Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake DOI Open Access
Lauren N. Woodie, Lily C. Melink, Mohit Midha

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 1, 2023

Circadian desynchrony induced by shiftwork or jetlag is detrimental to metabolic health, but how synchronous/desynchronous signals are transmitted among tissues unknown. Here we report that liver molecular clock dysfunction signaled the brain via hepatic vagal afferent nerve (HVAN), leading altered food intake patterns corrected ablation of HVAN. Hepatic branch vagotomy also prevents disruptions high-fat diet feeding and reduces body weight gain. Our findings reveal a previously unrecognized homeostatic feedback signal relies on synchrony between control circadian patterns. This identifies vagus as therapeutic target for obesity in setting chrono-disruption.

Язык: Английский

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications DOI Creative Commons
Sijia He, Ziying Xu, Xianlin Han

и другие.

Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 27, 2025

Alzheimer's disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to involvement of lipid dysregulation in development AD. Nevertheless, precise lipidomic landscape and mechanistic roles lipids pathology remain poorly understood. This review aims highlight significance lipidomics lipid-targeting approaches diagnosis We summarized connection between human brain AD at both genetic species levels. briefly introduced technologies discussed potential challenges areas future advancements field for research. To elucidate central role converging multiple pathological aspects AD, we reviewed current knowledge on interplay major features, including amyloid beta, tau, neuroinflammation. Finally, assessed progresses obstacles lipid-based therapeutics proposed strategies leveraging

Язык: Английский

Процитировано

3

Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake DOI
Lauren N. Woodie, Lily C. Melink, Mohit Midha

и другие.

Science, Год журнала: 2024, Номер 386(6722), С. 673 - 677

Опубликована: Ноя. 7, 2024

Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but how synchronous desynchronous signals are transmitted among tissues unknown. We report that liver molecular clock dysfunction signaled the brain through hepatic vagal afferent nerve (HVAN), leading altered food intake patterns corrected ablation of HVAN. Hepatic branch vagotomy also prevents disruptions high-fat diet feeding and reduces body weight gain. Our findings reveal a homeostatic feedback signal relies on communication between control circadian patterns. This identifies vagus as potential therapeutic target for obesity in setting chronodisruption.

Язык: Английский

Процитировано

13

Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats DOI
Charles S. da Costa, Thiago Fernandes de Oliveira, Flávia C.F. Dos Santos

и другие.

Environmental Toxicology, Год журнала: 2024, Номер 39(9), С. 4278 - 4297

Опубликована: Май 7, 2024

Abstract Cadmium (Cd) is a heavy metal that acts as endocrine disrupting chemical (EDC). Few studies have investigated the effects of Cd exposure on metabolic dysfunctions, such type 1 and 2 diabetes mellitus (T1DM T2DM). Thus, we assessed whether subacute at occupational levels causes abnormalities in white adipose tissue (WAT), liver, pancreas, skeletal muscle. We administered cadmium chloride (CdCl ) (100 ppm drinking water for 30 days) to female rats evaluated serum organs, morphophysiology, inflammation, oxidative stress, fibrosis, gene expression. High were found serum, WAT, Cd‐exposed showed low adiposity, dyslipidemia, insulin resistance, systemic stress compared controls. reduced adipocyte size, hyperleptinemia, increased cholesterol levels, apoptosis fibrosis WAT. had liver receptor beta (IRβ) peroxisome proliferator‐activated receptor‐gamma coactivator‐1alpha (PGC1α) expression, karyomegaly, fibrosis. pancreatic islet size inflammation muscle fiber diameter IR expression inflammation. Finally, strong positive correlations observed between abnormal morphology, these data suggest impairs pancreas function, leading T1DM T2DM features other complications rats.

Язык: Английский

Процитировано

3

Cell–cell communications in the brain of hepatic encephalopathy: The neurovascular unit DOI

Kyuwan Choi,

Yena Cho,

Young Soo Chae

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123413 - 123413

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Exploring the Nodus of Treatment, the Philosophical Status of Non-pharmacologic Treatment DOI Open Access

Chi Zhao

International Journal of Homeopathy & Natural Medicines, Год журнала: 2025, Номер 11(1), С. 15 - 24

Опубликована: Фев. 20, 2025

Non-pharmacologic treatments (NPTs) based on homeopathy is being paid more and attention, but because of its lack theoretical foundation, it difficult to become the mainstream medicine. Although has a history nearly 200 years remedied shortcomings current medicine, still questioned by many people. Homeopathy actually an NPT, diluted liquid almost no medicinal component, only water in act shaking medicine bottle give people belief, patients who have effect with drug treatment benefit from treatment. Supporters believe that human body strong ability repair itself, spiritual strength occupies very important status. However, question science homeopathy, meantime also do not clarify whether scientific. High morbidity mortality are indisputable realities, careful analysis medical research theory, reason why cannot be good guide practice, withstand scrutiny philosophical deviated correct law thinking. There should place for NPTs needs supported theories principles. support theories.

Язык: Английский

Процитировано

0

Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq DOI
Ye-Jin Park, Tzu‐Chiao Lu, Tyler Jackson

и другие.

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Cardiometabolic state links neurovascular burden with brain structure and function: evidence from EEG and MRI DOI Creative Commons

Daniel Franco-O’Byrne,

Ana María Castro Laguardia, Carolina Delgado

и другие.

NeuroImage, Год журнала: 2025, Номер unknown, С. 121308 - 121308

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0

Interoception, Insula, and Autonomic Integration: Relevance to the Expression and Treatment of Psychiatric Symptoms DOI
Hugo Critchley, Joel Patchitt

Current topics in behavioral neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2

Resilience to chronic stress is characterized by circadian brain-liver coordination DOI Creative Commons
Christina Savva,

Ivan Vlassakev,

Blynn G. Bunney

и другие.

Biological Psychiatry Global Open Science, Год журнала: 2024, Номер 4(6), С. 100385 - 100385

Опубликована: Авг. 24, 2024

Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption rhythms increases the risk developing both psychiatric and metabolic disorders. To explore role chronic in modulating links between neural rhythms, we characterized transcriptional across different brain regions liver as well serum metabolomics mice exposed to social defeat stress, validated model for studying depressive-like behaviors.

Язык: Английский

Процитировано

1

Precision calories: A promising strategy for personalized health interventions in the precision nutrition framework DOI
Zhen Wang,

Luyang Wang,

Yinchen Hou

и другие.

Trends in Food Science & Technology, Год журнала: 2024, Номер unknown, С. 104727 - 104727

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1