Epigenetic Alterations and Microbiota Changes in the Saliva of Individuals With Binge-Eating Spectrum Disorders Compared With Normal Weight Healthy Controls DOI Creative Commons
Francesca Mercante, Afrouz Abbaspour, Mariangela Pucci

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Abstract Background Binge-eating spectrum disorders, including bulimia nervosa (BN) and binge-eating disorder (BED), have psychological, behavioral, physical effects, which present significant challenges for accurate diagnosis treatment. Identifying biomarkers is thus of relevance to improve diagnostic treatment strategies. Methods Saliva collected from female individuals with BED (n = 20), BN 17), normal weight healthy controls (NW-HC) 20) was analyzed assess salivary microbiome, exosomal miRNA expression, DNA methylation dopaminergic system gene components. Results Microbial diversity significantly reduced in groups compared NW-HC. Differential abundance analysis revealed that Bacilli (class-level) were enriched BED, while Lachnospirales (order-level) depleted In total, 79 miRNAs resulted differentially expressed patients controls. Alteration four these (let-7b-5p, mir-15b-5p, mir-429, mir-221-3p) identified via network as potentially relevant psychiatric confirmed be upregulated both Significant hypomethylation at specific CpG sites the DAT1 also observed relative Correlation highlighted associations between microbiota genera, groups. Conclusions Our findings provide new evidence on role epigenetic modifications linked alterations microbial composition BN, opening avenues future research therapeutic interventions eating disorders targeting microbiota.

Язык: Английский

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 23, 2024

Язык: Английский

Процитировано

12
Intestinal Barrier Impairment, Preservation, and Repair: An Update DOI Open Access
Ashraf Al Matar, John Damianos, Kara Jencks

и другие.

Nutrients, Год журнала: 2024, Номер 16(20), С. 3494 - 3494

Опубликована: Окт. 15, 2024

Our objective was to review published studies of the intestinal barrier and permeability, deleterious effects dietary components (particularly fat), impact altered permeability in disease models human diseases, role microbiome epigenomics control function, opportunities restore normal function with interventions products microbiota.

Язык: Английский

Процитировано

9
Epigenetic Regulatory Processes Involved in the Establishment and Maintenance of Skin Homeostasis—The Role of Microbiota DOI Open Access

Kornélia Szabó,

Fanni Balogh,

Dóra Romhányi

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 438 - 438

Опубликована: Янв. 7, 2025

Epigenetic mechanisms are central to the regulation of all biological processes. This manuscript reviews current understanding diverse epigenetic modifications and their role in establishment maintenance normal skin functions. In healthy skin, these allow for precise control gene expression, facilitating dynamic balance between cell proliferation differentiation necessary effective barrier function. Furthermore, as ages, alterations marks can lead impaired regenerative capacity increased susceptibility environmental stressors. The interaction microbiota will also be explored, highlighting how microbial communities influence health by modulating host expression. Future research should focus on development targeted interventions promote development, resilience, longevity, even an ever-changing environment. underscores need integrative approaches study complex regulatory networks.

Язык: Английский

Процитировано

0
Gut Microbes as the Major Drivers of Rheumatoid Arthritis: Our Microbes Are Our Fortune! DOI Creative Commons
Veena Taneja

Microorganisms, Год журнала: 2025, Номер 13(2), С. 255 - 255

Опубликована: Янв. 24, 2025

Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. While certain genes provide strong susceptibility factors, the role of environmental factors becoming increasingly recognized. Among genetic human leukocyte antigen (HLA) genes, encoded within major histocompatibility complex (MHC), have been linked to predisposition RA, while among smoking, infections and diet are contributors. Genetic impact microbial composition in host. Based on dysbiosis observed gut lung microbiome, a mucosal origin RA has suggested. However, proving whether or microbes stronger risk factor difficult. Studies from patients various mouse models, specifically humanized mice expressing HLA class II instrumental defining such as smoking endogenous small intestinal modulating severity. The consensus based most studies support interaction between host onset severity disease. until now, no markers for prognosis treatment efficacy available. Here, severity, potential using commensals immune responses suppress inflammation context discussed.

