Artificial Intelligence and the Internal Processes of Creativity
The Journal of Creative Behavior,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
ABSTRACT
Artificial
intelligence
(AI)
systems
capable
of
generating
creative
outputs
are
reshaping
our
understanding
creativity.
This
shift
presents
an
opportunity
for
creativity
researchers
to
reevaluate
the
key
components
process.
In
particular,
advanced
capabilities
AI
underscore
importance
studying
internal
processes
paper
explores
neurobiological
machinery
that
underlies
these
and
describes
experiential
component
It
is
concluded
although
products
artificial
human
can
be
similar,
different.
The
also
discusses
how
may
negatively
affect
creativity,
such
as
development
skills,
authenticity
diversity
ideas.
Язык: Английский
Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans
Frontiers in Neural Circuits,
Год журнала:
2025,
Номер
18
Опубликована: Янв. 9, 2025
The
substantia
nigra
pars
compacta
(SNc),
one
of
the
main
dopaminergic
nuclei
brain,
exerts
a
regulatory
function
on
basal
ganglia
circuitry
via
nigro-striatal
pathway
but
its
possible
innervation
thalamus
has
been
only
investigated
in
non-human
primates.
impossibility
tract-tracing
studies
humans
boosted
advanced
MRI
techniques
and
multi-shell
high-angular
resolution
diffusion
(MS-HARDI)
promised
to
shed
more
light
structural
connectivity
subcortical
structures.
Here,
we
estimated
human
an
MS-HARDI
tractography
SNc
healthy
young
adults.
Two
data
sets
were
serially
acquired
using
schemes
from
ADNI
HCP
neuroimaging
initiatives
group
10
subjects
(5
males,
age
range:
25-30
years).
High
3D-T1
images
independently
individually
segment
SNc.
Starting
whole-brain
probabilistic
tractography,
all
streamlines
through
reaching
counted,
separately
for
each
hemisphere,
after
excluding
reticulata
those
ganglia,
cerebellum
cortex.
We
found
reproducible
between
thalamus,
with
average
~12%
total
number
encompassing
terminating
no
other
major
or
cortical
structures
involved.
first
principal
component
map
dopamine
receptor
density
normative
PET
image
set
suggested
similar
levels
across
thalamus.
This
is
quantitative
report
in-vivo
measurements
supporting
presence
direct
nigro-thalamic
projection.
While
histological
validation
concurrent
PET-MRI
remains
needed
ultimate
proofing
existence,
given
potential
role
this
pathway,
possibility
achieve
good
reproducibility
these
might
enable
monitoring
dopaminergic-related
disorders,
towards
targeted
personalized
therapies.
Язык: Английский
Adaptive learning via BG-thalamo-cortical circuitry
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
People
adjust
their
use
of
feedback
over
time
through
a
process
referred
to
as
adaptive
learning.
We
have
recently
proposed
that
the
underlying
mechanisms
learning
are
rooted
in
how
brain
organizes
into
similarly
credited
units,
which
we
refer
latent
states.
Here
develop
BG-thalamo-cortical
circuit
model
this
and
show
it
captures
both
commonalities
heterogeneity
human
behavior.
Our
learns
incrementally
synaptic
plasticity
PFC-BG
connections,
but
upon
observing
discordant
information,
produces
thalamocortical
reset
signals
alter
PFC
connectivity,
driving
attractor
state
transitions
facilitate
rapid
updating
behavioral
policy.
demonstrate
mechanism
can
give
rise
optimized
dynamics
context
either
changepoints
or
reversals,
under
reasonable
biological
assumptions
is
able
generalize
efficiently
across
these
conditions,
adjusting
behavior
context-appropriate
manner.
Taken
together,
our
results
provide
biologically
plausible
mechanistic
for
explains
existing
data
makes
testable
predictions
about
computational
roles
different
regions
complex
behaviors.
Язык: Английский
Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 18, 2025
The
mediodorsal
(MD)
thalamus
is
a
critical
partner
for
the
prefrontal
cortex
(PFC)
in
cognitive
control.
