Apmis,
Год журнала:
2024,
Номер
132(12), С. 1106 - 1114
Опубликована: Апрель 24, 2024
Malassezia
furfur
is
a
yeast
known
as
the
etiological
agent
of
seborrheic
dermatitis.
We
evaluated
action
five
different
antimicrobials
(amphotericin
B,
chloramphenicol,
ketoconazole,
fluconazole,
and
nystatin)
on
inhibiting
biofilm
formation
removing
already
formed
by
M.
furfur.
The
assays
were
carried
out
using
microdilution
method,
scanning
electron
microscopy
images
used
to
analyze
structure.
According
results
obtained,
percentage
inhibition
was
higher
for
followed
nystatin,
amphotericin
B.
Regarding
eradication
formed,
highest
ketoconazole
nystatin.
Amphotericin
B
did
not
affect
eradication,
whereas
fluconazole
cause
significant
changes
or
biofilm.
Therefore,
except
all
had
effects
furfur,
either
in
its
and/or
eradication.
Although
achieved
with
chloramphenicol
have
been
highlighted,
further
vitro
vivo
studies
are
still
needed
order
include
this
antimicrobial
therapy
dermatitis
due
toxicity,
especially
bone
marrow.
The
postoperative
burden
remains
significant
due
to
the
possibility
of
prolonged
hospitalization,
escalated
healthcare
costs,
and
patient
distress
caused
by
postorthopedic
surgical
site
infections
(SSIs).
Orthopedic
surgery
is
likewise
faced
with
a
challenge
posed
these
conditions.
A
positive
association
has
been
observed
between
presence
SSIs
heightened
susceptibility
adverse
health
outcomes,
along
elevated
rates
morbidity
mortality.
Systemic
antibiotic
prophylaxis
(SAP)
reduces
risk
acquiring
an
SSI.
Closed
fractures,
open
arthroplasty,
percutaneous
fixation
each
possess
distinct
attributes
that
impact
data
antimicrobial
therapy.
When
implementing
SAP,
it
crucial
strike
delicate
equilibrium
maintaining
effective
stewardship
protocols
preventing
occurrence
SSIs.
This
practice
effectively
prevents
both
incidence
negative
consequences
emergence
resistance.
objective
this
study
was
examine
existing
literature
on
use
in
orthopedic
explore
potential
associated
inappropriate
administration
antibiotics.
Apmis,
Год журнала:
2024,
Номер
132(12), С. 1106 - 1114
Опубликована: Апрель 24, 2024
Malassezia
furfur
is
a
yeast
known
as
the
etiological
agent
of
seborrheic
dermatitis.
We
evaluated
action
five
different
antimicrobials
(amphotericin
B,
chloramphenicol,
ketoconazole,
fluconazole,
and
nystatin)
on
inhibiting
biofilm
formation
removing
already
formed
by
M.
furfur.
The
assays
were
carried
out
using
microdilution
method,
scanning
electron
microscopy
images
used
to
analyze
structure.
According
results
obtained,
percentage
inhibition
was
higher
for
followed
nystatin,
amphotericin
B.
Regarding
eradication
formed,
highest
ketoconazole
nystatin.
Amphotericin
B
did
not
affect
eradication,
whereas
fluconazole
cause
significant
changes
or
biofilm.
Therefore,
except
all
had
effects
furfur,
either
in
its
and/or
eradication.
Although
achieved
with
chloramphenicol
have
been
highlighted,
further
vitro
vivo
studies
are
still
needed
order
include
this
antimicrobial
therapy
dermatitis
due
toxicity,
especially
bone
marrow.
