Recent Advances Towards the Synthesis of Dihydrobenzofurans and Dihydroisobenzofurans

Asian Journal of Organic Chemistry, Год журнала: 2022, Номер 11(5)

Опубликована: Март 7, 2022

Abstract The 2,3‐dihydrobenzofuran heterocyclic systems are found in various biologically active natural and pharmaceutical products of biological relevance such as Phalarine, Rocaglamide, Furaquinocin A. interest the study 2,3‐dihydrobenzofurans is constantly increasing because their numerous properties anti‐tumor, anti‐cancer, anti‐tubercular, anti‐malarial activities. Different methods have been established towards synthesis involved via intra‐ inter‐molecular reactions. Besides, 1,3‐dihydroisobenzofuran structure has identified a fundamental nucleus many products, bioactive compounds, functional molecules (e. g., Pestacin, Isopestacin, Citalopram, Xylarinol B, Matriisobenzofuran, Thunberginol F7‐O‐ β ‐D‐glucopyranoside). On other hand, 1,3‐disubstituted isobenzofurans powerful structural motifs with wide range activities, like anti‐inflammatory, anti‐histaminic, anti‐HIV. In last few years, decent number diligent synthetic approaches demonstrated toward synthesizing isobenzofurans. This review focuses on effective routes developed to construct 1,3‐dihydroisobenzofurans applications recent years.

Язык: Английский

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Hydrosilylation of nitriles and tertiary amides using a zinc precursor

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(15), С. 3053 - 3058

Опубликована: Янв. 1, 2024

A competent and selective hydrosilylation of nitriles tertiary amides catalyzed by zinc bis(hexamethyldisilazide) [Zn(HMDS) 2 ] under solvent-free mild conditions are reported, as a sustainable desirable alternative to existing methods.

Язык: Английский

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Tetranuclear Zn(II) complexes with ditopic picolinohydrazone ligands: Synthesis, crystal structure, spectroscopic studies, and Hirschfeld surface analysis

Journal of Molecular Structure, Год журнала: 2022, Номер 1265, С. 133356 - 133356

Опубликована: Май 23, 2022

Язык: Английский

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Pyranoquinolone derivatives: A potent multi‐targeted pharmacological scaffold

Journal of Heterocyclic Chemistry, Год журнала: 2022, Номер 60(3), С. 369 - 391

Опубликована: Окт. 10, 2022

Abstract The search for new heterocyclic compounds with potential bioactivities continues despite the fact that extensive work has already been done on pyranoquinolones. Researchers throughout world have used pyranoquinolone nucleus extensively to generate a wide variety of bioactive heterocycles target spectrum biological targets. An in‐depth investigation into possible derivatives and their pharmacological importance is focus this overview synthetic techniques. medicinal chemists can benefit from review by developing leads are very effective fewer adverse effects than existing ones.

Язык: Английский

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An experimental investigation into the kinetics and mechanism of the aza-Michael additions of dimethyl itaconate

Tetrahedron, Год журнала: 2022, Номер 121, С. 132921 - 132921

Опубликована: Июль 14, 2022

The aza-Michael addition is a versatile reaction for the modification of α,β-unsaturated carbonyl compounds with amines. reactivity dimethyl itaconate as bio-based Michael acceptor explored in this work. Through its reactions piperidine and dibutylamine, it was found that order can be changed by choice catalyst, solvent, or concentration amine reactant. effectiveness catalysts proportional to their Lewis acidity. Competitive isomerisation into unreactive regioisomers suppressed using low-polarity solvents lower temperatures. This investigation additions has clarified possible mechanisms optimised protocol, supporting further use small molecule synthesis polymers.

