Promising cellulose–based functional gels for advanced biomedical applications: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 260, С. 129600 - 129600

Опубликована: Янв. 23, 2024

Язык: Английский

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Electrospun silk fibroin/fibrin vascular scaffold with superior mechanical properties and biocompatibility for applications in tissue engineering

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 16, 2024

Abstract Electrospun scaffolds play important roles in the fields of regenerative medicine and vascular tissue engineering. The aim research described here was to develop a scaffold that mimics structural functional properties natural scaffolding. mechanical artificial represent key issue for successful transplantation small diameter engineering blood vessels. We blended silk fibroin (SF) fibrin fabricate composite using electrospinning overcome shortcomings with respect its properties. Subsequently, we then carefully investigated morphological, properties, hydrophilicity, hemocompatibility, degradation, cytocompatibility biocompatibility SF/fibrin (0:100), (15:85), (25:75), (35:65) scaffolds. Based on these vitro results, implanted (25:75) subcutaneously analyzed vivo degradation histocompatibility. fiber structure hybrid smooth uniform, diameters were relatively small. Compared scaffold, clearly displayed increased strength, but hydrophilicity weakened correspondingly. All showed excellent compatibility appropriate biodegradation rates. proliferation adhesion MSCs. results animal experiments confirmed faster than SF effectively promoted regeneration cell infiltration. all, electrospun balanced controllable biomechanical degradability, good compatibility. Thus, this proved be an ideal candidate material

Язык: Английский

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Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering

Bioactive Materials, Год журнала: 2022, Номер 19, С. 511 - 537

Опубликована: Май 7, 2022

Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few polymer used biomedicine because of facile synthesis, controllable structure, biocompatibility, biomimetic viscoelastic mechanical behavior, and functional groups available for modification. In recent years, various multifunctional designs biomedical applications, including cardiovascular, orthopedic, muscle tissue, skin nerve spinal cord, bioimaging, drug or gene delivery based on citrate-based polymers, have been extensively studied, many them good clinical application potential. this review, we summarize progress design polymers. We also discuss further development tailored properties meet requirements applications.

Язык: Английский

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Polycaprolactone Composites/Blends and Their Applications Especially in Water Treatment

ChemEngineering, Год журнала: 2023, Номер 7(6), С. 104 - 104

Опубликована: Ноя. 2, 2023

Biodegradable poly(ɛ-caprolactone) (PCL) and its composites or blends have received a lot of attention in the last decade because their potential applications human life environmental remediation. Greater efforts been made to develop biodegradable chemical materials as adsorbents that do not pollute environment order replace traditional materials. Among numerous types degradable materials, PCL is currently most promising, popular, best material be developed, it referred “green” eco-friendly material. Membranes for water treatment, packaging compost bags, controlled drug carriers, biomaterials tissues such bone, cartilage, ligament, skeletal muscle, skin, cardiovascular nerve are just some this polymer (PCL). The goal review present brief overview PCL, syntheses properties, composites, provide detailed investigation into utility PCL/PCL-based adsorbing agents removal dyes/heavy metal ions. Overall, can confirmed were found significant competitors other well-known treatment wastewaters, necessitating thorough manufacture.

Язык: Английский

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Application of decellularized vascular matrix in small-diameter vascular grafts

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 10

Опубликована: Янв. 6, 2023

Coronary artery bypass grafting (CABG) remains the most common procedure used in cardiovascular surgery for treatment of severe coronary atherosclerotic heart disease. In grafting, small-diameter vascular grafts can potentially replace vessels patient. The complete retention extracellular matrix, superior biocompatibility, and non-immunogenicity decellularized matrix are unique advantages tissue-engineered grafts. However, after implantation, is also subject to thrombosis neoplastic endothelial hyperplasia, two major problems that hinder its clinical application. keys improving long-term patency as include facilitating early endothelialization avoiding intravascular thrombosis. This review article sequentially introduces six aspects follows: design criteria grafts, components changing sources shortcomings decellularization technologies, modification methods commercialization progress well application prospects

Язык: Английский

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Biofabrication with microbial cellulose: from bioadaptive designs to living materials

