
examination
etiology
categories
conditions,
diversity
elucidating
anti-inflammatory
mechanisms
are
explored.
This
study
emphasizes
recent
progresses
delivery
systems
dietary
polyphenols,
aiming
enhance
radioprotection
effects.
The
optimized
utilization
theoretical
framework
reference
guide,
is
paramount
relevance.
Through
mechanisms,
more
effective
safer
radioprotective
strategies
become
achievable.
endeavor
aspires
contribute
breakthroughs
polyphenols'
application,
significantly
enhancing
human
health
protection
during
radiotherapy.
These
insights
presented
here
also
support
(pre)-clinical
practices
navigating
complexities
utilizing
radioprotection,
fostering
advancements
field
improving
patient
outcomes.
International Journal of Radiation Oncology*Biology*Physics,
Год журнала:
2024,
Номер
120(1), С. 189 - 204
Опубликована: Март 12, 2024
PurposeRadiation-induced
intestinal
injury
(RIII)
commonly
occur
during
abdominal-pelvic
cancer
radiation
therapy;
however,
no
effective
prophylactic
or
therapeutic
agents
are
available
to
manage
RIII
currently.
This
study
aimed
clarify
the
potential
of
probiotic
consortium
supplementation
in
alleviating
RIII.Methods
and
MaterialsMale
C57BL/6J
mice
were
orally
administered
a
mixture
comprising
Bifidobacterium
longum
BL21,
Lactobacillus
paracasei
LC86,
plantarum
Lp90
for
30
days
before
exposure
13
Gy
whole
abdominal
irradiation.
The
survival
rates,
clinical
scores,
histologic
changes
intestines
assessed.
impacts
treatment
on
stem
cell
proliferation,
differentiation,
epithelial
barrier
function;
oxidative
stress;
inflammatory
cytokines
evaluated.
A
comprehensive
examination
gut
microbiota
composition
was
conducted
through
16S
rRNA
sequencing,
while
metabolites
identified
using
liquid
chromatography-mass
spectrometry.ResultsThe
alleviated
RIII,
as
reflected
by
increased
improved
mitigated
mucosal
injury.
exhibited
enhanced
effects
at
level
compared
with
individual
strains,
although
there
corresponding
improvement
rates
colon
length.
Moreover,
stimulated
proliferation
integrity
barrier,
regulated
redox
imbalance
responses
irradiated
mice.
Notably,
induced
restructuring
composition,
particularly
enriching
short-chain
fatty
acid-producing
bacteria.
Metabolomic
analysis
revealed
distinctive
metabolic
associated
consortium,
including
elevated
levels
anti-inflammatory
antiradiation
metabolites.ConclusionsThe
attenuated
modulating
metabolites,
improving
symptoms,
regulating
stress.
These
findings
provide
new
insights
into
maintenance
health
will
facilitate
development
probiotic-based
strategies
practice.
Radiation-induced
RIII.
Male
spectrometry.
metabolites.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 30, 2024
Abstract
Radiation
colitis
is
one
of
the
most
common
complications
in
patients
undergoing
pelvic
radiotherapy
and
there
no
effective
treatment
clinic.
Therefore,
searching
for
agents
radiation
urgently
needed.
Herein,
it
found
that
essential
element
selenium
(Se)
protective
against
through
inhibiting
X‐ray‐induced
apoptosis,
cell
cycle
arrest,
inflammation
with
involvement
balancing
generation
reactive
oxygen
species
after
irradiation.
Mechanistically,
Se,
especially
nanoparticles
(SeNPs),
induced
selenoprotein
expression
then
functioned
to
effectively
restrain
DNA
damage
response,
which
reduced
intestinal
injury.
Additionally,
SeNPs
also
restrained
cyclic
GMP‐AMP
synthas
(cGAS)‐
stimulator
interferon
genes
(STING)‐TBK1‐IRF3
signaling
pathway
cascade,
thereby
blocking
transcription
inflammatory
cytokine
gene,
IL‐6
TNF‐α,
thus
alleviating
inflammation.
Moreover,
inducing
expression,
such
as
GPX4,
vivo
can
regulate
microenvironment
immunity
gut
microbiota
attenuate
radiation‐induced
by
oxidative
stress
maintaining
homeostasis.
Together,
these
results
unravel
a
previously
unidentified
modulation
role
but
suppressing
cGAS‐STING‐TBK1‐IRF3
cascade.
