Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease

Biomolecules, Год журнала: 2024, Номер 14(7), С. 861 - 861

Опубликована: Июль 18, 2024

Congenital heart disease (CHD) is the most common birth defect, requiring invasive surgery often before a child’s first birthday. Current materials used during CHD lack ability to grow, remodel, and regenerate. To solve those limitations, 3D bioprinting an emerging tool with capability create tailored constructs based on patients’ own imaging data grow remodel once implanted in children CHD. It has potential integrate multiple bioinks several cell types biomolecules within 3D-bioprinted that exhibit good structural fidelity, stability, mechanical integrity. This review gives overview of recent advancements technologies use treatment Moreover, selection appropriate biomaterials their chemical, physical, biological properties are further manipulated suit application also discussed. An introduction bioink formulations composed various emphasis briefly overviewed. Vasculogenesis angiogenesis prefabricated structures novel 4D printing technology summarized. Finally, we discuss restrictions our perspective future directions

Язык: Английский

---

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Biomolecules, Год журнала: 2023, Номер 13(8), С. 1180 - 1180

Опубликована: Июль 28, 2023

Three-dimensional (3D) printing plays an important role in cardiovascular disease through the use of personalised models that replicate normal anatomy and its pathology with high accuracy reliability. While 3D printed heart vascular have been shown to improve medical education, preoperative planning simulation cardiac procedures, as well enhance communication patients, bioprinting represents a potential advancement technology by allowing cellular or biological components, functional tissues organs can be used variety applications disease. Recent advances ability support vascularisation large-scale constructs enhanced biocompatibility structural stability, thus creating opportunities replace damaged organs. In this review, we provide overview focus on technologies tissues, grafts, valves myocardium. Limitations future research directions are highlighted.

Язык: Английский

---

An assessment system for clinical and biological interpretability in ulcerative colitis

Aging, Год журнала: 2024, Номер 16(4), С. 3856 - 3879

Опубликована: Фев. 16, 2024

Aging | doi:10.18632/aging.205564. Shiqian Zhang, Ge Wenxiu Wang, Song-Bin Guo, Pengpeng Fuqi Quanbo Zhou, Zhaokai Yujia Haifeng Sun, Wenming Cui, Shuaixi Yang, Weitang Yuan

---

Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Decellularized artificial blood vessels prepared using physical and chemical methods often exhibit limitations, including poor mechanical performance, susceptibility to inflammation calcification, reduced patency. Cross‐linking techniques can enhance the stiffness, as well anti‐inflammatory anti‐calcification properties of decellularized vessels. However, conventional cross‐linking fail effectively alleviate residual stress post‐decellularization, which significantly impacts patency vascular remodeling following implantation This study enhances through varied conditions proanthocyanidin (PC) on Microstructural analysis investigations across various scales fresh, decellularized, stress‐recovered are performed atomic force microscopy (AFM), scanning electron (SEM), uniaxial tensile testing. Results demonstrate substantial alterations in morphology elastic collagen fibers remarkably resemble fresh recovery. Furthermore, both micro‐ macro‐mechanical characteristics post‐residual recovery, Young's modulus, viscoelasticity, adhesion, closely those Finite element modeling (FEM) confirms distribution its role enhancing integrity. experimental investigation provides a theoretical foundation at micro macroscopic levels for development biomimetic

Язык: Английский

---

Negative Poisson’s ratio artificial blood vessel skeleton multi-objective optimization design and numerical modelling

Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

In this study, a negative Poisson’s ratio honeycomb structure skeleton aimed at enhancing the mechanical properties of artificial blood vessels is proposed. The theoretical model was established, and key parameters influencing its were identified. optimal value intervals design points optimized determined using response surface methodology multi-objective genetic algorithm combined with finite element simulation software. accuracy parameter optimization analyzed by comparing results from various sample points. Subsequently, radial resilience analyzed. findings demonstrate that structural ratio, designed in exhibits favorable resilience.

Язык: Английский

---

Advances in three-dimensional printing of hydrogel formulations for vascularized tissue and organ regeneration

Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 43

Опубликована: Фев. 3, 2025

Over the last decades, three-dimensional (3D) printing has emerged as one of most promising alternative tissue and organ regeneration technologies. Recent advances in 3D technology, particularly hydrogel-derived bioink formulations, offer solutions for fabricating intricate, biomimetic scaffolds that promote vascularization. In this review, we presented numerous studies have been conducted to fabricate 3D-printed hydrogel vascularized constructs with significant advancements integumentary systems, cardiovascular bone tissues, skeletal muscles, livers, kidneys. Furthermore, work also discusses engineering considerations, current challenges, proposed solutions, future outlooks bioprinting.

