Current Analytical Chemistry,
Год журнала:
2023,
Номер
20(1), С. 2 - 13
Опубликована: Дек. 27, 2023
Abstract:
Sarcosine
is
currently
identified
as
a
potential
biomarker
for
prostate
cancer.
It
n-methyl
derivative
of
glycine,
which
naturally
present
in
muscle
and
body
tissues.
Studies
indicate
that
delay
the
treatment
cancer
often
due
to
its
diagnosis
not
being
possible
at
earlier
stages.
Also,
plasma
urine
samples
with
increased
sarcosine
concentration
exhibit
higher
probability
this
development,
therefore;
it
safe
proceed
them
biomarkers.
Correspondingly,
biosensor
can
be
used
early
detection
Driven
by
this,
review,
we
have
discussed
various
types
biosensors
sarcosine.
The
review
includes
an
overview
their
working
principle,
discussion
methodologies
used,
starting
from
conventional
chromatographic
methods
exclusive
nanotechnology-based
biosensors.
This
imbibes
techniques
involved
blood
samples.
We
also
critically
evaluated
different
reports
based
on
materials
employed,
limit
(LOD),
linear
range,
sensitivity,
cost.
believe
retains
novelty
providing
vision
existing
advancements
intricate
details
features,
thus
enabling
further
development
Critical Reviews in Clinical Laboratory Sciences,
Год журнала:
2024,
Номер
61(6), С. 473 - 495
Опубликована: Март 7, 2024
Nucleic
acids,
like
DNA
and
RNA,
serve
as
versatile
recognition
elements
in
electrochemical
biosensors,
demonstrating
notable
efficacy
detecting
various
cancer
biomarkers
with
high
sensitivity
selectivity.
These
biosensors
offer
advantages
such
cost-effectiveness,
rapid
response,
ease
of
operation,
minimal
sample
preparation.
This
review
provides
a
comprehensive
overview
recent
developments
nucleic
acid-based
for
diagnosis,
comparing
them
antibody-based
counterparts.
Specific
examples
targeting
key
biomarkers,
including
prostate-specific
antigen,
microRNA-21,
carcinoembryonic
are
highlighted.
The
discussion
delves
into
challenges
limitations,
encompassing
stability,
reproducibility,
interference,
standardization
issues.
suggests
future
research
directions,
exploring
new
acid
elements,
innovative
transducer
materials
designs,
novel
signal
amplification
strategies,
integration
microfluidic
devices
or
portable
instruments.
Evaluating
these
clinical
settings
using
actual
samples
from
patients
healthy
donors
is
emphasized.
sensors
sensitive
specific
at
non-communicable
communicable
disease
biomarkers.
RNA's
self-assembly,
programmability,
catalytic
activity,
dynamic
behavior
enable
adaptable
sensing
platforms.
They
can
increase
biosensor
biocompatibility,
transduction,
nanomaterials.
In
conclusion,
acids-based
hold
significant
potential
to
enhance
detection
treatment
through
early
accurate
diagnosis.
Future Microbiology,
Год журнала:
2024,
Номер
19(3), С. 281 - 291
Опубликована: Фев. 1, 2024
Pathogenic
microorganisms
pose
significant
threats
to
human
health,
food
safety
and
environmental
integrity.
Rapid
accurate
detection
of
these
pathogens
is
essential
mitigate
their
impact.
Fast,
sensitive
methods
such
as
biosensors
also
play
a
critical
role
in
preventing
outbreaks
controlling
spread.
In
recent
years,
have
emerged
revolutionary
technology
for
pathogen
detection.
This
review
aims
present
the
current
developments
biosensor
technology,
investigate
by
which
are
used
pathogenic
bacteria
highlight
future
perspectives
on
subject.
Viruses,
Год журнала:
2024,
Номер
16(2), С. 277 - 277
Опубликована: Фев. 10, 2024
Prostate
cancer
(PC)
is
the
second
most
diagnosed
among
men.
It
was
observed
that
early
diagnosis
of
disease
highly
beneficial
for
survival
patients.
Therefore,
extension
and
increasing
quality
life
PC
patients
can
be
achieved
by
broadening
screening
programs
are
aimed
at
identification
manifestation
in
earlier
stages,
before
they
demonstrate
well-understood
signs
disease.
there
an
urgent
need
standard,
sensitive,
robust,
commonly
available
tools
pathologies.
In
this
respect,
“Holy
Grail”
researchers
bioengineers
decades
has
been
molecular
sensing
probes
would
allow
diagnosis,
prognosis,
monitoring
diseases
via
their
interaction
with
cell-secreted
cell-associated
biomarkers,
e.g.,
PSA
PSMA,
respectively.
At
present,
tests
performed
centralized
laboratories
using
high-throughput
total
immune
analyzers,
which
suitable
dedicated
not
readily
broad
health
screenings.
current
trend
detection
development
portable
biosensors
mobile
individual
use.
Phage
display,
since
its
conception
George
Smith
1985,
emerged
as
a
premier
tool
biology
widespread
application.
This
review
describes
role
evolution
phage
display
paradigm
revolutionizing
methods
PC.
