Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 179 - 179
Опубликована: Янв. 13, 2025
In
the
current
era,
malnutrition
is
seen
as
both
undernutrition
and
overweight
obesity;
conditions
are
caused
by
nutrient
deficiency
or
excess
improper
use
imbalance
in
intake
of
macro
micronutrients.
Recent
evidence
suggests
that
alters
intestinal
microbiota,
known
dysbiosis.
Secretory
immunoglobulin
A
(sIgA)
plays
an
important
role
maintaining
increasing
beneficial
microbiota
populations
protecting
against
pathogenic
species.
Depletion
bacterial
throughout
life
also
conditioned
malnutrition.
This
review
aims
to
synthesize
establishes
interrelationship
between
diet,
malnutrition,
changes
flora,
sIgA
levels.
Targeted
nutritional
therapies
combined
with
prebiotic,
probiotic,
postbiotic
administration
can
restore
immune
response
intestine
host’s
homeostasis.
Язык: Английский
Dysbiosis and extraintestinal cancers
Rui He,
Ping-Qian Qi,
Lin-Zhen Shu
и другие.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2025,
Номер
44(1)
Опубликована: Фев. 7, 2025
Abstract
The
gut
microbiota
plays
a
crucial
role
in
safeguarding
host
health
and
driving
the
progression
of
intestinal
diseases.
Despite
recent
advances
remarkable
correlation
between
dysbiosis
extraintestinal
cancers,
underlying
mechanisms
are
yet
to
be
fully
elucidated.
Pathogenic
microbiota,
along
with
their
metabolites,
can
undermine
integrity
barrier
through
inflammatory
or
metabolic
pathways,
leading
increased
permeability
translocation
pathogens.
dissemination
pathogens
circulation
may
contribute
establishment
an
immune-suppressive
environment
that
promotes
carcinogenesis
organs
either
directly
indirectly.
oncogenic
cascade
always
engages
disruption
hormonal
regulation
responses,
induction
genomic
instability
mutations,
dysregulation
adult
stem
cell
proliferation.
This
review
aims
comprehensively
summarize
existing
evidence
points
potential
malignant
transformation
such
as
liver,
breast,
lung,
pancreas.
Additionally,
we
delve
into
limitations
inherent
current
methodologies,
particularly
challenges
associated
differentiating
low
loads
gut-derived
microbiome
within
tumors
from
sample
contamination
symbiotic
microorganisms.
Although
still
controversial,
understanding
contribution
translocated
metabolites
pathological
continuum
chronic
inflammation
could
offer
novel
foundation
for
development
targeted
therapeutics.
Язык: Английский
Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 28, 2025
Introduction
The
global
health
challenge
of
ulcerative
colitis
(UC)
has
been
classified
by
the
WHO
as
a
modern
refractory
disease,
commonly
referred
to
green
cancer,
with
limited
treatment
options
still
available,
highlighting
urgent
need
for
development
new
therapeutic
strategies.
Recent
pharmacological
research
shown
that
traditional
Chinese
medicine
saussurea
costus
(SC)
possesses
beneficial
antibacterial
and
anti-inflammatory
properties.
Nevertheless,
its
underlying
mechanism
remains
elusive.
Methods
Firstly,
we
identified
main
active
components
SC
through
UHPLC-QTOF-MS
analysis.
Subsequently,
UC
mice
were
induced
using
DSS
administered
different
doses
evaluate
efficacy.
Additionally,
impact
on
repair
intestinal
mucosal
barrier
was
evaluated
immunofluorescence
western
blot.
Furthermore,
16s
rRNA
gene
sequencing
conducted
elucidate
contribution
gut
microbiota
pathogenesis.
Results
primary
include
Proline,
Phenylalanine,
Isoleucine,
Lucidenic
acid
M,
Pyroglutamic
acid.
efficacy
concurrently
assessed,
revealing
potential
ameliorate
histological
injury
in
mice.
found
decrease
levels
TNF-α,
IL-1β,
IL-8,
IL-18
while
promoting
expression
IL-10
IL-22.
Similarly,
also
ZO-1
Occludin
reversed
In
addition,
analysis
16S
indicated
reduced
harmful
bacterial
populations,
such
Proteobacteria
,
simultaneously
enhancing
bacteria
like
Lactobacillus
thereby
contributing
improvement
pathology.
Conclusion
This
study
highlights
managing
ability
attenuate
inflammatory
responses,
restore
functionality,
modulate
composition,
which
findings
offer
insights
into
strategies
advancing
treatment.
