Biomaterials Advances, Год журнала: 2024, Номер unknown, С. 214144 - 214144
Опубликована: Дек. 1, 2024
Язык: Английский
Nature Cell Biology, Год журнала: 2024, Номер 26(5), С. 674 - 686
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
19
Pharmacological Research, Год журнала: 2024, Номер 209, С. 107434 - 107434
Опубликована: Сен. 25, 2024
Mitochondria are crucial organelles that regulate cellular energy metabolism, calcium homeostasis, and oxidative stress responses, playing pivotal roles in brain development neurodegeneration. Concurrently, the gut microbiota has emerged as a key modulator of physiology pathology through microbiota-gut-brain axis. Recent evidence suggests an intricate crosstalk between mitochondrial function, mediated by microbial metabolites can influence activities brain. This review aims to provide comprehensive overview emerging role mitochondria critical mediators axis, shaping health neurological disease pathogenesis. We discuss how such short-chain fatty acids, secondary bile tryptophan metabolites, trimethylamine N-oxide traverse blood-brain barrier modulate processes including production, regulation, mitophagy, neurons glial cells. Additionally, we proposed targeting diet, prebiotics, probiotics, or promising potential therapeutic approach maintain optimizing fitness. Overall, further investigations into its bioenergetics, dynamics, responses will valuable insights axis both states.
Язык: Английский
Процитировано
13
Journal of Biological Chemistry, Год журнала: 2023, Номер 300(1), С. 105470 - 105470
Опубликована: Ноя. 22, 2023
The prevailing notion that reduced cofactors NADH and FADH
Язык: Английский
Процитировано
23
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 283, С. 109975 - 109975
Опубликована: Июль 6, 2024
Язык: Английский
Процитировано
9
Development, Год журнала: 2023, Номер 150(20)
Опубликована: Окт. 15, 2023
Metabolic switches are a crucial hallmark of cellular development and regeneration. In response to changes in their environment or physiological state, cells undergo coordinated metabolic switching that is necessary execute biosynthetic demands growth repair. this Review, we discuss how represent an evolutionarily conserved mechanism orchestrates tissue regeneration, allowing adapt rapidly changing conditions during postnatally. We further explore the dynamic interplay between metabolism it not only output, but also driver functions, such as cell proliferation maturation. Finally, underscore epigenetic mechanisms by which mediate needs understanding these important for advancing our knowledge devising new strategies promote
Язык: Английский
Процитировано
14
Cell stem cell, Год журнала: 2024, Номер 31(4), С. 570 - 581.e7
Опубликована: Март 22, 2024
Язык: Английский
Процитировано
6
iScience, Год журнала: 2024, Номер 27(6), С. 109874 - 109874
Опубликована: Май 3, 2024
Mitochondrial division controls the size, distribution, and turnover of this essential organelle. A dynamin-related GTPase, Drp1, drives membrane as a force-generating mechano-chemical enzyme. Drp1 is regulated by multiple mechanisms, including phosphorylation at two primary sites: serine 579 600. While previous studies in cell culture systems have shown that S579 promotes mitochondrial division, its physiological functions remained unclear. Here, we generated phospho-mimetic S579D phospho-defective S579R mice using CRISPR-Cas system. Both mouse models exhibited normal growth, development, breeding. We found highly phosphorylated brain neurons. Notably, showed decreased anxiety-like behaviors, whereas displayed increased behaviors. These findings suggest critical role for function. The thus offer valuable
Язык: Английский
Процитировано
3
Annual Review of Cell and Developmental Biology, Год журнала: 2024, Номер 40(1), С. 381 - 406
Опубликована: Июль 10, 2024
Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise new neurons glia throughout life. The largest cell niche mouse is ventricular-subventricular zone (V-SVZ) lining lateral ventricles. Adult NSCs V-SVZ coexist quiescent actively proliferating states, they exhibit a regionalized molecular identity. importance of such spatial diversity just emerging, as depending on their position within niche, distinct subtypes olfactory bulb interneurons different types glia. However, functional relevance heterogeneity still poorly understood. Here, we put into perspective findings highlighting NSC for plasticity, how body signals physiological states regulate behavior.
Язык: Английский
Процитировано
3
Cell Regeneration, Год журнала: 2025, Номер 14(1)
Опубликована: Март 7, 2025
Adult neurogenesis is a unique cellular process of the ongoing generation new neurons throughout life, which primarily occurs in subgranular zone (SGZ) dentate gyrus (DG) and subventricular (SVZ) lateral ventricle. In adult DG, newly generated granule cells from neural stem (NSCs) integrate into existing circuits, significantly contributing to cognitive functions, particularly learning memory. Recently, more studies have shown that rather than being homogeneous population identical cells, NSCs are composed multiple subpopulations differ their morphology function. this study, we provide an overview origin, regional characteristics, prototypical morphology, molecular factors contribute NSC heterogeneity. particular, discuss mechanisms underlying balance between activation quiescence NSCs. summary, review highlights deciphering heterogeneity brain challenging but critical step advancing our understanding tissue-specific brain.
Язык: Английский
Процитировано
0
Stem Cell Reports, Год журнала: 2025, Номер unknown, С. 102452 - 102452
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0