bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 1, 2023
Circadian
desynchrony
induced
by
shiftwork
or
jetlag
is
detrimental
to
metabolic
health,
but
how
synchronous/desynchronous
signals
are
transmitted
among
tissues
unknown.
Here
we
report
that
liver
molecular
clock
dysfunction
signaled
the
brain
via
hepatic
vagal
afferent
nerve
(HVAN),
leading
altered
food
intake
patterns
corrected
ablation
of
HVAN.
Hepatic
branch
vagotomy
also
prevents
disruptions
high-fat
diet
feeding
and
reduces
body
weight
gain.
Our
findings
reveal
a
previously
unrecognized
homeostatic
feedback
signal
relies
on
synchrony
between
control
circadian
patterns.
This
identifies
vagus
as
therapeutic
target
for
obesity
in
setting
chrono-disruption.
Molecular Neurodegeneration,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 27, 2025
Alzheimer's
disease
(AD)
is
among
the
most
devastating
neurodegenerative
disorders
with
limited
treatment
options.
Emerging
evidence
points
to
involvement
of
lipid
dysregulation
in
development
AD.
Nevertheless,
precise
lipidomic
landscape
and
mechanistic
roles
lipids
pathology
remain
poorly
understood.
This
review
aims
highlight
significance
lipidomics
lipid-targeting
approaches
diagnosis
We
summarized
connection
between
human
brain
AD
at
both
genetic
species
levels.
briefly
introduced
technologies
discussed
potential
challenges
areas
future
advancements
field
for
research.
To
elucidate
central
role
converging
multiple
pathological
aspects
AD,
we
reviewed
current
knowledge
on
interplay
major
features,
including
amyloid
beta,
tau,
neuroinflammation.
Finally,
assessed
progresses
obstacles
lipid-based
therapeutics
proposed
strategies
leveraging
Science,
Год журнала:
2024,
Номер
386(6722), С. 673 - 677
Опубликована: Ноя. 7, 2024
Circadian
desynchrony
induced
by
shiftwork
or
jet
lag
is
detrimental
to
metabolic
health,
but
how
synchronous
desynchronous
signals
are
transmitted
among
tissues
unknown.
We
report
that
liver
molecular
clock
dysfunction
signaled
the
brain
through
hepatic
vagal
afferent
nerve
(HVAN),
leading
altered
food
intake
patterns
corrected
ablation
of
HVAN.
Hepatic
branch
vagotomy
also
prevents
disruptions
high-fat
diet
feeding
and
reduces
body
weight
gain.
Our
findings
reveal
a
homeostatic
feedback
signal
relies
on
communication
between
control
circadian
patterns.
This
identifies
vagus
as
potential
therapeutic
target
for
obesity
in
setting
chronodisruption.
Environmental Toxicology,
Год журнала:
2024,
Номер
39(9), С. 4278 - 4297
Опубликована: Май 7, 2024
Abstract
Cadmium
(Cd)
is
a
heavy
metal
that
acts
as
endocrine
disrupting
chemical
(EDC).
Few
studies
have
investigated
the
effects
of
Cd
exposure
on
metabolic
dysfunctions,
such
type
1
and
2
diabetes
mellitus
(T1DM
T2DM).
Thus,
we
assessed
whether
subacute
at
occupational
levels
causes
abnormalities
in
white
adipose
tissue
(WAT),
liver,
pancreas,
skeletal
muscle.
We
administered
cadmium
chloride
(CdCl
)
(100
ppm
drinking
water
for
30
days)
to
female
rats
evaluated
serum
organs,
morphophysiology,
inflammation,
oxidative
stress,
fibrosis,
gene
expression.
High
were
found
serum,
WAT,
Cd‐exposed
showed
low
adiposity,
dyslipidemia,
insulin
resistance,
systemic
stress
compared
controls.
reduced
adipocyte
size,
hyperleptinemia,
increased
cholesterol
levels,
apoptosis
fibrosis
WAT.
had
liver
receptor
beta
(IRβ)
peroxisome
proliferator‐activated
receptor‐gamma
coactivator‐1alpha
(PGC1α)
expression,
karyomegaly,
fibrosis.
pancreatic
islet
size
inflammation
muscle
fiber
diameter
IR
expression
inflammation.
Finally,
strong
positive
correlations
observed
between
abnormal
morphology,
these
data
suggest
impairs
pancreas
function,
leading
T1DM
T2DM
features
other
complications
rats.
International Journal of Homeopathy & Natural Medicines,
Год журнала:
2025,
Номер
11(1), С. 15 - 24
Опубликована: Фев. 20, 2025
Non-pharmacologic
treatments
(NPTs)
based
on
homeopathy
is
being
paid
more
and
attention,
but
because
of
its
lack
theoretical
foundation,
it
difficult
to
become
the
mainstream
medicine.
Although
has
a
history
nearly
200
years
remedied
shortcomings
current
medicine,
still
questioned
by
many
people.
Homeopathy
actually
an
NPT,
diluted
liquid
almost
no
medicinal
component,
only
water
in
act
shaking
medicine
bottle
give
people
belief,
patients
who
have
effect
with
drug
treatment
benefit
from
treatment.
Supporters
believe
that
human
body
strong
ability
repair
itself,
spiritual
strength
occupies
very
important
status.
However,
question
science
homeopathy,
meantime
also
do
not
clarify
whether
scientific.
High
morbidity
mortality
are
indisputable
realities,
careful
analysis
medical
research
theory,
reason
why
cannot
be
good
guide
practice,
withstand
scrutiny
philosophical
deviated
correct
law
thinking.
There
should
place
for
NPTs
needs
supported
theories
principles.
support
theories.
Biological Psychiatry Global Open Science,
Год журнала:
2024,
Номер
4(6), С. 100385 - 100385
Опубликована: Авг. 24, 2024
Chronic
stress
has
a
profound
impact
on
circadian
regulation
of
physiology.
In
turn,
disruption
rhythms
increases
the
risk
developing
both
psychiatric
and
metabolic
disorders.
To
explore
role
chronic
in
modulating
links
between
neural
rhythms,
we
characterized
transcriptional
across
different
brain
regions
liver
as
well
serum
metabolomics
mice
exposed
to
social
defeat
stress,
validated
model
for
studying
depressive-like
behaviors.
