Recent advances in the synthesis of trifluoromethyl-containing heterocyclic compounds via trifluoromethyl building blocks
Yaopeng Liu,
Qingyu Tian,
Jin Ge
и другие.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(31), С. 6246 - 6276
Опубликована: Янв. 1, 2024
Recent
advances
in
the
preparation
of
trifluoromethyl-containing
heterocyclics
via
trifluoromethyl
building
block
strategies
over
period
from
2019
to
present
are
systematically
summarized
and
discussed.
Язык: Английский
[3 + 2] Cycloaddition Reaction of Vinylsulfonium Salts with Hydrazonoyl Halides: Synthesis of Pyrazoles
Wen-Jing Luo,
Xiuwen Liang,
Maizhuo Chen
и другие.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(14), С. 10066 - 10076
Опубликована: Июль 2, 2024
An
efficient
[3
+
2]
cycloaddition
reaction
between
in
situ
generated
nitrile
imines
from
hydrazonoyl
halides
and
vinylsulfonium
salts
is
developed.
The
are
demonstrated
to
be
a
new
class
of
partner
for
conduct
the
reaction.
process
provides
concise
method
construction
pyrazole
derivatives
under
mild
conditions
with
broad
substrate
scope,
good
product
yields,
high
regioselectivity.
Язык: Английский
Visible-Light-Induced Trifluoromethyl Radical Addition to Thiocarbonyl of Thioamide Derivatives
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
An
effective
trifluoromethyl
radical
addition
to
the
thiocarbonyl
of
thioamide
derivatives
is
described,
which
produces
various
trifluoromethylthiolated
N-heterocycles
such
as
6-(trifluoromethylthio)phenanthridine,
2-(trifluoromethylthio)indole,
and
2-(trifluoromethylthio)benzothiazole
under
visible-light
irradiation.
The
process
features
advantages
mild
reaction
conditions,
a
cheap
easily
available
source
(CF3Br),
green
energy,
well
broad
substrate
scope.
mechanism
investigated
in
detail,
scale-up
experiments
are
performed.
Язык: Английский