Mitochondrial TCA cycle metabolites control physiology and disease

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Янв. 3, 2020

Abstract Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness the rest cell. Recent evidence confers new role for TCA cycle intermediates, generally thought be important biosynthetic purposes, as molecules with controlling chromatin modifications, DNA methylation, hypoxic response, immunity. This review summarizes by which abundance different metabolites controls function fate in contexts. We will focus on how these mediated affect physiology disease.

Язык: Английский

---

Functions and mechanisms of non-histone protein acetylation

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 20(3), С. 156 - 174

Опубликована: Ноя. 22, 2018

Язык: Английский

---

Endothelial to Mesenchymal Transition in Cardiovascular Disease

Journal of the American College of Cardiology, Год журнала: 2019, Номер 73(2), С. 190 - 209

Опубликована: Янв. 1, 2019

Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes series of molecular events that lead change in phenotype toward (e.g., myofibroblast, smooth muscle cell). EndMT plays fundamental role during development, and mounting evidence indicates involved adult cardiovascular diseases (CVDs), including atherosclerosis, pulmonary hypertension, valvular disease, fibroelastosis. Therefore, the targeting may hold therapeutic promise for treating CVD. However, field faces number challenges, lack precise functional definition, understanding causative pathological CVDs (versus being “bystander-phenomenon”), robust human data corroborating extent causality CVDs. Here, we review this emerging but exciting field, propose framework its systematic advancement at translational levels.

Язык: Английский

---

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 19(9), С. 563 - 578

Опубликована: Июнь 21, 2018

Язык: Английский

---

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Cancer Cell, Год журнала: 2020, Номер 37(2), С. 147 - 156

Опубликована: Фев. 1, 2020

Язык: Английский

---

Metabolism of Amino Acids in Cancer

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 8

Опубликована: Янв. 12, 2021

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism amino acids are aberrantly upregulated in many cancers that display addiction to particular acids. Amino facilitate the survival proliferation cancer cells under genotoxic, oxidative, nutritional stress. Thus, targeting acid is becoming potential therapeutic strategy for patients. In this review, we will systematically summarize recent progress malignancy discuss their interconnection with mammalian target rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth immunity, ferroptosis. Finally, highlight applications.

Язык: Английский

---

Metabolic signatures of cancer cells and stem cells

Nature Metabolism, Год журнала: 2019, Номер 1(2), С. 177 - 188

Опубликована: Фев. 11, 2019

Язык: Английский

---

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Cancer Discovery, Год журнала: 2019, Номер 9(3), С. 416 - 435

Опубликована: Янв. 9, 2019

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring

Язык: Английский

---

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Cell Metabolism, Год журнала: 2019, Номер 30(1), С. 92 - 110.e4

Опубликована: Апрель 18, 2019

Язык: Английский

---

Mitochondria as a Cellular Hub in Infection and Inflammation

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11338 - 11338

Опубликована: Окт. 20, 2021

Mitochondria are the energy center of cell. They found in cell cytoplasm as dynamic networks where they adapt production based on cell’s needs. also at proinflammatory response and have essential roles against pathogenic infections. a major site for Reactive Oxygen Species (ROS; or free radicals), which to fight infection. However, excessive uncontrolled can become deleterious cell, leading mitochondrial tissue damage. Pathogens exploit role mitochondria during infection by affecting oxidative phosphorylation mechanism (OXPHOS), network disrupting communication between nucleus mitochondria. The these biological processes makes organelle good targets development therapeutic strategies. In this review, we presented summary endosymbiotic origin their involvement pathogen response, well potential promising infectious diseases chronic inflammatory diseases.

Язык: Английский

---