Photocatalytic Site‐Selective Cascade Radical Addition of Biaryl Ynones for the Construction of Spiro‐ and Fused Carbon Rings

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(14), С. 1599 - 1605

Опубликована: Март 13, 2024

Comprehensive Summary Functionalized free radical addition/cyclization reactions represent an efficient way for introducing new functionality or coupling fragments to molecules. Ynones are good regional selectivity acceptors in organic synthesis, and many of bio‐relevant cyclic compounds could be easily obtained by direct cyclization reaction. Here, we report a photocatalytic cascade addition biaryl ynones, the divergent synthesis privileged carbon cycles. Additionally, further transformation multi‐functional group product into variety other derivatives demonstrates synthetic value this developed method.

Язык: Английский

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Applications of sulfonyl hydrazides in radical cyclization of alkenes

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(29), С. 5906 - 5918

Опубликована: Янв. 1, 2023

We highlighted the applications of sulfonyl hydrazides in radical cyclization alkenes, which generally has two conversion modes, including radicals and sulfoxide radicals, with an emphasis on their reaction mechanisms.

Язык: Английский

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Nickel-catalyzed regiodivergent sulfonylarylation of 1,3-enynes to access allenes and dienes

Chemical Science, Год журнала: 2024, Номер 15(33), С. 13271 - 13278

Опубликована: Янв. 1, 2024

The radical-mediated difunctionalization of 1,3-enynes facilitates rapid access to structurally diverse allenes and dienes.

Язык: Английский

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A Visible Light Photoredox Approach for Synthesizing Sulfone-Functionalized Cyclopropenes

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

We have developed a tandem method essential for synthesizing sulfone-containing organic molecules, which has wide-ranging applications in agrochemicals, medicinal chemistry, and polymer science. This involves two-step process: an iodo-sulfonylated intermediate is formed initially, followed by elimination to regenerate the double bond, ultimately yielding cyclopropenes. Control studies confirmed intermediacy of cyclopropane within reaction sequence. Additionally, this protocol demonstrated excellent tolerance various functional groups. Moreover, resulting sulfonylated-cyclopropenes are promising synthons late-stage modification molecular diversification.

Язык: Английский

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Radical Carbocyclization Intercepted Reductive C‐C Bond Formation Between 1,n‐Enynes or Dienes and Electron‐Poor Olefins/Alkynes

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(22), С. 4688 - 4693

Опубликована: Авг. 20, 2024

Abstract Metal hydride catalyzed hydrogen atom transfer (MHAT) reaction of 1,6‐enyne and electron‐poor alkene progresses through a radical cascade, involving ene‐yne cyclization exocyclic C−C bond formation superseding the direct reductive olefin cross‐coupling; which is realized in current study. The generality this manifold demonstrated with range functionalized dienes structurally distinct olefins alkynes as partners. Current work unveils merger MHAT‐based olefin‐hydro functionalization ene‐one cyclization.

Язык: Английский

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Paired Electrocatalysis-Enabled Cross Coupling of Sulfinamides with Olefins toward the Synthesis of Vinyl Sulfoximines

Organic Letters, Год журнала: 2024, Номер 26(40), С. 8463 - 8467

Опубликована: Окт. 2, 2024

We present here a novel paired electrocatalysis-enabled convenient synthesis of the (

Язык: Английский

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Visible-light-induced hydrosulfonylation of alkynes driven by electron-donor–acceptor (EDA) complexes

Tetrahedron Letters, Год журнала: 2024, Номер 153, С. 155368 - 155368

Опубликована: Ноя. 16, 2024

Язык: Английский

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