Язык: Английский
The Expanding Role of Probiotics in Human Health
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1116 - 1116
Опубликована: Март 24, 2025
Since
the
1990s,
it
has
been
widely
documented
that
probiotics,
either
alone
or
in
combination
with
prebiotic
supplements,
play
a
vital
role
host
health
and
disease
management
[...].
Язык: Английский
Intestinal Microbiota Modulation by Fecal Microbiota Transplantation in Nonalcoholic Fatty Liver Disease
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 779 - 779
Опубликована: Март 23, 2025
Numerous
factors
are
involved
in
the
pathogenesis
of
nonalcoholic
fatty
liver
disease
(NAFLD),
which
responsible
for
its
development
and
progression
as
an
independent
entity,
but
also
thanks
to
their
simultaneous
action.
This
is
explained
by
hypothesis
multiple
parallel
hits.
These
insulin
resistance,
lipid
metabolism
alteration,
oxidative
stress,
endoplasmic
reticulum
inflammatory
cytokine
liberation,
gut
microbiota
dysbiosis
or
gut–liver
axis
activation.
a
systematic
review
has
aim
show
connection
between
intestinal
role
disbalance
NAFLD.
The
made
from
wide
spectrum
microorganisms
that
systemic
impact
on
human
health,
with
well-documented
digestion,
energy
metabolism,
stimulation
immune
system,
synthesis
essential
nutrients,
etc.
It
been
shown
associated
all
three
stages
chronic
disease.
Thus,
modulation
attracted
research
interest
novel
therapeutic
approach
management
NAFLD
patients.
modification
can
be
achieved
substantial
diet
application
probiotics
prebiotics,
while
most
radical
effects
observed
fecal
transplantation
(FMT).
Given
results
FMT
context
metabolic
syndrome
(MetS)
animal
models
scarce
pilot
studies
humans,
seems
promising
treatment
option
could
reverse
thereby
influence
course
Язык: Английский
Lentinula edodes as a Source of Bioactive Compounds with Therapeutical Potential in Intestinal Inflammation and Colorectal Cancer
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3320 - 3320
Опубликована: Апрель 2, 2025
Inflammatory
bowel
disease
(IBD),
including
Crohn's
(CD)
and
ulcerative
colitis
(UC),
is
a
rising
global
health
issue.
Chronic
intestinal
inflammation
an
important
risk
factor
for
colorectal
cancer
(CRC).
Despite
significant
progress
in
IBD
CRC
treatment,
numerous
patients
remain
resistant
to
standard
pharmacotherapy
or
experience
severe
side
effects
that
prevent
them
from
continuing
treatment.
There
evidence
suggesting
bioactive
substances
Lentinula
edodes
have
immunomodulatory
anticancer
properties.
This
fungus
currently
classified
as
functional
food,
considering
its
beneficial
on
human
special
nutritional
value.
Studies
conducted
vitro
animal
models
demonstrated
L.
compounds,
particular
glucans,
anti-inflammatory
antioxidant
effects,
induce
apoptosis
of
cells,
reduce
tumor
angiogenesis,
restore
gut
microbiome
heterogeneity
improve
barrier
dysfunction.
Moreover,
clinical
trials
confirmed
these
compounds
combined
with
chemotherapy
effect
improving
the
prognosis
patients.
In
addition,
glucans
increase
microbial
diversity
enhance
interferon
(IFN)-γ
production
by
immune
cells.
Future
studies
must
be
focused
understanding
pathways
mechanisms
associated
observed
effects.
both
randomized
long-term
follow-up
are
needed
confirm
their
effectiveness
treatment
CRC.
Язык: Английский
Gut Microbiota in Heart Failure—The Role of Inflammation
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 911 - 911
Опубликована: Апрель 9, 2025
Heart
failure
(HF)
has
become
an
immense
health
concern
affecting
almost
1–2%
of
the
population
globally.
It
is
a
complex
syndrome
characterized
by
activation
sympathetic
nervous
system
and
Renin–Angiotensin–Aldosterone
(RAAS)
axis
as
well
endothelial
dysfunction,
oxidative
stress,
inflammation.
The
recent
literature
points
towards
interaction
between
intestinal
flora
heart,
also
called
gut–heart
axis.
human
gastrointestinal
tract
naturally
inhabited
various
microbes,
which
are
distinct
for
each
patient,
regulating
functions
many
organs.
Alterations
gut
microbiome,
process
dysbiosis,
may
result
in
systemic
diseases
have
been
associated
with
heart
through
inflammatory
autoimmune
mechanisms.
disorder
permeability
favors
translocation
microbes
metabolites
capable
inducing
inflammation,
thus
further
contributing
to
deterioration
normal
cardiac
function.
