Cortico-subcortical dynamics in primate working memory DOI Creative Commons
Constantin von Nicolai, Markus Siegel

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Working memory is essential for cognition, facilitating the temporary maintenance and manipulation of information to produce goal-directed behavior. While both cortical subcortical structures are involved, their precise roles interactions not fully understood. To investigate this, we simultaneously recorded neural activity from frontal parietal cortex, higher-order thalamic nuclei, core basal ganglia during color spatial working tasks in non-human primates. We found widespread yet differential encoding information, marked by area-specific temporal dynamics modulation according task demands. Both increased towards memory-dependent actions, suggesting a task-specific reloading information. Directed between regions were extensive reciprocal, with dominant directions flow, especially frontoparietal areas. These dynamically modulated partially specific. Our findings provide comprehensive insights into large-scale circuit underlying primate suggest that flexible behavior relies on selective processing task-relevant within information-specific cortico-subcortical networks.

Language: Английский

Artificial Intelligence and the Internal Processes of Creativity DOI
Jaan Aru

The Journal of Creative Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

ABSTRACT Artificial intelligence (AI) systems capable of generating creative outputs are reshaping our understanding creativity. This shift presents an opportunity for creativity researchers to reevaluate the key components process. In particular, advanced capabilities AI underscore importance studying internal processes paper explores neurobiological machinery that underlies these and describes experiential component It is concluded although products artificial human can be similar, different. The also discusses how may negatively affect creativity, such as development skills, authenticity diversity ideas.

Language: Английский

Citations

2
Evidence for direct dopaminergic connections between substantia nigra pars compacta and thalamus in young healthy humans DOI Creative Commons
Giovanni Cirillo, Giuseppina Caiazzo,

Federica Franza

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 9, 2025

The substantia nigra pars compacta (SNc), one of the main dopaminergic nuclei brain, exerts a regulatory function on basal ganglia circuitry via nigro-striatal pathway but its possible innervation thalamus has been only investigated in non-human primates. impossibility tract-tracing studies humans boosted advanced MRI techniques and multi-shell high-angular resolution diffusion (MS-HARDI) promised to shed more light structural connectivity subcortical structures. Here, we estimated human an MS-HARDI tractography SNc healthy young adults. Two data sets were serially acquired using schemes from ADNI HCP neuroimaging initiatives group 10 subjects (5 males, age range: 25-30 years). High 3D-T1 images independently individually segment SNc. Starting whole-brain probabilistic tractography, all streamlines through reaching counted, separately for each hemisphere, after excluding reticulata those ganglia, cerebellum cortex. We found reproducible between thalamus, with average ~12% total number encompassing terminating no other major or cortical structures involved. first principal component map dopamine receptor density normative PET image set suggested similar levels across thalamus. This is quantitative report in-vivo measurements supporting presence direct nigro-thalamic projection. While histological validation concurrent PET-MRI remains needed ultimate proofing existence, given potential role this pathway, possibility achieve good reproducibility these might enable monitoring dopaminergic-related disorders, towards targeted personalized therapies.

Language: Английский

Citations

0
Adaptive learning via BG-thalamo-cortical circuitry DOI Creative Commons
Qin He, Daniel N. Scott, Michael J. Frank

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

People adjust their use of feedback over time through a process referred to as adaptive learning. We have recently proposed that the underlying mechanisms learning are rooted in how brain organizes into similarly credited units, which we refer latent states. Here develop BG-thalamo-cortical circuit model this and show it captures both commonalities heterogeneity human behavior. Our learns incrementally synaptic plasticity PFC-BG connections, but upon observing discordant information, produces thalamocortical reset signals alter PFC connectivity, driving attractor state transitions facilitate rapid updating behavioral policy. demonstrate mechanism can give rise optimized dynamics context either changepoints or reversals, under reasonable biological assumptions is able generalize efficiently across these conditions, adjusting behavior context-appropriate manner. Taken together, our results provide biologically plausible mechanistic for explains existing data makes testable predictions about computational roles different regions complex behaviors.

Language: Английский

Citations

0
Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility DOI Creative Commons
Xiaohan Zhang, Arghya Mukherjee, Michael M. Halassa

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

The mediodorsal (MD) thalamus is a critical partner for the prefrontal cortex (PFC) in cognitive control. Accumulating evidence has shown that MD regulates task uncertainty decision making and enhance flexibility. However, computational mechanism of this process remains unclear. Here we trained biologically-constrained models to delineate mechanistic role context-dependent making. We show addition feedforward structure recurrent PFC increases robustness low cueing signal-to-noise ratio, enhances working memory, enables rapid context switching. Incorporating genetically identified thalamocortical connectivity interneuron cell types into model replicates key neurophysiological findings task-performing animals. Our reveals mechanisms geometric interpretations regulating cue switching enable makes experimentally testable predictions linking deficits with disrupted connectivity, excitation-inhibition imbalance dysfunctional inhibitory types. by which activity flexibility not fully understood. authors build incorporating Together experimental testing, circuit

Language: Английский

Citations

0
Developing algorithmic psychiatry via multi-level spanning computational models DOI Creative Commons
Michael M. Halassa, Michael J. Frank, Philippa Garety

et al.

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102094 - 102094

Published: April 1, 2025

Language: Английский

Citations

0
Prefrontal transthalamic uncertainty processing drives flexible switching DOI
Norman H. Lam, Arghya Mukherjee, Ralf Wimmer

et al.

Nature, Journal Year: 2024, Volume and Issue: 637(8044), P. 127 - 136

Published: Nov. 13, 2024

Language: Английский

Citations

2
A prefrontal thalamocortical readout for conflict-related executive dysfunction in schizophrenia DOI Creative Commons
Anna Huang, Ralf Wimmer, Norman H. Lam

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101802 - 101802

Published: Nov. 1, 2024

Highlights•Developed a task to interrogate allocating attention with conflicting inputs•People schizophrenia are more susceptible inputs•Right MD-dlPFC functional connectivity as readout for conflict-related executive deficitSummaryExecutive dysfunction is prominent feature of and may drive core symptoms. Dorsolateral prefrontal cortex (dlPFC) deficits have been linked dysfunction, but mechanistic details critical treatment development remain unclear. Here, capitalizing on recent animal circuit studies, we develop predicted engage human dlPFC its interactions the mediodorsal thalamus (MD). We find that individuals exhibit selective performance when guided by cues. Task correlates lateralized connectivity, identifying neural predicts susceptibility conflict during working memory in larger independent cohort. In healthy subjects performing probabilistic reversal task, this network switching behavior. Overall, our three experiments introduce putative biomarkers function highlight studies inspiration clinically relevant readouts.Graphical abstract

Language: Английский

Citations

1
Cortico-subcortical dynamics in primate working memory DOI Creative Commons
Constantin von Nicolai, Markus Siegel

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Working memory is essential for cognition, facilitating the temporary maintenance and manipulation of information to produce goal-directed behavior. While both cortical subcortical structures are involved, their precise roles interactions not fully understood. To investigate this, we simultaneously recorded neural activity from frontal parietal cortex, higher-order thalamic nuclei, core basal ganglia during color spatial working tasks in non-human primates. We found widespread yet differential encoding information, marked by area-specific temporal dynamics modulation according task demands. Both increased towards memory-dependent actions, suggesting a task-specific reloading information. Directed between regions were extensive reciprocal, with dominant directions flow, especially frontoparietal areas. These dynamically modulated partially specific. Our findings provide comprehensive insights into large-scale circuit underlying primate suggest that flexible behavior relies on selective processing task-relevant within information-specific cortico-subcortical networks.

Language: Английский

Citations

0