The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

International Journal of Molecular Sciences, Год журнала: 2017, Номер 18(1), С. 120 - 120

Опубликована: Янв. 10, 2017

Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in potentials the generation reactive oxygen species (ROS). amount ROS produced by correlates with particle size, shape, surface area, chemistry. multiple functions cellular biology, a key factor NP-induced toxicity, as well modulation signaling involved cell death, proliferation, differentiation. In this review, we briefly explained NP classes their biomedical applications describe sources roles NP-related vitro vivo. Furthermore, also described metal stem biology. Although requires further investigation, characterization production are promising application areas regenerative medicine medical devices.

Язык: Английский

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Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer

International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(7), С. 1979 - 1979

Опубликована: Июль 6, 2018

The application of nanotechnology for the treatment cancer is mostly based on early tumor detection and diagnosis by nanodevices capable selective targeting delivery chemotherapeutic drugs to specific site. Due remarkable properties gold nanoparticles, they have long been considered as a potential tool various cancers drug applications. These include high surface area volume ratio, plasmon resonance, chemistry multi-functionalization, facile synthesis, stable nature. Moreover, non-toxic non-immunogenic nature nanoparticles permeability retention effect provide additional benefits enabling easy penetration accumulation at sites. Various innovative approaches with are under development. In this review, we an overview recent progress made in detection, delivery, imaging, photothermal photodynamic therapy their current limitations terms bioavailability fate nanoparticles.

Язык: Английский

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The current application of nanotechnology in food and agriculture

Journal of Food and Drug Analysis, Год журнала: 2018, Номер 27(1), С. 1 - 21

Опубликована: Дек. 24, 2018

The rapid development of nanotechnology has been facilitating the transformations traditional food and agriculture sectors, particularly invention smart active packaging, nanosensors, nanopesticides nanofertilizers. Numerous novel nanomaterials have developed for improving quality safety, crop growth, monitoring environmental conditions. In this review most recent trends in are discussed challenging tasks promising opportunities sectors from selected studies addressed. toxicological fundamentals risk assessment these new products also discussed. We highlighted potential application bio-synthesized bio-inspired nanomaterial sustainable development. However, fundamental questions with regard to high performance, low toxic need be addressed fuel nanotechnology. Regulation legislation paramount regulating manufacturing, processing, application, as well disposal nanomaterials. Efforts still needed strengthen public awareness acceptance nano-enabled products. conclude that offers a plethora opportunities, by providing alternative sectors.

Язык: Английский

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Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity

Journal of King Saud University - Science, Год журнала: 2016, Номер 30(2), С. 168 - 175

Опубликована: Окт. 15, 2016

Biological reduction agents are being explored worldwide to minimize the effects of toxic chemicals used in nanoparticle fabrication. The present study states a green approach for synthesis zinc oxide nanoparticles employing aqueous flower extract Nyctanthes arbor-tristis. Flower was as biological agent synthesizing from acetate dihydrate. Synthesis conditions were optimized maximal and narrow size range nanoparticles. resultant nanopowder characterized using various analytical techniques, such UV–Visible spectroscopy, Fourier Transform Infrared X-ray diffraction, Dynamic Light Scattering Transmission Electron Microscopy. stored dried form found be stable after 4 months. obtained upon at optimum 12–32 nm reported by TEM. diffraction studies confirmed crystalline nature indicating particle within provided electron microscopy data. Nanoparticles tested their antifungal potential active against all five phytopathogens with lowest MIC value recorded 16 μg/mL. Hence, an easy effective nanoparticles, efficient is this study.

Язык: Английский

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A review on the biosynthesis of metal and metal salt nanoparticles by microbes

RSC Advances, Год журнала: 2019, Номер 9(23), С. 12944 - 12967

Опубликована: Янв. 1, 2019

This review paper is a comprehensive outline of biosynthesis metal nanoparticles by microbes including their mechanistic aspects, large-scale production approaches, mechanism action, advantages and limitations bio-mediated approach.