Язык: Английский

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Zinc Acetate in Organic Synthesis and Catalysis: A Review

Mini-Reviews in Organic Chemistry, Год журнала: 2023, Номер 21(5), С. 555 - 587

Опубликована: Май 8, 2023

Abstract: Among the many zinc salts that can be found, acetate is one of readily available, affordable, low-hazardous Lewis acids. It referred to as a multifunctional catalyst due its unique physical and chemical properties, which show they are effective in enabling variety synthetic transformations both organic synthesis catalysis. This review included noteworthy innovations have been created during past two half decades using or reagent.

Язык: Английский

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Four new Zn(II) complexes based on 2-thienoyltrifluoroacetone and N-donor auxiliary bridging and chelating ligands: Synthesis, spectroscopic and structural studies, thermal behavior and Hirshfeld surface analysis

Polyhedron, Год журнала: 2023, Номер 242, С. 116486 - 116486

Опубликована: Июнь 10, 2023

Язык: Английский

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Tri-coordinated zinc alkyl complexes with N^S/Se coordination of imino-phosphanamidinate chalcogenide ligands as precursors for efficient hydroboration of nitriles and esters

Dalton Transactions, Год журнала: 2024, Номер 53(25), С. 10592 - 10602

Опубликована: Янв. 1, 2024

A series of tri-coordinated zinc alkyl complexes with imino-phosphanamidinate chalcogenide ligands were prepared and utilized as catalysts in the hydroboration reaction nitriles esters to obtain N , -diborylamines boronate esters.

Язык: Английский

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The Catalysts-Based Synthetic Approaches to Quinolines: A Review

Medicinal Chemistry, Год журнала: 2024, Номер 20(10), С. 921 - 937

Опубликована: Июнь 26, 2024

The most common heterocyclic aromatic molecule with potential uses in industry and medicine is quinoline. Its chemical formula C9H7N, it has a distinctive double-ring structure pyridine moiety fused benzene ring. Various synthetic approaches synthesize quinoline derivatives. These include solvent-free approach, mechanochemistry, ultrasonic, photolytic microwave catalytic approaches. One of the important catalyst-based approach which different catalysts are used such as silver-based catalysts, titanium-based nanoparticle new iridium barium-based iron-based gold-based nickel-based catalyst, some metal-based photocatalyst, α-amylase biocatalyst, by using multifunctional metal-organic framework-metal tandem catalyst etc. In present study, we summarized catalyst-promoted reactions that have been reported for synthesis Hopefully, study will be helpful researchers.

Язык: Английский

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Development of a Dual-State Emissive Naphthalimide-Based Organic Probe: Interesting Synergistic Effects from the Solid State to the Solution Phase

Crystal Growth & Design, Год журнала: 2024, Номер 24(18), С. 7632 - 7643

Опубликована: Авг. 29, 2024

Luminescent compounds have garnered significant interest for their wide range of applications in light harvesting, cell imagining, LASERs, light-emitting diodes, etc. Conventional luminescent organic molecules show emissive properties the solution phase; however, solid state, a quenching fluorescence intensity occurs. Researchers been able to overcome such challenges using phenomenon aggregation-induced emission (AIE), which enhances solid-state through close packing aided by nonbonded interactions. Such molecules, conventionally referred as AIE luminogens, are observed phase-exclusive properties, i.e., state but nonemissive phase. drawbacks prompted us investigate having both and phase, viz., dual-state [dual-state (DSE) luminogens]. Among these, naphthalimides, owing versatile conformational arrangements, prime interest. In this article, we present design, synthesis, structural characterization, detailed spectroscopic studies naphthalimide-based luminogen molecule, 6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-(6-methoxybenzothiazol-2-yl)-1H-benzoisoquinoline-1,3(2H)-dione (HPMTB). Single-crystal X-ray diffraction provided information well molecular arrangement molecule HPMTB along three dimensions. Solution-phase revealed existence mechanofluorochromic within molecule. Detailed solution-phase photophysical investigations aggregates protic polar solvent (water) via accumulation flakes. Solid-state also shows reversible mechanofluorochromism HPMTB. The current work develops materials that can attain DSE sets up foundation development use smart materials.

Язык: Английский

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