Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology DOI Creative Commons
Michael J. Boucher, Sanjita Banerjee,

Meenakshi Joshi

и другие.

Опубликована: Окт. 22, 2024

Cryptococcus neoformans is the most common cause of fungal meningitis and top-ranked W.H.O. priority pathogen. Only distantly related to model fungi, C. also a powerful experimental system for exploring conserved eukaryotic mechanisms lost from specialist yeast lineages. To decipher its biology globally, we constructed 4328 gene deletions measured--with exceptional precision--the fitness each mutant under 141 diverse growth-limiting in vitro conditions during murine infection. We defined functional modules by clustering genes based on their phenotypic signatures. In-depth studies leveraged these data two ways. First, investigated new components key signaling pathways, which revealed animal-like pathways/components not predicted yeasts. Second, identified environmental adaptation repurposed promote mammalian virulence neoformans, lacks known animal reservoir. Our work provides an unprecedented resource deciphering deadly human

Язык: Английский

A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1 DOI
Gang Luo, Jingkai Zhang, Tianxu Wang

и другие.

Cell Host & Microbe, Год журнала: 2024, Номер 32(9), С. 1536 - 1551.e6

Опубликована: Июль 30, 2024

Язык: Английский

Процитировано

3
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation DOI
Camila Figueiredo Pinzan, Clara Valero, Patrícia Alves de Castro

и другие.

Nature Microbiology, Год журнала: 2024, Номер 9(10), С. 2710 - 2726

Опубликована: Авг. 27, 2024

Язык: Английский

Процитировано

3
Evolutionary insights and functional diversity of gasdermin family proteins and homologs in microorganisms DOI Creative Commons
Shule Wang,

Tingbo Ma,

Xiaoyi Xia

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 20, 2024

The gasdermin protein family and its homologs in microorganisms have gained significant attention due to their roles programmed cell death, immune defense, microbial infection. This review summarizes the current research status of proteins, structural features, functional fungi, bacteria, viruses. presents evolutionary parallels between mammalian defense systems, highlighting conserved role proteins regulating death processes immunity. Additionally, characteristics are summarized, shedding light on potential as targets for therapeutic interventions. Future directions this field also discussed provide a roadmap further investigation.

Язык: Английский

Процитировано

1
Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology DOI Creative Commons
Michael J. Boucher, Sanjita Banerjee,

Meenakshi Joshi

и другие.

Опубликована: Окт. 22, 2024

Cryptococcus neoformans is the most common cause of fungal meningitis and top-ranked W.H.O. priority pathogen. Only distantly related to model fungi, C. also a powerful experimental system for exploring conserved eukaryotic mechanisms lost from specialist yeast lineages. To decipher its biology globally, we constructed 4328 gene deletions measured--with exceptional precision--the fitness each mutant under 141 diverse growth-limiting in vitro conditions during murine infection. We defined functional modules by clustering genes based on their phenotypic signatures. In-depth studies leveraged these data two ways. First, investigated new components key signaling pathways, which revealed animal-like pathways/components not predicted yeasts. Second, identified environmental adaptation repurposed promote mammalian virulence neoformans, lacks known animal reservoir. Our work provides an unprecedented resource deciphering deadly human

Язык: Английский

Процитировано

1