Deepm6A-MT: A deep learning-based method for identifying RNA N6-methyladenosine sites in multiple tissues DOI
Guohua Huang,

Xiaohong Huang,

Jinyun Jiang

и другие.

Methods, Год журнала: 2024, Номер 226, С. 1 - 8

Опубликована: Март 12, 2024

Язык: Английский

Identification of ALYREF in pan cancer as a novel cancer prognostic biomarker and potential regulatory mechanism in gastric cancer DOI Creative Commons
Yujie Yuan,

Yiyang Fan,

Wenqing Tang

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 15, 2024

ALYREF is considered as a specific mRNA m5C-binding protein which recognizes m5C sites in RNA and facilitates the export of from nucleus to cytoplasm. Expressed various tissues highly involved transcriptional regulation, has potential become novel diagnostic marker therapeutic target for cancer patients. However, few studies focused on its function during carcinogenesis progress. In order explore role tumorigenesis, TCGA GTEx databases were used investigate relationship pan-cancer. We found that was expressed majority types elevated expression level positively associated with poor prognosis many cancers. GO KEGG analysis showed be essential regulating cell cycle gene mismatch repair tumor progression. The correlation heterogeneity indicated could specially correlated stemness stomach adenocarcinoma (STAD). Furthermore, we gastric carcinogenesis. Prognostic different molecular subtypes (GC) unfolded high leads certain GC. Finally, enrichment revealed ALYREF-related genes possess apoptosis cause further influences GC For verification, knocked down by siRNA line AGS. Knockdown distinctly contributed inhibition proliferation. Moreover, it observed knocked-down induced AGS cells arrested G1 phase increased apoptosis. Our findings highlighted tumorigenesis contribution through pan-cancer biological experiments.

Язык: Английский

Процитировано

7
Exploring the role of m7G modification in Cancer: Mechanisms, regulatory proteins, and biomarker potential DOI
Yu Zhang,

Weihao Xu,

Chuanhui Peng

и другие.

Cellular Signalling, Год журнала: 2024, Номер 121, С. 111288 - 111288

Опубликована: Июль 5, 2024

Язык: Английский

Процитировано

7
Overcoming Antigen Escape and T-Cell Exhaustion in CAR-T Therapy for Leukemia DOI Creative Commons
Elżbieta Bartoszewska, Maciej Tota, Monika Kisielewska

и другие.

Cells, Год журнала: 2024, Номер 13(18), С. 1596 - 1596

Опубликована: Сен. 23, 2024

Leukemia is a prevalent pediatric cancer with significant challenges, particularly in relapsed or refractory cases. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as personalized treatment, modifying patients' T cells to target and destroy resistant cells. This study reviews the current therapeutic options of CAR-T for leukemia, addressing primary obstacles such escape exhaustion. We explore dual-targeting strategies their potential improve treatment outcomes by preventing loss antigens. Additionally, we examine mechanisms exhaustion enhance persistence effectiveness. Despite remarkable clinical successes, poses risks cytokine release syndrome (CRS) immune effector cell-associated neurotoxicity (ICANS). Our findings highlight need ongoing research optimize applications, reduce toxicities, extend this innovative broader range hematologic malignancies. comprehensive review aims provide valuable insights improving leukemia advancing field immunotherapy.

Язык: Английский

Процитировано

7
Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways DOI

Chaitanya Sree Somala,

S. Sathyapriya,

Nagaraj Bharathkumar

и другие.

The Protein Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Язык: Английский

Процитировано

1
Deepm6A-MT: A deep learning-based method for identifying RNA N6-methyladenosine sites in multiple tissues DOI
Guohua Huang,

Xiaohong Huang,

Jinyun Jiang

и другие.

Methods, Год журнала: 2024, Номер 226, С. 1 - 8

Опубликована: Март 12, 2024

Язык: Английский

Процитировано

6