Redox Biology,
Год журнала:
2023,
Номер
64, С. 102797 - 102797
Опубликована: Июнь 25, 2023
Mitochondria
are
highly
dynamic
organelles
essential
for
cell
metabolism,
growth,
and
function.
It
is
becoming
increasingly
clear
that
endothelial
dysfunction
significantly
contributes
to
the
pathogenesis
vascular
remodeling
of
various
lung
diseases,
including
pulmonary
arterial
hypertension
(PAH),
mitochondria
at
center
this
dysfunction.
The
more
we
uncover
role
play
in
disease,
apparent
it
becomes
multiple
pathways
involved.
To
achieve
effective
treatments,
must
understand
how
these
dysregulated
be
able
intervene
therapeutically.
We
know
nitric
oxide
signaling,
glucose
fatty
acid
oxidation,
TCA
cycle
abnormal
PAH,
along
with
alterations
mitochondrial
membrane
potential,
proliferation,
apoptosis.
However,
incompletely
characterized
especially
cells,
highlighting
urgent
need
further
research.
This
review
summarizes
what
currently
known
about
metabolism
facilitates
a
metabolic
shift
cells
induces
during
PAH.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Янв. 3, 2020
Abstract
Mitochondria
are
signaling
organelles
that
regulate
a
wide
variety
of
cellular
functions
and
can
dictate
cell
fate.
Multiple
mechanisms
contribute
to
communicate
mitochondrial
fitness
the
rest
cell.
Recent
evidence
confers
new
role
for
TCA
cycle
intermediates,
generally
thought
be
important
biosynthetic
purposes,
as
molecules
with
controlling
chromatin
modifications,
DNA
methylation,
hypoxic
response,
immunity.
This
review
summarizes
by
which
abundance
different
metabolites
controls
function
fate
in
contexts.
We
will
focus
on
how
these
mediated
affect
physiology
disease.
Journal of the American College of Cardiology,
Год журнала:
2019,
Номер
73(2), С. 190 - 209
Опубликована: Янв. 1, 2019
Endothelial
to
mesenchymal
transition
(EndMT)
is
a
process
whereby
an
endothelial
cell
undergoes
series
of
molecular
events
that
lead
change
in
phenotype
toward
(e.g.,
myofibroblast,
smooth
muscle
cell).
EndMT
plays
fundamental
role
during
development,
and
mounting
evidence
indicates
involved
adult
cardiovascular
diseases
(CVDs),
including
atherosclerosis,
pulmonary
hypertension,
valvular
disease,
fibroelastosis.
Therefore,
the
targeting
may
hold
therapeutic
promise
for
treating
CVD.
However,
field
faces
number
challenges,
lack
precise
functional
definition,
understanding
causative
pathological
CVDs
(versus
being
“bystander-phenomenon”),
robust
human
data
corroborating
extent
causality
CVDs.
Here,
we
review
this
emerging
but
exciting
field,
propose
framework
its
systematic
advancement
at
translational
levels.
Frontiers in Cell and Developmental Biology,
Год журнала:
2021,
Номер
8
Опубликована: Янв. 12, 2021
Metabolic
reprogramming
has
been
widely
recognized
as
a
hallmark
of
malignancy.
The
uptake
and
metabolism
amino
acids
are
aberrantly
upregulated
in
many
cancers
that
display
addiction
to
particular
acids.
Amino
facilitate
the
survival
proliferation
cancer
cells
under
genotoxic,
oxidative,
nutritional
stress.
Thus,
targeting
acid
is
becoming
potential
therapeutic
strategy
for
patients.
In
this
review,
we
will
systematically
summarize
recent
progress
malignancy
discuss
their
interconnection
with
mammalian
target
rapamycin
complex
1
(mTORC1)
signaling,
epigenetic
modification,
tumor
growth
immunity,
ferroptosis.
Finally,
highlight
applications.
Cancer Discovery,
Год журнала:
2019,
Номер
9(3), С. 416 - 435
Опубликована: Янв. 9, 2019
Pancreatic
ductal
adenocarcinoma
(PDA)
has
a
poor
prognosis,
and
new
strategies
for
prevention
treatment
are
urgently
needed.
We
previously
reported
that
histone
H4
acetylation
is
elevated
in
pancreatic
acinar
cells
harboring
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11338 - 11338
Опубликована: Окт. 20, 2021
Mitochondria
are
the
energy
center
of
cell.
They
found
in
cell
cytoplasm
as
dynamic
networks
where
they
adapt
production
based
on
cell’s
needs.
also
at
proinflammatory
response
and
have
essential
roles
against
pathogenic
infections.
a
major
site
for
Reactive
Oxygen
Species
(ROS;
or
free
radicals),
which
to
fight
infection.
However,
excessive
uncontrolled
can
become
deleterious
cell,
leading
mitochondrial
tissue
damage.
Pathogens
exploit
role
mitochondria
during
infection
by
affecting
oxidative
phosphorylation
mechanism
(OXPHOS),
network
disrupting
communication
between
nucleus
mitochondria.
The
these
biological
processes
makes
organelle
good
targets
development
therapeutic
strategies.
In
this
review,
we
presented
summary
endosymbiotic
origin
their
involvement
pathogen
response,
well
potential
promising
infectious
diseases
chronic
inflammatory
diseases.
