Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 101047 - 101047
Published: Nov. 14, 2024
Language: Английский
Critical Reviews in Clinical Laboratory Sciences, Journal Year: 2024, Volume and Issue: 61(6), P. 473 - 495
Published: March 7, 2024
Nucleic acids, like DNA and RNA, serve as versatile recognition elements in electrochemical biosensors, demonstrating notable efficacy detecting various cancer biomarkers with high sensitivity selectivity. These biosensors offer advantages such cost-effectiveness, rapid response, ease of operation, minimal sample preparation. This review provides a comprehensive overview recent developments nucleic acid-based for diagnosis, comparing them antibody-based counterparts. Specific examples targeting key biomarkers, including prostate-specific antigen, microRNA-21, carcinoembryonic are highlighted. The discussion delves into challenges limitations, encompassing stability, reproducibility, interference, standardization issues. suggests future research directions, exploring new acid elements, innovative transducer materials designs, novel signal amplification strategies, integration microfluidic devices or portable instruments. Evaluating these clinical settings using actual samples from patients healthy donors is emphasized. sensors sensitive specific at non-communicable communicable disease biomarkers. RNA's self-assembly, programmability, catalytic activity, dynamic behavior enable adaptable sensing platforms. They can increase biosensor biocompatibility, transduction, nanomaterials. In conclusion, acids-based hold significant potential to enhance detection treatment through early accurate diagnosis.
Language: Английский
Citations
10
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113172 - 113172
Published: Feb. 1, 2025
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2023, Volume and Issue: 439, P. 138145 - 138145
Published: Dec. 5, 2023
Language: Английский
Citations
18
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 557, P. 117882 - 117882
Published: March 21, 2024
Language: Английский
Citations
8
Future Microbiology, Journal Year: 2024, Volume and Issue: 19(3), P. 281 - 291
Published: Feb. 1, 2024
Pathogenic microorganisms pose significant threats to human health, food safety and environmental integrity. Rapid accurate detection of these pathogens is essential mitigate their impact. Fast, sensitive methods such as biosensors also play a critical role in preventing outbreaks controlling spread. In recent years, have emerged revolutionary technology for pathogen detection. This review aims present the current developments biosensor technology, investigate by which are used pathogenic bacteria highlight future perspectives on subject.
Language: Английский
Citations
7
Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 277 - 277
Published: Feb. 10, 2024
Prostate cancer (PC) is the second most diagnosed among men. It was observed that early diagnosis of disease highly beneficial for survival patients. Therefore, extension and increasing quality life PC patients can be achieved by broadening screening programs are aimed at identification manifestation in earlier stages, before they demonstrate well-understood signs disease. there an urgent need standard, sensitive, robust, commonly available tools pathologies. In this respect, “Holy Grail” researchers bioengineers decades has been molecular sensing probes would allow diagnosis, prognosis, monitoring diseases via their interaction with cell-secreted cell-associated biomarkers, e.g., PSA PSMA, respectively. At present, tests performed centralized laboratories using high-throughput total immune analyzers, which suitable dedicated not readily broad health screenings. current trend detection development portable biosensors mobile individual use. Phage display, since its conception George Smith 1985, emerged as a premier tool biology widespread application. This review describes role evolution phage display paradigm revolutionizing methods PC.
Language: Английский
Citations
7
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105568 - 105568
Published: March 16, 2024
Language: Английский
Citations
6
Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(9), P. 2277 - 2300
Published: Jan. 27, 2024
Language: Английский
Citations
5
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 254, P. 116204 - 116204
Published: March 16, 2024
Language: Английский
Citations
5
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2596 - 2604
Published: April 29, 2024
Cancer stands as a prominent global cause of mortality, necessitating early detection to augment survival rates and alleviate economic burdens on healthcare systems. In particular, prostate cancer (PCa), impacting 1.41 million men globally in 2020, accentuates the demand for sensitive cost-effective methods beyond traditional prostate-specific antigen (PSA) testing. While clinical techniques exhibit limitations, biosensors emerge compact, user-friendly alternatives laboratory approaches. However, existing predominantly concentrate PSA detection, prompting necessity advancing toward multiplex sensing platforms. This study introduces compact opto-microfluidic sensor featuring substrate gold nanospikes, fabricated via electrodeposition, enhanced sensitivity. Embedded within microfluidic chip, this nanomaterial enables precise concurrent measurement PSA, alongside two complementary PCa biomarkers, matrix metalloproteinase-2 (MMP-2) anti-α-methylacyl-CoA racemase (anti-AMACR) diluted human plasma, offering comprehensive approach analysis. Taking advantage localized surface plasmon resonance principle, biosensor offers robustness sensitivity real sample analysis without need labeling agents. With limit at 0.22, 0.37, 0.18 ng/mL MMP-2, anti-AMACR, respectively, biosensing platform holds promise point-of-care analysis, underscoring its potential impact medical diagnostics.
Language: Английский
Citations
5