Besides
diet
modifications
exercise
training,
studies
revealed
possible
microbiota
targeted
treatments
managing
failure.
aim
this
review
demonstrate
impact
environment
induced
microbiome
its
on
elucidation
these
novel
therapeutic
approaches.
Язык: Английский
Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources
Foods,
Год журнала:
2024,
Номер
14(1), С. 46 - 46
Опубликована: Дек. 27, 2024
Polyunsaturated
fatty
acids
(PUFAs)
are
vital
dietary
elements
that
play
a
significant
role
in
human
nutrition.
They
highly
regarded
for
their
positive
contributions
to
overall
health
and
well-being.
Beyond
the
fact
they
provide
substantial
supply
of
energy
body
(a
saturated
fats
can
also
perform),
these
unsaturated
and,
especially,
essential
ones
involved
cell
membrane
structure,
blood
pressure
regulation,
coagulation;
participate
proper
functioning
immune
system
assimilation
fat-soluble
vitamins;
influence
synthesis
pro-
anti-inflammatory
substances;
protect
cardiovascular
system.
Modern
diets
like
Western
diet
American
rich
found
especially
fast
food
products,
sweets,
processed
foods,
has
led
an
increase
prevalence
metabolic
diseases
worldwide
(obesity,
type
II
diabetes,
gout,
disease).
Nutritionists
have
drawn
attention
moderate
consumption
need
intake
detriment
ones.
This
paper
examines
biochemical
roles
polyunsaturated
fats,
particularly
acids,
contrasts
benefits
with
detrimental
effects
fat
overconsumption.
Furthermore,
it
highlights
necessity
shifts
towards
increased
PUFA
mitigate
global
burden
diet-related
issues.
The
co-occurrence
PUFAs
polyphenols
plant-based
foods
sophistication
nature’s
design.
These
bioactive
compounds
not
randomly
distributed
but
present
humans
consumed
together
historically.
From
traditional
Mediterranean,
which
pairs
olive
oil
(PUFAs
polyphenols)
vegetables
legumes,
Asian
cuisines
combining
sesame
seeds
turmeric,
cultural
practices
long
harnessed
this
natural
synergy.
Язык: Английский
High-resolution analysis of the treated coeliac disease microbiome reveals increased inter-individual variability
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 11, 2024
Abstract
Background
Coeliac
disease
(CeD)
is
an
immune-mediated
disorder
primarily
affecting
the
small
intestine,
characterised
by
inflammatory
immune
reaction
to
dietary
gluten.
CeD
onset
results
from
a
multifaceted
interplay
of
genetic
and
environmental
factors.
While
recent
data
show
that
alterations
in
gut
microbiome
composition
could
play
important
role,
many
current
studies
are
constrained
sample
sizes
limited
resolution.
Methods
To
address
these
limitations,
we
analysed
faecal
microbiota
two
Dutch
cohorts,
CeDNN
(128
treated
patients
(tCeD),
106
controls)
Lifelines
Microbiome
Project
(24
self-reported
tCeD,
654
controls),
using
shotgun
metagenomic
sequencing.
Self-reported
IBS
(570
cases,
1710
IBD
(93
465
were
used
as
comparative
conditions
gastrointestinal
tract.
Interindividual
variation
within
case
control
groups
was
calculated
at
whole
strain
level.
Finally,
species-specific
gene
repertoires
tCeD
controls.
Results
Within-individual
diversity
decreased
with
but
not
patients.
Each
condition
displayed
unique
microbial
pattern
and,
addition
confirming
previously
reported
associations,
identify
increase
levels
Clostridium
sp.
CAG:253
,
Roseburia
hominis
Eggerthella
lenta
amongst
others.
We
further
observed
changes
can
partially
be
explained
gluten-free
diet
adherence.
also
observe
increased
interindividual
among
higher
bacterial
mutation
frequency
contributes
In
addition,
immotile
European
subspecies
Eubacterium
rectale
which
has
distinct
carbohydrate
metabolism
potential,
nearly
absent
Conclusion
Our
study
sheds
light
on
complex
between
CeD,
revealing
strain-level
These
findings
expand
our
understanding
microbiome’s
role
intestinal
health
disease.
Highlights
This
largest
collection
coeliac
assembled
date,
providing
insights
into
down
Compared
controls,
(tCeD)
adhering
novel
associations.
have
less
uniform
than
Bacteria
display
compared
Hallmarks
patients,
implying
selection
Язык: Английский