Язык: Английский

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Nanopriming technology for enhancing germination and starch metabolism of aged rice seeds using phytosynthesized silver nanoparticles

Scientific Reports, Год журнала: 2017, Номер 7(1)

Опубликована: Авг. 9, 2017

Application of nanomaterials for agriculture is relatively new as compared to their use in biomedical and industrial sectors. In order promote sustainable nanoagriculture, biocompatible silver nanoparticles (AgNPs) have been synthesized through green route using kaffir lime leaf extract nanopriming agent enhancing seed germination rice aged seeds. Results various characterization techniques showed the successful formation AgNPs which were capped with phytochemicals present plant extract. Rice seeds primed phytosynthesized at 5 10 ppm significantly improved performance seedling vigor unprimed control, AgNO3 priming, conventional hydropriming. Nanopriming could enhance α-amylase activity, resulting higher soluble sugar content supporting seedlings growth. Furthermore, stimulated up-regulation aquaporin genes germinating Meanwhile, more ROS production was observed treatment control other priming treatments, suggesting that both aquaporins play important roles germination. Different mechanisms underlying nanopriming-induced proposed, including creation nanopores enhanced water uptake, rebooting ROS/antioxidant systems seeds, generation hydroxyl radicals cell wall loosening, nanocatalyst fastening starch hydrolysis.

Язык: Английский

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Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems

Emergent Materials, Год журнала: 2022, Номер 5(6), С. 1593 - 1615

Опубликована: Янв. 4, 2022

Язык: Английский

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Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Год журнала: 2019, Номер 10(1)

Опубликована: Июль 8, 2019

In recent years, zinc oxide nanoparticles (ZnO NPs) have gained tremendous attention attributed to their unique properties. Notably, evidence has shown that is an important nutrient in living organisms. As such, both prokaryotes and eukaryotes including bacteria, fungi yeast are exploited for the synthesis of ZnO NPs by using microbial cells or enzyme, protein other biomolecules compounds either intracellular extracellular route. exhibit antimicrobial properties, however, properties (NPs) depended upon on size shape, which make them specific various applications. Nevertheless, desired shape can be obtained through optimization process microbes mediated manipulating reaction conditions. It should noted synthesized chemical physical methods. Nonetheless, these methods expensive not environmentally friendly. On account, rapidly evolved recently where cleaner, eco-friendly, non-toxic biocompatible as alternatives practices. Moreover, form more effective than bulk counterparts thus, they been explored many potential applications animals industry. with advent multi-drug resistant strains, emerged agents. This mainly due superior combating a broad spectrum pathogens. known essential trace element most biological function animal's body. reported significantly enhance health production farm animals. Thus, this paper reviews microbes, mechanisms synthesis, parameters application agent feed supplement animal industry well toxicological hazards

Язык: Английский

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Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review

Biotechnology Reports, Год журнала: 2020, Номер 25, С. e00427 - e00427

Опубликована: Янв. 31, 2020

Due to development of bacterial resistance the conventional antibiotics, treatment infections has become a major issue concern. The unprescribed and uncontrolled use antibiotics lead rapid antibiotic in strains. Therefore, novel potent bactericidal agents is great clinical importance. Interestingly, metallic nanoparticles (NPs) have been proven be promising alternative antibiotics. NPs interact with important cellular organelles biomolecules like DNA, enzymes, ribosomes, lysosomes that can affect cell membrane permeability, oxidative stress, gene expression, protein activation, enzyme activation. Since, target multiple concurrently; it becomes very difficult for bacteria develop against them. Currently, there are different physical chemical methods utilized synthesis. However, most these processes costly potentially hazardous living organisms environment. need an eco-friendly cost-effective method Recently, ‘green synthesis’ approaches gaining lot attention. It demonstrated bacteria, yeast, fungi, plant cells reduce inorganic metal ions into by their metabolites. Both yield stability biogenic quite satisfactory. In current article, we addressed green synthesis various reported till date highlighted modes mechanisms antibacterial properties. highly anticipated could viable economical alternatives treating drug resistant near future.

Язык: Английский

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Surface Modifications of Nanoparticles for Stability in Biological Fluids

Materials, Год журнала: 2018, Номер 11(7), С. 1154 - 1154

Опубликована: Июль 6, 2018

Due to the high surface: volume ratio and extraordinary properties arising from nanoscale (optical, electric, magnetic, etc.), nanoparticles (NPs) are excellent candidates for multiple applications. In this context, nanoscience is opening a wide range of modern technologies in biological biomedical fields, among others. However, one main drawbacks that still delays its fast evolution effectiveness related behavior nanomaterials presence fluids. Unfortunately, fluids characterized by ionic strengths which usually induce NP aggregation. Besides problem, content biomacromolecules—such as lipids, sugars, nucleic acids and, especially, proteins—also affects stability viability some applications due to, example, formation protein corona around NPs. Here, we will review most common strategies achieve stable NPs dispersions strength also, antifouling avoid adsorption.

Язык: Английский

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