Язык: Английский

Процитировано

0
Changes in gut microbiota affect DNA methylation levels and development of chicken muscle tissue DOI Creative Commons
Yibin Xu,

Yunpeng Huang,

Shenghua Wei

и другие.

Poultry Science, Год журнала: 2025, Номер 104(3), С. 104869 - 104869

Опубликована: Фев. 6, 2025

The intestinal microbiome is essential in regulating host muscle growth and development. Antibiotic treatment commonly used to model dysbiosis of the microbiota, yet limited research addresses relationship between gut microbes yellow-feathered broilers. In this study, Xinghua chickens were administered broad-spectrum antibiotics for eight weeks induce suppression. We investigated relationships using 16S rRNA sequencing transcriptomic analysis. Results indicated that antibiotic significantly reduced body weight, dressed eviscerated breast leg weight. Microbial diversity richness duodenum, jejunum, ileum, cecum decreased. relative abundances Firmicutes, Actinobacteria, Bacteroidetes declined, while Proteobacteria increased. This microbial imbalance led 298 differentially expressed genes (DEGs) tissue, which 67 down-regulated enriched skeletal development, including MYF6, MYBPC1 METTL21C DEGs primarily involved MAPK signaling pathway, calcium ECM-receptor interaction, actin cytoskeleton regulation, nitrogen metabolism. Correlation analysis showed dysregulation cecal had most substantial effect on Furthermore, DNMT3b mRNA expression lowered overall DNA methylation SAM levels, induced changes impacted study demonstrates microbiota influence thereby associated with

Язык: Английский

Процитировано

0
Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases DOI Open Access

Shanshan Nai,

Ji‐Ying Song, Wenting Su

и другие.

Genes, Год журнала: 2025, Номер 16(2), С. 208 - 208

Опубликована: Фев. 8, 2025

It is widely known that the dysregulation of non-coding RNAs (ncRNAs) and dysbiosis gut microbiome play significant roles in host development progression various diseases. Emerging evidence has highlighted bidirectional interplay between ncRNAs microbiome. This article aims to review current understanding molecular mechanisms underlying crosstalk ncRNAs, especially microRNA (miRNA), context diseases, such as colorectal cancer, inflammatory bowel neurological disorders, obesity, cardiovascular disease. Ultimately, this seeks provide a foundation for exploring potential interactions biomarkers therapeutic targets clinical diagnosis treatment, ncRNA mimics, antisense oligonucleotides, small-molecule compounds, well probiotics, prebiotics, diets.

Язык: Английский

Процитировано

0
Unveiling familial aggregation of nasopharyngeal carcinoma: Insights from oral microbiome dysbiosis DOI Creative Commons
Ying Liao,

Xia‐Ting Tong,

Ting Zhou

и другие.

Cell Reports Medicine, Год журнала: 2025, Номер unknown, С. 101979 - 101979

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Microbioma humano y epigenética: nuevas fronteras en la salud personalizada DOI Creative Commons

Blanca Elena Unaucho Quishpe,

Rosa Natividad Tacuri Chunata,

Norma Lucia Alvarado Grefa

и другие.

South Florida Journal of Development, Год журнала: 2025, Номер 6(2), С. e5007 - e5007

Опубликована: Фев. 24, 2025

En esta investigación se presenta la relación entre el microbioma humano y epigenética, enfocándose en su importancia salud personalizada presencia varias patologías como las crónicas, metabólicas, autoinmunes neurodegenerativas. A partir de revisión estudios recientes, analizan interacciones los microbiomas, tales intestinales piel, alteraciones epigenéticas que afectan procesos fundamentales, regulación del sistema inmunológico, metabólico progreso cognitivo. El objetivo es investigar cómo alteración microbiomas mediante alimentación, probióticos, ejercicio físico varios métodos terapéuticos sofisticados puede influir marcas epigenéticas, ofreciendo posibilidades para intervenciones particulares basándose características individuales. Se toman cuenta casos efecto microbiota primeros 1,000 días vida, conexión eje microbioma-cerebro durante envejecimiento resistencia a antimicrobianos metabólicas. Este método combina instrumentos análisis multiómico tecnologías actuales un entendimiento más detallado biológicas. Por último, artículo propone marco interdisciplinario reinterpreta medicina actual, indicando profundo vínculo con epigenética transformar prevención tratamiento enfermedades desde una perspectiva personalizada.

