Regio- and Stereoselective [3 + 2] cycloaddition of Isatogens with functionalized alkenes and its application to the synthesis of Halichrome a
Tetrahedron Letters,
Год журнала:
2025,
Номер
unknown, С. 155626 - 155626
Опубликована: Апрель 1, 2025
Язык: Английский
Boron Compounds as Key Drivers of Innovation: Exploring Their Role in Environmental Remediation, Sustainable Agriculture, Advanced Biomedical Applications, and Green Chemistry
Journal of Organometallic Chemistry,
Год журнала:
2025,
Номер
1035, С. 123688 - 123688
Опубликована: Апрель 28, 2025
Язык: Английский
Isatogenols as Precursors for the Synthesis of Fully Substituted Indolines through Regio- and Stereoselective [3 + 2] Cycloaddition Using Various Olefins
Organic Letters,
Год журнала:
2024,
Номер
26(15), С. 2908 - 2912
Опубликована: Апрель 1, 2024
Here,
we
describe
a
unique
reactivity
of
isatogen
derivatives
bearing
hydroxy
group
at
the
C3-position
(isatogenol)
and
their
synthetic
application
to
highly
regio-
stereoselective
[3
+
2]
cycloaddition
reactions.
This
method
provides
facile
access
polyfused
functionalized
heterocycles
including
consecutive
stereocenters.
Furthermore,
DFT
calculations
revealed
that
hydrogen
bonding
is
key
controlling
stereoselectivity
in
using
acrylates.
Язык: Английский