Review on synthetic approaches towards barbituric acids‐based furo[2,3‐d]pyrimidines DOI
Abolfazl Olyaei, Mahdieh Sadeghpour

Journal of Heterocyclic Chemistry, Journal Year: 2023, Volume and Issue: 60(11), P. 1838 - 1863

Published: July 31, 2023

Abstract Pyrimidine annulated five‐membered heterocyclic scaffolds containing oxygen as furopyrimidine, particularly furo[2,3‐ d ]pyrimidine derivatives are an important class of compounds in pharmaceutical discovery research. Furo[2,3‐ ]pyrimidines generally synthesized either from a pyrimidine derivative by constructing furan ring on the parent or suitably functionalized generating ring. Moreover, there is wide range multicomponent reactions that include barbituric acids starting material for synthesis these compounds. Also, reaction with alkenes, alkynes, aldehydes, ketones, ninhydrin, and chloroacetylchloride, Cloke–Wilson rearrangement spirocyclopropyl barbiturates afforded derivatives. This review attempt to compile literature various synthetic procedures toward acids‐based spirofuro[2,3‐ ]pyrimidines.

Language: Английский

A review of the synthetic strategies toward spirobarbiturate-fused 3- to 7-membered rings DOI
Akram Bagherinejad, Abdolali Alizadeh

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(36), P. 7188 - 7215

Published: Jan. 1, 2022

This review covers the reported use of activated olefins, such as barbiturate-based for synthesis spirobarbiturate-fused three- to seven-membered carbo- and heterocyclic rings through different synthetic strategies.

Language: Английский

Citations

14
Rh(II)‐Catalyzed Homocoupling/[4+1] Cycloaddition Cascade of Diazobarbiturates with Diazopyrazolones to Prepare Spirobarbiturates DOI
Kuo Wang, Yue Zhang,

Yu‐Hang Mi

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(11), P. 2596 - 2601

Published: April 9, 2024

Abstract Under the catalysis of Rh 2 (OAc) 4 (10 mol%) and (±)‐Me‐Pybox (20 in 1,2‐DCE at 80 °C, homocoupling/[4+1] cycloaddition cascade diazobarbiturates with diazopyrazolones proceeded readily provided spirobarbiturates 32–88% chemical yields. The structure obtained was identified by X‐ray diffraction analysis.

Language: Английский

Citations

1
Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study DOI
Devanshi Magoo,

Anju Srivastava,

Shruti Gupta

et al.

Mini-Reviews in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(2), P. 246 - 270

Published: May 1, 2023

Abstract: Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold position of interest in the fields synthetic medicinal chemistry, pharmacology, material sciences physics. Spirobarbiturate which incorporate barbituric ring derivatives into spirocyclic structures emerged as attractive targets for drug discovery they are known to exhibit far-ranging pharmacological applications. In this review, we aim bring light extensive, contemporary research applied synthesis different spirobarbiturates having varied sizes (3, 5, 6 7 membered) classified manner. It presents reported methods along with their mechanistic pathways well activities some these synthesized biologically significant motifs.

Language: Английский

Citations

2
Review on synthetic approaches towards barbituric acids‐based furo[2,3‐d]pyrimidines DOI
Abolfazl Olyaei, Mahdieh Sadeghpour

Journal of Heterocyclic Chemistry, Journal Year: 2023, Volume and Issue: 60(11), P. 1838 - 1863

Published: July 31, 2023

Abstract Pyrimidine annulated five‐membered heterocyclic scaffolds containing oxygen as furopyrimidine, particularly furo[2,3‐ d ]pyrimidine derivatives are an important class of compounds in pharmaceutical discovery research. Furo[2,3‐ ]pyrimidines generally synthesized either from a pyrimidine derivative by constructing furan ring on the parent or suitably functionalized generating ring. Moreover, there is wide range multicomponent reactions that include barbituric acids starting material for synthesis these compounds. Also, reaction with alkenes, alkynes, aldehydes, ketones, ninhydrin, and chloroacetylchloride, Cloke–Wilson rearrangement spirocyclopropyl barbiturates afforded derivatives. This review attempt to compile literature various synthetic procedures toward acids‐based spirofuro[2,3‐ ]pyrimidines.

Language: Английский

Citations

2