Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors DOI
Linhui Zhai, Xinglong Jia,

Yu-Lu Chen

и другие.

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Язык: Английский

Mitochondrial protein import stress DOI
Nikolaus Pfanner, Fabian den Brave, Thomas Becker

и другие.

Nature Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

3
Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer DOI
Wen-Yu Lyu,

Jun Cao,

Wei-Qing Deng

и другие.

Phytomedicine, Год журнала: 2025, Номер 141, С. 156647 - 156647

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

0
UBE4B modulates BET inhibitor sensitivity via KLHL22-JAK2-PIM1 axis in hepatocellular carcinoma DOI

Li Wang,

Xia‐Juan Huan,

Shanshan Song

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116943 - 116943

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
How to exploit the recycling system of a cell DOI Creative Commons
Sasha L. Evans, Bethany A. Haynes,

Delia Capatina

и другие.

eLife, Год журнала: 2025, Номер 14

Опубликована: Фев. 21, 2025

Nature has inspired the design of improved inhibitors for cancer-causing proteins.

Язык: Английский

Процитировано

0
Unclogging of the TOM complex under import stress DOI Creative Commons
Joshua Jackson, Thomas Becker

Biological Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Mitochondrial functions and biogenesis depend on the import of more than 1,000 proteins which are synthesized as precursor cytosolic ribosomes. protein translocases sort into mitochondrial sub-compartments: outer inner membrane, intermembrane space matrix. The translocase membrane (TOM complex) constitutes major site for most these proteins. Defective translocases, premature folding precursor, or depletion potential can cause clogging TOM channel by a protein. This impairs further leads to accumulation in cell that perturbates homeostasis, leading proteotoxic stress cell. Therefore, unclogging translocon is critical maintaining cellular function. Ubiquitylation AAA-ATPases play central role extraction deliver them proteasome degradation. Here we summarize our understanding molecular mechanisms remove such translocation-stalled from translocation regenerate complex import.

Язык: Английский

Процитировано

0
Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in C. elegans models of Alzheimer’s disease DOI Creative Commons
Lihua Sun,

Jiahui Liu,

Mingxia Lu

и другие.

Journal of Biological Chemistry, Год журнала: 2025, Номер unknown, С. 110226 - 110226

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors DOI
Linhui Zhai, Xinglong Jia,

Yu-Lu Chen

и другие.

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Язык: Английский

Процитировано

1