Atom-Efficient Chlorinative Dearomatization of Naphthol, Quinolinol, and Isoquinolinol Derivatives using Trichloroisocyanuric Acid (TCCA) DOI

Jenna D. Caudle,

Mary Ennis,

Dillon C. Dodge

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

A variety of dearomatized compounds have been prepared in moderate to excellent yields from planar scaffolds using trichloroisocyanuric acid (TCCA) as an atom-economical chlorinating agent. The method tolerates a broad range functionalities and can take place several green and/or sustainable solvents. Twenty-one examples 1,1-dichlorinated products 2-naphthols analogous heteroarenes (quinolinols, isoquinolinols, quinazolinol) are reported along with five monochlorinated products. utility the 1,1-dichloronaphthalenone product reactive intermediate species is demonstrated two-step, one-pot reaction carried out solvent. In mechanistic investigation, coordination agent hydroxy substituent scaffold prior chlorine transfer implicated.

Язык: Английский

Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination DOI

Anh Thu Nguyen,

Houng Kang, Truong Giang Luu

и другие.

Bulletin of the Korean Chemical Society, Год журнала: 2024, Номер 45(9), С. 738 - 758

Опубликована: Сен. 1, 2024

Abstract Halogenation is one of the most important transformations in organic synthesis. Halogenated compounds are employed many reactions to prepare useful molecules. Many methods have been developed introduce halogens into different compounds. Visible light‐mediated efficient, low‐toxic, and mild‐condition applied for various chemistry transformations. Remarkably, there has an increasing development application visible light‐induced halogenation recent years. Herein, we present a comprehensive summary including chlorination, bromination, iodination under light irradiation since 2020.

Язык: Английский

Процитировано

5

Visible light-induced perfluoroalkylation reaction of indoles in the presence of Na2-eosin Y DOI
Xiaoxiao He, Du Chen, Zhenjiang Liu

и другие.

Tetrahedron Letters, Год журнала: 2025, Номер 162, С. 155571 - 155571

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0

Five-membered ring systems: With more than 1 N atom DOI
Larry Yet

Progress in heterocyclic chemistry, Год журнала: 2024, Номер unknown, С. 211 - 257

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0

Comprehensive and in-depth insights into photo-assisted halogenation reactions: a pharmaceutical industry perspective DOI
Anoop Prabhu,

P. Mali,

Satyapaul A. Singh

и другие.

Reviews in Chemical Engineering, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Abstract Halogenation reactions are a vital area of study for the pharmaceutical industry. The reaction conditions along with reactors and their scale-up is thrust in drug synthesis manufacturing. There shift research community towards accommodating renewable energy sources which has driven scientists to include that sustainable aid making overall process efficient. This review provides comprehensive overview challenges selecting best catalyst, light source fluorination, chlorination bromination reactions. paper goes step further explain photoreactors’ design modelling as well same. Overall, it view diverse scientific areas, from halogenation potential photochemical batch flow approaches

Язык: Английский

Процитировано

0

Atom-Efficient Chlorinative Dearomatization of Naphthol, Quinolinol, and Isoquinolinol Derivatives using Trichloroisocyanuric Acid (TCCA) DOI

Jenna D. Caudle,

Mary Ennis,

Dillon C. Dodge

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

A variety of dearomatized compounds have been prepared in moderate to excellent yields from planar scaffolds using trichloroisocyanuric acid (TCCA) as an atom-economical chlorinating agent. The method tolerates a broad range functionalities and can take place several green and/or sustainable solvents. Twenty-one examples 1,1-dichlorinated products 2-naphthols analogous heteroarenes (quinolinols, isoquinolinols, quinazolinol) are reported along with five monochlorinated products. utility the 1,1-dichloronaphthalenone product reactive intermediate species is demonstrated two-step, one-pot reaction carried out solvent. In mechanistic investigation, coordination agent hydroxy substituent scaffold prior chlorine transfer implicated.

Язык: Английский

Процитировано

0