Accumulating
evidence
has
shown
that
MD
regulates
task
uncertainty
decision
making
and
enhance
flexibility.
However,
computational
mechanism
of
this
process
remains
unclear.
Here
we
trained
biologically-constrained
models
to
delineate
mechanistic
role
context-dependent
making.
We
show
addition
feedforward
structure
recurrent
PFC
increases
robustness
low
cueing
signal-to-noise
ratio,
enhances
working
memory,
enables
rapid
context
switching.
Incorporating
genetically
identified
thalamocortical
connectivity
interneuron
cell
types
into
model
replicates
key
neurophysiological
findings
task-performing
animals.
Our
reveals
mechanisms
geometric
interpretations
regulating
cue
switching
enable
makes
experimentally
testable
predictions
linking
deficits
with
disrupted
connectivity,
excitation-inhibition
imbalance
dysfunctional
inhibitory
types.
by
which
activity
flexibility
not
fully
understood.
authors
build
incorporating
Together
experimental
testing,
circuit
Язык: Английский
Developing algorithmic psychiatry via multi-level spanning computational models
Cell Reports Medicine,
Год журнала:
2025,
Номер
unknown, С. 102094 - 102094
Опубликована: Апрель 1, 2025
Язык: Английский
Prefrontal transthalamic uncertainty processing drives flexible switching
Nature,
Год журнала:
2024,
Номер
637(8044), С. 127 - 136
Опубликована: Ноя. 13, 2024
Язык: Английский
A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia
Cell Reports Medicine,
Год журнала:
2024,
Номер
5(11), С. 101802 - 101802
Опубликована: Ноя. 1, 2024
Highlights•Developed
a
task
to
interrogate
allocating
attention
with
conflicting
inputs•People
schizophrenia
are
more
susceptible
inputs•Right
MD-dlPFC
functional
connectivity
as
readout
for
conflict-related
executive
deficitSummaryExecutive
dysfunction
is
prominent
feature
of
and
may
drive
core
symptoms.
Dorsolateral
prefrontal
cortex
(dlPFC)
deficits
have
been
linked
dysfunction,
but
mechanistic
details
critical
treatment
development
remain
unclear.
Here,
capitalizing
on
recent
animal
circuit
studies,
we
develop
predicted
engage
human
dlPFC
its
interactions
the
mediodorsal
thalamus
(MD).
We
find
that
individuals
exhibit
selective
performance
when
guided
by
cues.
Task
correlates
lateralized
connectivity,
identifying
neural
predicts
susceptibility
conflict
during
working
memory
in
larger
independent
cohort.
In
healthy
subjects
performing
probabilistic
reversal
task,
this
network
switching
behavior.
Overall,
our
three
experiments
introduce
putative
biomarkers
function
highlight
studies
inspiration
clinically
relevant
readouts.Graphical
abstract
Язык: Английский
Cortico-subcortical dynamics in primate working memory
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
Working
memory
is
essential
for
cognition,
facilitating
the
temporary
maintenance
and
manipulation
of
information
to
produce
goal-directed
behavior.
While
both
cortical
subcortical
structures
are
involved,
their
precise
roles
interactions
not
fully
understood.
To
investigate
this,
we
simultaneously
recorded
neural
activity
from
frontal
parietal
cortex,
higher-order
thalamic
nuclei,
core
basal
ganglia
during
color
spatial
working
tasks
in
non-human
primates.
We
found
widespread
yet
differential
encoding
information,
marked
by
area-specific
temporal
dynamics
modulation
according
task
demands.
Both
increased
towards
memory-dependent
actions,
suggesting
a
task-specific
reloading
information.
Directed
between
regions
were
extensive
reciprocal,
with
dominant
directions
flow,
especially
frontoparietal
areas.
These
dynamically
modulated
partially
specific.
Our
findings
provide
comprehensive
insights
into
large-scale
circuit
underlying
primate
suggest
that
flexible
behavior
relies
on
selective
processing
task-relevant
within
information-specific
cortico-subcortical
networks.
Язык: Английский