Exosome-Laden Hydrogels as Promising Carriers for Oral and Bone Tissue Engineering: Insight into Cell-Free Drug Delivery

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11092 - 11092

Опубликована: Окт. 15, 2024

Mineralization is a key biological process that required for the development and repair of tissues such as teeth, bone cartilage. Exosomes (Exo) are subset extracellular vesicles (~50–150 nm) secreted by cells contain genetic material, proteins, lipids, nucleic acids, other substances have been extensively researched oral tissue regeneration. However, Exo-free biomaterials or exosome treatments exhibit poor bioavailability lack controlled release mechanisms at target site during By encapsulating Exos into like hydrogels, these disadvantages can be mitigated. Several engineering approaches, those wound healing processes in diabetes mellitus, treatment osteoarthritis (OA) cartilage degeneration, intervertebral disc cardiovascular diseases, etc., exploited to deliver exosomes containing variety therapeutic diagnostic cargos tissues. Despite significant efficacy Exo-laden their use mineralized tissues, tissue, very sparse. This review aims explore summarize literature related potential hydrogel-encapsulated provides insight practical procedures future clinical techniques.

Язык: Английский

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Advances and prospects of RNA delivery nanoplatforms for cancer therapy

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(1), С. 52 - 96

Опубликована: Сен. 14, 2024

Modern oncology is rapidly evolving, driven by recent advances in RNA-based therapeutics. As new emerging cutting-edge technology, mRNA vaccines hold excellent promise for encoding immunostimulatory molecules, tumor-associated antigens, neoantigens, and chimeric antigen receptors T-cell reprogramming. RNA interference tools enable highly effective post-transcriptional gene silencing that has progressed towards more tailored antitumor treatments targeting key molecular players tumor progression drug resistance. The inherent challenges limitations of tools, such as size, low stability surface charges hindering direct cell entry, along with the short circulatory half-life rapid clearance, call improved delivery systems enabling enhanced delivery. Nanoplatforms, particularly certain types lipid, polymeric nanoparticles inorganic nanoparticles, provide designed means to address cellular uptake. This paper explores barriers while giving insight into future perspective cancer therapeutics context nanoplatforms during development.

Язык: Английский

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Breakthrough in large-scale production of iPSCs-derived exosomes to promote clinical applications

Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11

Опубликована: Авг. 24, 2023

OPINION article Front. Bioeng. Biotechnol., 24 August 2023Sec. Biofabrication Volume 11 - 2023 | https://doi.org/10.3389/fbioe.2023.1257186

Язык: Английский

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Engineered extracellular vesicles for cancer drug delivery and therapeutics

Current Opinion in Physiology, Год журнала: 2024, Номер 39, С. 100755 - 100755

Опубликована: Апрель 23, 2024

Язык: Английский

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Electrospinning process: fiber composition and applications

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 719 - 744

Опубликована: Янв. 1, 2024

Язык: Английский

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Engineered local delivery of extracellular vesicles loaded with si-TNF-α, via a core-sheath 3D-bio-printed scaffold as an effective wound dressing

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106189 - 106189

Опубликована: Сен. 1, 2024

Язык: Английский

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