Язык: Английский

---

Sensing the Future of Thrombosis Management: Integrating Vessel-on-a-Chip Models, Advanced Biosensors, and AI-Driven Digital Twins

ACS Sensors, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Thrombotic events, such as strokes and deep vein thrombosis, remain a significant global health burden, with traditional diagnostic methods often failing to capture the complex, patient-specific nuances of thrombosis risk. This Perspective explores revolutionary potential microengineered vessel-on-chip platforms in research personalized medicine. We discuss evolution from basic microfluidic channels advanced 3D-printed, models that accurately replicate complex vascular geometries, incorporating all elements Virchow's triad. Integrating these cutting-edge sensing technologies, including wearable ultrasonic devices electrochemical biosensors, enables real-time monitoring thrombosis-related parameters. Crucially, we highlight transformative role artificial intelligence digital twin technology leveraging vast data collected models. integration allows for development predictive algorithms twins, offering unprecedented risk assessment, treatment optimization, drug screening capabilities. The clinical relevance validation are examined, showcasing their predict thrombotic events guide strategies. While challenges scalability, standardization, regulatory approval persist, convergence platforms, sensing, AI-driven twins promises revolutionize management. approach paves way new era precision cardiovascular care, noninvasive, predictive, strategies prevention treatment, ultimately improving patient outcomes reducing burden diseases.

Язык: Английский

---

Graphene Oxide Modified Bioink for 3D-Bioprinting of Vascular Graft

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

Three-dimensional bioprinting (3DBP) has emerged as a promising technique for fabricating complex tissue constructs using bioinks that support cell growth and differentiation. However, the mechanical properties of remain critical challenge in this area, particularly vascular applications. Herein, combination an inorganic (nano)material [graphene oxide (GO)] with organic material (collagen) possible ingredients bioink intended graft was explored. Different formulations were developed compared terms rheology, printability, ability to 3D scaffolds. The modified collagen GO exhibited improved viscoelastic control formulation. Additionally, showed full vitro biocompatibility, no signs cytotoxicity. With future applications mind, series scaffolds successfully bioprinted proposed bioink. coculture human endothelial cells muscle (C2C12) demonstrated its potential In short, work introduces developing grafts enhanced biological properties.

Язык: Английский

---

Biomaterial-Based Additive Manufactured Composite Scaffolds for Tissue Engineering and Regenerative Medicine: A Comprehensive Review

Polymers, Год журнала: 2025, Номер 17(8), С. 1090 - 1090

Опубликована: Апрель 17, 2025

Additive manufacturing (AM), also referred to as three-dimensional printing/printed (3DP), has emerged a transformative approach in the current design and of various biomaterials for restoration damaged tissues inside body. This advancement greatly aided development customized biomedical devices including implants, prosthetics, orthotics that are specific patients. In tissue engineering (TE), AM enables fabrication complex structures promote desirable cellular responses regeneration tissues. Since choice plays vital role scaffold performance well responses, meticulous material selection is essential optimizing functionality scaffolds. These scaffolds often possess certain characteristics such biodegradability, biocompatibility, biomimicry, porous structure. To this end, polymers chitosan, collagen, alginate, hyaluronic acid, polyglycolic polylactic polycaprolactone have been extensively investigated tissue-engineered Furthermore, combinations utilized further enhance scaffolds’ functionality. review discusses principle explores recent advancements technologies TE regenerative medicine. addition, applications 3DP, polymer-based will be highlighted.

Язык: Английский

---

Rapid-Test Kit for Cardiac Troponin I: A Reliable Enzyme-Linked-Immuno-Substrate-Assay-Based Biosensor for Daily-Use Naked-Eye Detection and Pharmacokinetic Studies for Myocardial Infarction in Cardiovascular Disease

ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(8), С. 2369 - 2378

Опубликована: Июль 15, 2024

Myocardial infarction (MI) is a severe cardiovascular event that can lead to death. Cardiac troponin I (cTnI) an MI biomarker in the circulation system; however, methods for detecting cTnI protein require substantial time, tedious operations, expensive reader translating signals, and lot of reagents. This study aims create test kit with results easily distinguished by color differences, explicitly focusing on resolution between different concentrations eyes discern. These will aid creating commercial, portable, convenient, daily-use rapid-test kit. proposes biosensor naked eye perceive, performs diagnoses based pattern color, does not machine, easy operate, portable. Our device shortens diagnosis has 0.32–200 ng/mL quantitative analysis range human serum matrix, achieves 0.32 limit detection, exhibits many advantages compared traditional ELISA plate.

Язык: Английский

---