Recent Advancements in the Development of Next-Generation Dual-Targeting Antibacterial Agents

RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

DNA gyrase and topoisomerase IV are validated targets for developing dual-targeting antibacterial agents.

Язык: Английский

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Sustainable approaches towards the synthesis of functionalized imidazo[1,2-a]pyridines: Recent advancements

Journal of Molecular Structure, Год журнала: 2023, Номер 1297, С. 137012 - 137012

Опубликована: Ноя. 6, 2023

Язык: Английский

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Synthesis of Fused Imidazoles and Pyrimidinones from 2‐Aminoazines

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(3)

Опубликована: Янв. 31, 2024

Abstract Fused imidazole and pyrimidine heterocycles represent two important classes of organic compounds. Numerous synthetic methods have been developed for the synthesis these compounds due to their diverse biological activities potential pharmaceutical applications. This review provides a comprehensive assessment cutting‐edge used in fused from pyridin‐2‐amines aza derivatives involving reaction with 1,3‐dicarbonyl or α ‐halo carbonyl In addition, Groebke‐Blackburn‐Bienaymé (GBB) reaction, metal‐mediated reactions other related systems considered. We summarize pertinent literature on period 2020 2023. The analysis provided can inform future developments directed at new cost‐effective approaches analogues.

Язык: Английский

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Solvent-dependence of KI Mediated Electrosynthesis of Imidazo[1,2-a]pyridines

Chemical Research in Chinese Universities, Год журнала: 2023, Номер 39(2), С. 318 - 324

Опубликована: Фев. 18, 2023

Язык: Английский

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Copper (I) Catalysed Tandem C−C and C−N Bond Cleavage of N‐Fused Imidazoles towards the Synthesis of N‐pyridinylamides

ChemistrySelect, Год журнала: 2023, Номер 8(13)

Опубликована: Апрель 3, 2023

Abstract Copper(I) catalysed oxidative conversion of imidazopyridines into N‐pyridinylamides has been achieved via tandem C−C and C−N bond cleavages under reaction conditions. The methodology wide substrate scope products were formed in good to excellent yields. This method is suitable for the both C‐3 functionalized as well non‐functionalized

Язык: Английский

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Recent trends in the synthesis of ‘Zolimidine’: a mini-review

Chemical Papers, Год журнала: 2023, Номер 78(1), С. 93 - 109

Опубликована: Окт. 13, 2023

Язык: Английский

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Cyclization of 2-Aminopyridines as Binucleophile and Mucobromic Acid as C3 Synthon: A New Access to Imidazo[1,2-a]Pyridines

Current Chinese Science, Год журнала: 2023, Номер 3(4), С. 309 - 319

Опубликована: Май 3, 2023

Abstract: For the first time, we have developed a strategy that provides an access to imidazo[ 1,2-a] pyridines via cyclization of 2-aminopyridine with mucobromic acid as C3 synthon. In combination theoretical calculation, reaction mechanism is proposed. Background: 2-Aminopyridines are typical pyridine α-site derivatives, which received growing interest in using kind synthons organic synthesis and drug because their special binucleophilic framework. Methods: All these obtained compounds were characterized by NMR. Among them, 3a was single-crystal X-ray analysis. calculation works performed Gaussian software. Results: A series desired can be synthesized at room temperature mild procedure under promotion simple inorganic base K2CO3. Conclusion: This fits concept green chemistry, providing novel idea for construction nitrogen-containing polyheterocyclic compounds.

Язык: Английский

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Six-membered ring systems: pyridines and benzo derivatives

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 383 - 425

Опубликована: Янв. 1, 2023

Язык: Английский

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Ag(I)‐Promoted Decarboxylative Annulation of Alkynoic Acids towards 2‐Arylimidazo[1,2‐a]pyridines

ChemistrySelect, Год журнала: 2022, Номер 7(47)

Опубликована: Дек. 15, 2022

Abstract A silver‐promoted decarboxylative annulation of alkynoic acids with 2‐aminopyridines has been developed to assemble 2‐arylimidazo[1,2‐ a ]pyridines. Various functionalities in the aromatic rings two substrates are well tolerated this reaction and gave desired products good yields for broad scope substrates. Additional advantages protocol include mild conditions high regioselectivity. This report represents first example synthesis ]pyridines from acids.

Язык: Английский

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Five-membered ring systems: with more than one N atom

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 281 - 332

Опубликована: Янв. 1, 2023

Язык: Английский

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