Exploring the role of endogenous retroviruses in seasonal reproductive cycles: a case study of the ERV-V envelope gene in mink DOI Creative Commons
Yufei Zhang, Gaofeng Wang, Yanzhu Zhu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Июнь 28, 2024

Introduction Endogenous retroviruses (ERVs), which originated from exogenous retroviral infections of germline cells millions years ago and were inherited by subsequent generations as per Mendelian inheritance patterns, predominantly comprise non-protein-coding sequences due to the accumulation mutations, insertions, deletions, truncations. Nevertheless, recent studies have revealed that ERVs play a crucial role in diverse biological processes encoding various proteins. Methods In this study, we successfully identified an ERV envelope (env ) gene mink species. A phylogenetic tree ERV-V env reference was constructed using Bayesian methods maximum-likelihood inference. Results Phylogenetic analyses indicated significant degree sequence conservation positive selection within -surface open reading frame. Additionally, qRT-PCR patterns expression tissues. The testicular tissue strongly correlated with seasonal reproductive cycles minks. Discussion Our study suggests may been repurposed for host functions.

Язык: Английский

Transcription of Endogenous Retroviruses: Broad and Precise Mechanisms of Control DOI Creative Commons

Abigail Jarosz,

Julia V. Halo

Viruses, Год журнала: 2024, Номер 16(8), С. 1312 - 1312

Опубликована: Авг. 17, 2024

Endogenous retroviruses (ERVs) are the remnants of retroviral germline infections and highly abundant in genomes vertebrates. At one time considered to be nothing more than inert ‘junk’ within genomes, ERVs have been tolerated host over vast timescales, their study continues reveal complex co-evolutionary histories respective species. For example, multiple instances characterized having ‘borrowed’ for normal physiology, from single copies ones involved various regulatory networks such as innate immunity during early development. Within cell, accessibility is normally tightly controlled by epigenetic mechanisms DNA methylation or histone modifications. However, these silencing reversible, alterations chromatin landscape can thus lead aberrant expression, observed abnormal cellular environments tumors. In this review, we focus on ERV transcriptional control draw parallels distinctions concerning loss regulation disease, well precise

Язык: Английский

Процитировано

3
Dual roles of human endogenous retroviruses in cancer progression and antitumor immune response DOI
S.Y. Cindy Yang,

Surong Dong,

Benshuai You

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189201 - 189201

Опубликована: Окт. 18, 2024

Язык: Английский

Процитировано

1
Exploring the role of endogenous retroviruses in seasonal reproductive cycles: a case study of the ERV-V envelope gene in mink DOI Creative Commons
Yufei Zhang, Gaofeng Wang, Yanzhu Zhu

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Июнь 28, 2024

Introduction Endogenous retroviruses (ERVs), which originated from exogenous retroviral infections of germline cells millions years ago and were inherited by subsequent generations as per Mendelian inheritance patterns, predominantly comprise non-protein-coding sequences due to the accumulation mutations, insertions, deletions, truncations. Nevertheless, recent studies have revealed that ERVs play a crucial role in diverse biological processes encoding various proteins. Methods In this study, we successfully identified an ERV envelope (env ) gene mink species. A phylogenetic tree ERV-V env reference was constructed using Bayesian methods maximum-likelihood inference. Results Phylogenetic analyses indicated significant degree sequence conservation positive selection within -surface open reading frame. Additionally, qRT-PCR patterns expression tissues. The testicular tissue strongly correlated with seasonal reproductive cycles minks. Discussion Our study suggests may been repurposed for host functions.

Язык: Английский

Процитировано

0