Review on synthetic approaches towards barbituric acids‐based furo[2,3‐d]pyrimidines DOI
Abolfazl Olyaei, Mahdieh Sadeghpour

Journal of Heterocyclic Chemistry, Год журнала: 2023, Номер 60(11), С. 1838 - 1863

Опубликована: Июль 31, 2023

Abstract Pyrimidine annulated five‐membered heterocyclic scaffolds containing oxygen as furopyrimidine, particularly furo[2,3‐ d ]pyrimidine derivatives are an important class of compounds in pharmaceutical discovery research. Furo[2,3‐ ]pyrimidines generally synthesized either from a pyrimidine derivative by constructing furan ring on the parent or suitably functionalized generating ring. Moreover, there is wide range multicomponent reactions that include barbituric acids starting material for synthesis these compounds. Also, reaction with alkenes, alkynes, aldehydes, ketones, ninhydrin, and chloroacetylchloride, Cloke–Wilson rearrangement spirocyclopropyl barbiturates afforded derivatives. This review attempt to compile literature various synthetic procedures toward acids‐based spirofuro[2,3‐ ]pyrimidines.

Язык: Английский

A review of the synthetic strategies toward spirobarbiturate-fused 3- to 7-membered rings DOI
Akram Bagherinejad, Abdolali Alizadeh

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(36), С. 7188 - 7215

Опубликована: Янв. 1, 2022

This review covers the reported use of activated olefins, such as barbiturate-based for synthesis spirobarbiturate-fused three- to seven-membered carbo- and heterocyclic rings through different synthetic strategies.

Язык: Английский

Процитировано

14

Rh(II)‐Catalyzed Homocoupling/[4+1] Cycloaddition Cascade of Diazobarbiturates with Diazopyrazolones to Prepare Spirobarbiturates DOI
Kuo Wang, Yue Zhang,

Yu‐Hang Mi

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(11), С. 2596 - 2601

Опубликована: Апрель 9, 2024

Abstract Under the catalysis of Rh 2 (OAc) 4 (10 mol%) and (±)‐Me‐Pybox (20 in 1,2‐DCE at 80 °C, homocoupling/[4+1] cycloaddition cascade diazobarbiturates with diazopyrazolones proceeded readily provided spirobarbiturates 32–88% chemical yields. The structure obtained was identified by X‐ray diffraction analysis.

Язык: Английский

Процитировано

1

Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study DOI
Devanshi Magoo,

Anju Srivastava,

Shruti Gupta

и другие.

Mini-Reviews in Organic Chemistry, Год журнала: 2023, Номер 21(2), С. 246 - 270

Опубликована: Май 1, 2023

Abstract: Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold position of interest in the fields synthetic medicinal chemistry, pharmacology, material sciences physics. Spirobarbiturate which incorporate barbituric ring derivatives into spirocyclic structures emerged as attractive targets for drug discovery they are known to exhibit far-ranging pharmacological applications. In this review, we aim bring light extensive, contemporary research applied synthesis different spirobarbiturates having varied sizes (3, 5, 6 7 membered) classified manner. It presents reported methods along with their mechanistic pathways well activities some these synthesized biologically significant motifs.

Язык: Английский

Процитировано

2

Review on synthetic approaches towards barbituric acids‐based furo[2,3‐d]pyrimidines DOI
Abolfazl Olyaei, Mahdieh Sadeghpour

Journal of Heterocyclic Chemistry, Год журнала: 2023, Номер 60(11), С. 1838 - 1863

Опубликована: Июль 31, 2023

Abstract Pyrimidine annulated five‐membered heterocyclic scaffolds containing oxygen as furopyrimidine, particularly furo[2,3‐ d ]pyrimidine derivatives are an important class of compounds in pharmaceutical discovery research. Furo[2,3‐ ]pyrimidines generally synthesized either from a pyrimidine derivative by constructing furan ring on the parent or suitably functionalized generating ring. Moreover, there is wide range multicomponent reactions that include barbituric acids starting material for synthesis these compounds. Also, reaction with alkenes, alkynes, aldehydes, ketones, ninhydrin, and chloroacetylchloride, Cloke–Wilson rearrangement spirocyclopropyl barbiturates afforded derivatives. This review attempt to compile literature various synthetic procedures toward acids‐based spirofuro[2,3‐ ]pyrimidines.

Язык: Английский

Процитировано

2