Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors DOI
Linhui Zhai, Xinglong Jia,

Yu-Lu Chen

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Mitochondrial protein import stress DOI
Nikolaus Pfanner, Fabian den Brave, Thomas Becker

et al.

Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

3
Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer DOI
Wen-Yu Lyu,

Jun Cao,

Wei-Qing Deng

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 141, P. 156647 - 156647

Published: March 15, 2025

Language: Английский

Citations

0
UBE4B modulates BET inhibitor sensitivity via KLHL22-JAK2-PIM1 axis in hepatocellular carcinoma DOI

Li Wang,

Xia‐Juan Huan,

Shanshan Song

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116943 - 116943

Published: April 1, 2025

Language: Английский

Citations

0
How to exploit the recycling system of a cell DOI Creative Commons
Sasha L. Evans, Bethany A. Haynes,

Delia Capatina

et al.

eLife, Journal Year: 2025, Volume and Issue: 14

Published: Feb. 21, 2025

Nature has inspired the design of improved inhibitors for cancer-causing proteins.

Language: Английский

Citations

0
Unclogging of the TOM complex under import stress DOI Creative Commons
Joshua Jackson, Thomas Becker

Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Abstract Mitochondrial functions and biogenesis depend on the import of more than 1,000 proteins which are synthesized as precursor cytosolic ribosomes. protein translocases sort into mitochondrial sub-compartments: outer inner membrane, intermembrane space matrix. The translocase membrane (TOM complex) constitutes major site for most these proteins. Defective translocases, premature folding precursor, or depletion potential can cause clogging TOM channel by a protein. This impairs further leads to accumulation in cell that perturbates homeostasis, leading proteotoxic stress cell. Therefore, unclogging translocon is critical maintaining cellular function. Ubiquitylation AAA-ATPases play central role extraction deliver them proteasome degradation. Here we summarize our understanding molecular mechanisms remove such translocation-stalled from translocation regenerate complex import.

Language: Английский

Citations

0
Inactivation of SIAH-1 E3 ligase attenuates Aβ toxicity by suppressing ubiquitin-dependent DVE-1 degradation in C. elegans models of Alzheimer’s disease DOI Creative Commons
Lihua Sun,

Jiahui Liu,

Mingxia Lu

et al.

Journal of Biological Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 110226 - 110226

Published: May 1, 2025

Language: Английский

Citations

0
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors DOI
Linhui Zhai, Xinglong Jia,

Yu-Lu Chen

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Language: Английский

Citations

1