Процитировано

0
Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure DOI Open Access
Mohammad Reza Hatamnejad,

Lejla Medzikovic,

Ateyeh Dehghanitafti

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2242 - 2242

Опубликована: Март 2, 2025

The effect of the gut microbiota extends beyond their habitant place from gastrointestinal tract to distant organs, including cardiovascular system. Research interest in relationship between heart and has recently been emerging. secretes metabolites, Trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), bile (BAs), indole propionic acid (IPA), hydrogen sulfide (H2S), phenylacetylglutamine (PAGln). In this review, we explore accumulating evidence on role these secreted metabolites pathophysiology ischemic non-ischemic failure (HF) by summarizing current knowledge clinical studies experimental models. Elevated TMAO contributes HF through TGF-ß/Smad signaling-mediated myocardial hypertrophy fibrosis, impairments mitochondrial energy production, DNA methylation pattern change, intracellular calcium transport. Also, high-level can promote via inflammation, histone methylation-mediated vascular platelet hyperactivity, thrombosis, as well cholesterol accumulation activation MAPK signaling. Reduced SCFAs upregulate Egr-1 protein, T-cell infiltration, HDAC 5 6 activities, leading HF, while reactive oxygen species production hyperactivation caveolin-ACE axis result HF. An altered BAs level worsens contractility, opens permeability transition pores inducing apoptosis, enhances accumulation, eventually exacerbating IPA, inhibition nicotinamide N-methyl transferase expression increased nicotinamide, NAD+/NADH, SIRT3 levels, ameliorate HF; meanwhile, H2S suppressing Nox4 ROS stimulating PI3K/AKT pathway also protect against Furthermore, PAGln affect sarcomere shortening ability myocyte contraction. This emerging field research new avenues for therapies restoring dietary interventions, prebiotics, probiotics, or fecal transplantation such normalizing circulating levels TMAO, SCFA, BAs, H2S, PAGln.

Язык: Английский

Процитировано

0
Pharmacogenomic and Pharmacomicrobiomic Aspects of Drugs of Abuse DOI Open Access
Alejandro Borrego-Ruiz, Juan J. Borrego

Genes, Год журнала: 2025, Номер 16(4), С. 403 - 403

Опубликована: Март 30, 2025

Background/Objectives: This review examines the role of pharmacogenomics in individual responses to pharmacotherapy various drugs abuse, including alcohol, cocaine, and opioids, identify genetic variants that contribute variability substance use disorder treatment outcomes. In addition, it explores pharmacomicrobiomic aspects use, highlighting impact gut microbiome on bioavailability, drug metabolism, pharmacodynamics, pharmacokinetics. Results: Research pharmacogenetics has identified several promising may existing pharmacotherapies for addiction. However, interpretation these findings remains limited. It is estimated factors account 20–95% responses. Therefore, alone cannot fully explain differences responses, such as diversity also play a significant role. Drug microbial biotransformation produced by exoenzymes convert low molecular weight organic compounds into analogous oxidation, reduction, hydrolysis, condensation, isomerization, unsaturation, or introduction heteroatoms. Despite advances pharmacomicrobiomics, challenges persist lack standardized methodologies, inter-individual variability, limited understanding mechanisms, need large-scale validation studies develop microbiota-based biomarkers clinical use. Conclusions: Progress disorders provided biological insights pharmacological needs associated with common drug-metabolizing enzymes. The its metabolites pivotal stages addiction seeking, reward, biotransformation. integrating pharmacomicrobiomics will form crucial foundation precision personalized medicine.

Язык: Английский

Процитировано

0