The Transmitter, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
The drug bumetanide had no effect on autism traits in children two clinical trials.
Language: Английский
World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(45), P. 5945 - 5952
Published: Dec. 1, 2023
The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence revealed influence of on other organs such as central nervous system, cardiovascular endocrine-metabolic systems digestive system. study is outlining new broader frontiers every day holds enormous innovation potential for medical pharmaceutical fields. Prevention treatment specific women's diseases involves need deepen function a junction organ where certain positive bacteria can be very beneficial unique dynamic at same time, subject external factors that change it, capable modulating itself different stages woman's life, playing an important role arises from intertwining biological mechanisms between female genital could play key personalized medicine.
Language: Английский
Citations
8
Trends in Microbiology, Journal Year: 2023, Volume and Issue: 32(2), P. 107 - 110
Published: Nov. 10, 2023
Language: Английский
Citations
6
Published: Jan. 1, 2024
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Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6701 - 6701
Published: June 18, 2024
This study aimed to investigate the gut microbiota composition in children with autism spectrum disorder (ASD) compared neurotypical (NT) children, a focus on identifying potential differences bacteria between these groups. The was analyzed through massive sequencing of region V3-V4 16S RNA gene, utilizing DNA extracted from stool samples participants. Our findings revealed no significant dominant bacterial phyla (Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria, Verrucomicrobiota) ASD and NT However, at genus level, notable disparities were observed abundance Blautia, Prevotella, Clostridium XI, XVIII, all which have been previously associated ASD. Furthermore, sex-based analysis unveiled additional discrepancies composition. Specifically, three genera (Megamonas, Oscilibacter, Acidaminococcus) exhibited variations male female groups both cohorts. Particularly noteworthy exclusive presence Megamonas females Analysis predicted metabolic pathways suggested an enrichment related amine polyamine degradation, as well amino acid degradation group. Conversely, implicated carbohydrate biosynthesis, fermentation found be underrepresented. Despite limitations our study, including relatively small sample size (30 31 children) utilization derived gene rather than metagenome sequencing, contribute growing body evidence suggesting association Future research endeavors should validating larger sizes exploring functional significance microbial Additionally, there is critical need for further investigations elucidate sex their implications pathology treatment.
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 18, 2024
Background The gut microbiome has a significant impact on human wellness, contributing to the emergence and progression of range health issues including inflammatory autoimmune conditions, metabolic disorders, cardiovascular problems, psychiatric disorders. Notably, clinical observations have revealed that these illnesses can display differences in incidence presentation between genders. present study aimed evaluate whether composition microbiota is associated with sex-specific elucidate mechanism. Methods 16S-rRNA-sequencing technology, hormone analysis, transplantation, gonadectomy, treatment were employed investigate correlation sex or hormones. Meanwhile, genes proteins involved bile acid signaling pathway analyzed both liver ileum tissues. Results diversity from jejunum feces level hormones serum differed sexes young middle-aged Sprague Dawley (SD) rats. However, no similar phenomenon was found geriatric Interestingly, young, middle-aged, old rats, bacterial Gut replacement also suggested hormones, particularly testosterone (T), influenced mRNA protein (specifically SHP , FXR CYP7A1 ASBT ) exhibited gender-specific differences, T may play role mediating expression this pathway. Conclusion Sex-specific structure are mediated by through pathway, pointing potential targets for disease prevention management techniques indicating levels alter via
Language: Английский
Citations
1
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 26, 2024
Sex differences in colorectal cancer (CRC) has received considerable research attention recently, particularly regarding the influence of sex hormones and intestinal microbiota. Estrogen, at genetic epigenetic levels, directly inhibits CRC cell proliferation by enhancing DNA mismatch repair, regulating miRNAs, blocking cycle, modulating ion channels. However, estradiol's activation GPER promotes oncogene expression. Conversely, androgen contributes to dysregulation progression via nuclear receptors while inducing apoptosis through membrane receptors. Specific gut microorganisms produce genotoxins oncogenic metabolites that damage colonic contribute induction. Regarding tumor microenvironment, estrogen mitigates inflammation, reverses immunosuppression, increases microbiome diversity commensal bacteria abundance, decreases pathogen enrichment. On contrary, disrupts microecology, diminish immunotherapy efficacy, exacerbate inflammation growth. The impact is closely tied their receptor status, elucidating dual roles pathogenesis. This review comprehensively discusses direct indirect effects microbiota on CRC, considering environmental factors such as diet lifestyle propose novel prevention treatment strategies.
Language: Английский
Citations
1
Frontiers in Biomaterials Science, Journal Year: 2024, Volume and Issue: 3
Published: Feb. 2, 2024
Sex as a biological variable has been recognized for decades to be critical aspect of the drug development process, differences in pharmacology and toxicity female
Language: Английский
Citations
0
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 27, 2024
Abstract The complex interactions between host genetics and the gut microbiome are well recognized; however, specific impact of gene expression pattern microbial composition on each other remains to be further explored. Here we investigated this interplay within a sizable population 705 hens, employing integrative analyses examine relationships among genetics, mucosal expression, microbiota. Specific taxa exhibited strong adherence genomic variants, particularly in cecum such as Christensenellaceae family with heritability (h 2 ) 0.365. We proposed novel concept regulatability (\({r}_{b}^{2}\)), which was derived from h , quantify cumulative effects given phenotypes. duodenal transcriptome emerged potent influencer taxa, exceptionally higher \({r}_{b}^{2}\) values (0.17 ± 0.01, mean SE) compared (0.02 0.00). Through comparative analysis chickens humans, revealed similar average microbiability (m 0.18 0.20, significant distinctions vs 0.04). Notably, cis (\({h}_{cis}^{2}\)) quantifies genetic variations proximal its while trans (\({h}_{trans}^{2}\)) assesses influence distant variations. Higher \({h}_{trans}^{2}\) \({h}_{cis}^{2}\), greater prevalence trans-regulated genes over cis-regulated ones underscored role loci outside cis-window shaping levels. Furthermore, our exploration into regulation microbiota 18 traits enhanced understanding their regulatory mechanism, CHST14 Lactobacillus salivarius jointly facilitated deposition abdominal fat. This study has host-microbe dynamics, helps devise strategies modulate for improving economic chicken.
Language: Английский
Citations
0
Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2024, Volume and Issue: 52, P. 101281 - 101281
Published: June 21, 2024
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 28, 2024
Oligofructose prebiotic fiber supplementation has been reported to mitigate the effects of a high fat/high sucrose diet and reduce knee joint degeneration in male rats. However, few studies investigated development osteoarthritis bone lesions as function sex joints other than knee. This study was aimed at quantifying effect HFS on shoulder health female Sprague-Dawley Rats were randomized into 6 groups: 2 groups fed chow diet: Chow-Male n = 11, Chow-female 12; HFS-Male HFS-Female supplement addition Fiber-Male 6, Fiber- Female 12. After 12 weeks, histologically assessed for OA. Body composition, serum lipid profile, insulin resistance fecal microbiota also assessed. Shoulders rats appear be protected against when exposed diet. Male developed while females did not. Fiber more effective males suggesting that may have sex-specific gut microbiota.
Language: Английский
Citations
0