Chemical Society Reviews, Год журнала: 2024, Номер 53(14), С. 7363 - 7391

Опубликована: Янв. 1, 2024

Nanocellulose is not only a renewable material but also brings functions that are opening new technological opportunities. Here we discuss special subset of this material, in its fibrillated form, which produced by aerobic microorganisms, namely, bacterial nanocellulose (BNC). BNC offers distinct advantages over plant-derived counterparts, including high purity and degree polymerization as well crystallinity, strength, water-holding capacity, among others. More remarkably, beyond classical fermentative protocols, it possible to grow on non-planar interfaces, possibilities the assembly advanced bottom-up structures. In review, recent advances area BNC-based biofabrication three-dimensional (3D) designs following solid- soft-material templating. These methods shown suitable platforms achieve bioadaptive constructs comprising highly interlocked biofilms can be tailored with precise control nanoscale morphological features. opens applications using traditional manufacturing routes, direct ink writing hydrogels. This review emphasizes critical contributions microbiology, colloid surface science, additive achieving from living matter. The future impact expected take advantage energy integration, residue utilization, circularity social latitudes. Leveraging existing infrastructure, scaleup routes will contribute generation materials rooted exciting synergies combine biology, chemistry, engineering sciences.

Язык: Английский

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A review of sodium alginate-based hydrogels: Structure, mechanisms, applications, and perspectives

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139151 - 139151

Опубликована: Дек. 1, 2024

Язык: Английский

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History, progress and future challenges of artificial blood vessels: a narrative review.

PubMed, Год журнала: 2022, Номер 3(1), С. 81 - 98

Опубликована: Янв. 1, 2022

Cardiovascular disease serves as the leading cause of death worldwide, with stenosis, occlusion, or severe dysfunction blood vessels being its pathophysiological mechanism. Vascular replacement is preferred surgical option for treating obstructed vascular structures. Due to limited availability healthy autologous well incidence postoperative complications, there an increasing demand artificial vessels. From synthetic natural, a mixture these components, numerous materials have been used prepare grafts. Although grafts are more appropriate use in medium large-diameter vessels, they fail when replacing small-diameter Tissue-engineered very likely be ideal alternative and worthy further investigation. However, multitude problems remain that must resolved before can biomedical applications. Accordingly, this review attempts describe provide discussion generation In addition, we deliberate on current state-of-the-art technologies creating including advances materials, fabrication techniques, various methods surface modification, preclinical clinical Furthermore, evaluation both vivo vitro, mechanical properties, challenges, directions research also discussed.

Язык: Английский

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Three-dimensional bioprinting of artificial blood vessel: Process, bioinks, and challenges

International Journal of Bioprinting, Год журнала: 2023, Номер 9(4), С. 740 - 740

Опубликована: Апрель 28, 2023

The coronary artery bypass grafting is a main treatment for restoring the blood supply to ischemic site by bypassing narrow part, thereby improving heart function of patients. Autologous vessels are preferred in grafting, but their availability often limited due underlying disease. Thus, tissue-engineered vascular grafts that devoid thrombosis and have mechanical properties comparable those natural urgently required clinical applications. Most commercially available artificial implants made from polymers, which prone restenosis. biomimetic vessel containing tissue cells most ideal implant material. Due its precision control ability, three-dimensional (3D) bioprinting promising method prepare system. In 3D process, bioink at core state building topological structure keeping cell viable. Therefore, this review, basic viable materials discussed, research polymers bioink, including decellularized extracellular matrix, hyaluronic acid, collagen, emphasized. Besides, advantages alginate Pluronic F127, mainstream sacrificial material during preparation graft, also reviewed. Finally, an overview applications field presented.

Язык: Английский

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Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Biomolecules, Год журнала: 2023, Номер 13(9), С. 1389 - 1389

Опубликована: Сен. 14, 2023

The clinical demand for tissue-engineered vascular grafts is still rising, and there are many challenges that need to be overcome, in particular, obtain functional small-diameter grafts. advances made cell culture, biomaterials, manufacturing techniques, tissue engineering methods have led various promising solutions graft production, with available options able recapitulate both biological mechanical properties of native blood vessels. Due the rising interest materials bioactive potentials, from natural sources also recently gained more attention engineering, new strategies been developed solve disadvantages related their use. In this review, progress production discussed. We highlight, use as scaffolds engineering.

Язык: Английский

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