Radiation-induced
tissue
injury
(RITI)
is
the
most
common
complication
in
clinical
tumor
radiotherapy.
Due
to
heterogeneity
response
of
different
tissues
radiation
(IR),
radiotherapy
will
cause
types
and
degrees
RITI,
which
greatly
limits
application
Efforts
are
continuously
ongoing
elucidate
molecular
mechanism
RITI
develop
corresponding
prevention
treatment
drugs
for
RITI.
Single-cell
sequencing
(Sc-seq)
has
emerged
as
a
powerful
tool
uncovering
mechanisms
identifying
potential
targets
by
enhancing
our
understanding
complex
intercellular
relationships,
facilitating
identification
novel
cell
phenotypes,
allowing
assessment
spatiotemporal
developmental
trajectories.
Based
on
comprehensive
review
we
analyzed
regulatory
networks
combination
with
Sc-seq
summarized
targeted
intervention
pathways
therapeutic
Deciphering
diverse
underlying
can
shed
light
its
pathogenesis
unveil
new
avenues
potentially
facilitate
repair
or
regeneration
currently
irreversible
Furthermore,
discuss
how
personalized
strategies
based
offer
promise
mitigating
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Окт. 10, 2024
Radiotherapy
is
a
pivotal
intervention
for
cancer
patients,
significantly
impacting
their
treatment
outcomes
and
survival
prospects.
Nevertheless,
in
the
course
of
treating
those
with
abdominal,
pelvic,
or
retroperitoneal
malignant
tumors,
procedure
inadvertently
exposes
adjacent
intestinal
tissues
to
radiation,
posing
risks
radiation-induced
enteropathy
upon
reaching
threshold
doses.
Stem
cells
within
crypts,
through
controlled
proliferation
differentiation,
support
critical
functions
epithelium,
ensuring
efficient
nutrient
absorption
while
upholding
its
protective
barrier
properties.
Intestinal
stem
(ISCs)
regulation
intricately
orchestrated
by
diverse
signaling
pathways,
among
which
are
WNT,
BMP,
NOTCH,
EGF,
Hippo,
Hedgehog
NF-κB,
each
contributing
complex
control
these
cells'
behavior.
Complementing
pathways
additional
regulators
such
as
metabolic
states,
microbiota,
all
contribute
fine-tuning
ISCs
behavior
crypts.
It
harmonious
interplay
cascades
modulating
elements
that
preserves
homeostasis
epithelial
(IECs),
thereby
gut's
overall
health
function.
This
review
delves
into
molecular
underpinnings
how
respond
context
radiation
enteropathy,
aiming
illuminate
potential
biological
targets
therapeutic
intervention.
Furthermore,
we
have
compiled
summary
several
current
methodologies.
By
unraveling
mechanisms
methods,
aspire
furnish
roadmap
development
novel
therapeutics,
advancing
our
capabilities
mitigating
damage.
Life Sciences,
Год журнала:
2024,
Номер
353, С. 122921 - 122921
Опубликована: Июль 18, 2024
Pelvic
irradiation,
a
crucial
treatment
for
pelvic
malignancies,
is
associated
with
the
risk
of
gastrointestinal
(GI)
damage
due
to
high
proliferation
rate
epithelial
cells.
The
radiosensitive
tract
acts
as
dose-limiting
organ.
High
doses
ionizing
radiation
can
cause
inflammation
and
rupture
mucosal
barriers
also
lead
intestinal
fibrosis.
Intestinal
acute
chronic
complications,
reducing
patients'
quality
life.
gut
microbiota
plays
vital
role
in
maintaining
health,
any
changes
microbial
composition
worsen
damage,
emphasizing
importance
therapies
that
target
sustain
during
radiotherapy.
One
potential
strategy
prevent
radiation-induced
GI
use
bacterial
supplements.
Research
suggests
probiotic
supplementation
may
alleviate
morphology
decreasing
injury
cancer
patients.
observed
protective
effects
occur
through
various
mechanisms,
including
antioxidant
activities,
modulation
immune
response,
preservation
barrier
function.
To
optimize
therapies,
it
imperative
elucidate
these
mechanisms.
efficiency
probiotics
radioprotectors
highly
dependent
on
time
dose
administration,
their
interaction
host
system
key
facet
therapeutic
potential.
This
review
explores
benefits
mitigating
underlying
mechanism.
highlights
need
further
research
establish
standardized
protocols
refine
strategies,
underscoring
enhancing
outcomes
patients
undergoing
