The Transmitter, Год журнала: 2023, Номер unknown
Опубликована: Янв. 1, 2023
The drug bumetanide had no effect on autism traits in children two clinical trials.
Язык: Английский
Molecular Medicine, Год журнала: 2025, Номер 31(1)
Опубликована: Май 20, 2025
Abstract Autism spectrum disorder (ASD) affects approximately 1% of the population directly, but also a much higher proportion (family and caregivers) indirectly. Although ASD is characterized by high prevalence anxiety poor gastrointestinal health, current treatment strategies are mainly focused on neurological symptomatic treatment, with little to no attention gut health. Furthermore, many psychiatric drugs used for management secondary symptoms, known exacerbate health issues dysregulation across gut-brain axis. Trace amines neurotransmitter-like substances synthesized endogenously in human brain – trace amounts abundance microbiome. Emerging evidence suggests amine system ASD. Since aminergic signalling central regulatory homeostasis, we hypothesize targeting this context. Given various sources amines, suggest that normalization functional dysbiosis terms rather than microbial compositional should be focus medicines development. In addition, holistic consideration including other factors at play determining outcome such as receptor binding, enzymatic role players, etc. required fully elucidate therapeutically modify pathophysiology systems implicated This review firstly provides brief overview Secondly, formulate our hypothesis how may address symptomology, cellular molecular mechanism interplay Finally, provide critical assessment advances therapeutics development drug re-purposing, gaps knowledge priorities going forward.
Язык: Английский
Процитировано
0
Brain Behavior and Immunity, Год журнала: 2025, Номер 129, С. 126 - 142
Опубликована: Май 31, 2025
Язык: Английский
Процитировано
0
Trends in Microbiology, Год журнала: 2023, Номер 32(2), С. 107 - 110
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
7
Опубликована: Янв. 1, 2024
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Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6701 - 6701
Опубликована: Июнь 18, 2024
This study aimed to investigate the gut microbiota composition in children with autism spectrum disorder (ASD) compared neurotypical (NT) children, a focus on identifying potential differences bacteria between these groups. The was analyzed through massive sequencing of region V3-V4 16S RNA gene, utilizing DNA extracted from stool samples participants. Our findings revealed no significant dominant bacterial phyla (Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria, Verrucomicrobiota) ASD and NT However, at genus level, notable disparities were observed abundance Blautia, Prevotella, Clostridium XI, XVIII, all which have been previously associated ASD. Furthermore, sex-based analysis unveiled additional discrepancies composition. Specifically, three genera (Megamonas, Oscilibacter, Acidaminococcus) exhibited variations male female groups both cohorts. Particularly noteworthy exclusive presence Megamonas females Analysis predicted metabolic pathways suggested an enrichment related amine polyamine degradation, as well amino acid degradation group. Conversely, implicated carbohydrate biosynthesis, fermentation found be underrepresented. Despite limitations our study, including relatively small sample size (30 31 children) utilization derived gene rather than metagenome sequencing, contribute growing body evidence suggesting association Future research endeavors should validating larger sizes exploring functional significance microbial Additionally, there is critical need for further investigations elucidate sex their implications pathology treatment.
Язык: Английский
Процитировано
1
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Окт. 18, 2024
Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via
Язык: Английский
Процитировано
1
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 28, 2024
Oligofructose prebiotic fiber supplementation has been reported to mitigate the effects of a high fat/high sucrose diet and reduce knee joint degeneration in male rats. However, few studies investigated development osteoarthritis bone lesions as function sex joints other than knee. This study was aimed at quantifying effect HFS on shoulder health female Sprague-Dawley Rats were randomized into 6 groups: 2 groups fed chow diet: Chow-Male n = 11, Chow-female 12; HFS-Male HFS-Female supplement addition Fiber-Male 6, Fiber- Female 12. After 12 weeks, histologically assessed for OA. Body composition, serum lipid profile, insulin resistance fecal microbiota also assessed. Shoulders rats appear be protected against when exposed diet. Male developed while females did not. Fiber more effective males suggesting that may have sex-specific gut microbiota.
Язык: Английский
Процитировано
1
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Ноя. 26, 2024
Sex differences in colorectal cancer (CRC) has received considerable research attention recently, particularly regarding the influence of sex hormones and intestinal microbiota. Estrogen, at genetic epigenetic levels, directly inhibits CRC cell proliferation by enhancing DNA mismatch repair, regulating miRNAs, blocking cycle, modulating ion channels. However, estradiol's activation GPER promotes oncogene expression. Conversely, androgen contributes to dysregulation progression via nuclear receptors while inducing apoptosis through membrane receptors. Specific gut microorganisms produce genotoxins oncogenic metabolites that damage colonic contribute induction. Regarding tumor microenvironment, estrogen mitigates inflammation, reverses immunosuppression, increases microbiome diversity commensal bacteria abundance, decreases pathogen enrichment. On contrary, disrupts microecology, diminish immunotherapy efficacy, exacerbate inflammation growth. The impact is closely tied their receptor status, elucidating dual roles pathogenesis. This review comprehensively discusses direct indirect effects microbiota on CRC, considering environmental factors such as diet lifestyle propose novel prevention treatment strategies.
Язык: Английский
Процитировано
1
Frontiers in Biomaterials Science, Год журнала: 2024, Номер 3
Опубликована: Фев. 2, 2024
Sex as a biological variable has been recognized for decades to be critical aspect of the drug development process, differences in pharmacology and toxicity female
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер unknown, С. 111200 - 111200
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0