Emerging role of exosomes in cancer therapy: progress and challenges

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Язык: Английский

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Recent advances in scaffolding biomaterials for cultivated meat

Biomaterials Advances, Год журнала: 2024, Номер 162, С. 213897 - 213897

Опубликована: Май 21, 2024

Язык: Английский

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Exosomal Cargo: Pro-angiogeneic, anti-inflammatory, and regenerative effects in ischemic and non-ischemic heart diseases – A comprehensive review

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115801 - 115801

Опубликована: Окт. 31, 2023

Heart diseases are the primary cause of mortality and morbidity worldwide which inflict a heavy social economic burden. Among heart diseases, most deaths due to myocardial infarction (MI) or attack, occurs when decrement in blood flow causes injury cardiac tissue. Despite several available diagnostic, therapeutic, prognostic approaches, disease remains significant concern. Exosomes kind small extracellular vesicles released by different types cells that play part intercellular communication transferring bioactive molecules important regenerative medicine. Many studies have reported role exosomes various diseases. Herein, we reviewed roles as new emerging agents including ischemic disease, cardiomyopathy, arrhythmia, valvular focusing on pathogenesis, areas. We also mentioned routes exosome delivery target tissues, effects preconditioning modification exosome's capability, production compliance with good manufacturing practice (GMP), their ongoing clinical applications medical contexts shed light possible translation.

Язык: Английский

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Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage

Translational Stroke Research, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 25, 2023

Язык: Английский

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