A review of the synthetic strategies toward spirobarbiturate-fused 3- to 7-membered rings
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(36), С. 7188 - 7215
Опубликована: Янв. 1, 2022
This
review
covers
the
reported
use
of
activated
olefins,
such
as
barbiturate-based
for
synthesis
spirobarbiturate-fused
three-
to
seven-membered
carbo-
and
heterocyclic
rings
through
different
synthetic
strategies.
Язык: Английский
Rh(II)‐Catalyzed Homocoupling/[4+1] Cycloaddition Cascade of Diazobarbiturates with Diazopyrazolones to Prepare Spirobarbiturates
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(11), С. 2596 - 2601
Опубликована: Апрель 9, 2024
Abstract
Under
the
catalysis
of
Rh
2
(OAc)
4
(10
mol%)
and
(±)‐Me‐Pybox
(20
in
1,2‐DCE
at
80
°C,
homocoupling/[4+1]
cycloaddition
cascade
diazobarbiturates
with
diazopyrazolones
proceeded
readily
provided
spirobarbiturates
32–88%
chemical
yields.
The
structure
obtained
was
identified
by
X‐ray
diffraction
analysis.
Язык: Английский
Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study
Mini-Reviews in Organic Chemistry,
Год журнала:
2023,
Номер
21(2), С. 246 - 270
Опубликована: Май 1, 2023
Abstract:
Spiro
compounds
being
multi-cyclic
systems
linked
by
a
single
atom,
have
distinct
three
dimensionalities,
and
prominently
hold
position
of
interest
in
the
fields
synthetic
medicinal
chemistry,
pharmacology,
material
sciences
physics.
Spirobarbiturate
which
incorporate
barbituric
ring
derivatives
into
spirocyclic
structures
emerged
as
attractive
targets
for
drug
discovery
they
are
known
to
exhibit
far-ranging
pharmacological
applications.
In
this
review,
we
aim
bring
light
extensive,
contemporary
research
applied
synthesis
different
spirobarbiturates
having
varied
sizes
(3,
5,
6
7
membered)
classified
manner.
It
presents
reported
methods
along
with
their
mechanistic
pathways
well
activities
some
these
synthesized
biologically
significant
motifs.
Язык: Английский
Review on synthetic approaches towards barbituric acids‐based furo[2,3‐d]pyrimidines
Journal of Heterocyclic Chemistry,
Год журнала:
2023,
Номер
60(11), С. 1838 - 1863
Опубликована: Июль 31, 2023
Abstract
Pyrimidine
annulated
five‐membered
heterocyclic
scaffolds
containing
oxygen
as
furopyrimidine,
particularly
furo[2,3‐
d
]pyrimidine
derivatives
are
an
important
class
of
compounds
in
pharmaceutical
discovery
research.
Furo[2,3‐
]pyrimidines
generally
synthesized
either
from
a
pyrimidine
derivative
by
constructing
furan
ring
on
the
parent
or
suitably
functionalized
generating
ring.
Moreover,
there
is
wide
range
multicomponent
reactions
that
include
barbituric
acids
starting
material
for
synthesis
these
compounds.
Also,
reaction
with
alkenes,
alkynes,
aldehydes,
ketones,
ninhydrin,
and
chloroacetylchloride,
Cloke–Wilson
rearrangement
spirocyclopropyl
barbiturates
afforded
derivatives.
This
review
attempt
to
compile
literature
various
synthetic
procedures
toward
acids‐based
spirofuro[2,3‐
]pyrimidines.
Язык: Английский