Epigenetic Alterations and Microbiota Changes in the Saliva of Individuals With Binge-Eating Spectrum Disorders Compared With Normal Weight Healthy Controls DOI Creative Commons
Francesca Mercante, Afrouz Abbaspour, Mariangela Pucci

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Abstract Background Binge-eating spectrum disorders, including bulimia nervosa (BN) and binge-eating disorder (BED), have psychological, behavioral, physical effects, which present significant challenges for accurate diagnosis treatment. Identifying biomarkers is thus of relevance to improve diagnostic treatment strategies. Methods Saliva collected from female individuals with BED (n = 20), BN 17), normal weight healthy controls (NW-HC) 20) was analyzed assess salivary microbiome, exosomal miRNA expression, DNA methylation dopaminergic system gene components. Results Microbial diversity significantly reduced in groups compared NW-HC. Differential abundance analysis revealed that Bacilli (class-level) were enriched BED, while Lachnospirales (order-level) depleted In total, 79 miRNAs resulted differentially expressed patients controls. Alteration four these (let-7b-5p, mir-15b-5p, mir-429, mir-221-3p) identified via network as potentially relevant psychiatric confirmed be upregulated both Significant hypomethylation at specific CpG sites the DAT1 also observed relative Correlation highlighted associations between microbiota genera, groups. Conclusions Our findings provide new evidence on role epigenetic modifications linked alterations microbial composition BN, opening avenues future research therapeutic interventions eating disorders targeting microbiota.

Язык: Английский

Conversation between skin microbiota and the host: from early life to adulthood DOI Creative Commons
Jimin Cha, Tae‐Gyun Kim, Ji-Hwan Ryu

и другие.

Experimental & Molecular Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract Host life is inextricably linked to commensal microbiota, which play a crucial role in maintaining homeostasis and immune activation. A diverse array of microbiota on the skin interacts with host, influencing physiology various ways. Early-life exposure has long-lasting effects, disruption epidermal barrier or transient these microorganisms can lead dysbiosis inflammation. Several have potential function as either commensals pathogens, both being influenced by pathogenesis inflammatory diseases. Here we explore impact host elucidate interactions between systems. deeper understanding may open new avenues for developing effective strategies address

Язык: Английский

Процитировано

0
The role of the gut microbiota in the onset and progression of heart failure: insights into epigenetic mechanisms and aging DOI Creative Commons
Giulia Matacchione, Francesco Piacenza,

Lorenzo Pimpini

и другие.

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Ноя. 29, 2024

The gut microbiota (GM) plays a critical role in regulating human physiology, with dysbiosis linked to various diseases, including heart failure (HF). HF is complex syndrome significant global health impact, as its incidence doubles each decade of life, and prevalence peaks individuals over 80 years. A bidirectional interaction exists between GM HF, where alterations can worsen the disease's progression. "gut hypothesis HF" suggests that HF-induced changes, such reduced intestinal perfusion altered motility, negatively impact composition, leading increased permeability, release GM-derived metabolites into bloodstream, systemic inflammation. This process creates vicious cycle further deteriorates function. metabolites, trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), secondary bile (BAs), influence gene expression through epigenetic mechanisms, DNA methylation histone modifications. These changes may play crucial mediating effects dysbiotic microbial linking them cardiac contributing progression HF. particularly relevant older individuals, aging itself has been associated both cumulative alterations, intensifying interplay GM, increasing risk elderly. Despite growing body evidence, modifications, remains poorly understood. dynamic nature epigenetics shaped by factors age, diet, lifestyle, presents challenges elucidating precise mechanisms underlying this relationship. Future research should prioritize innovative approaches overcome these limitations. By identifying specific metabolite-induced modifications modulating composition function novel personalized therapeutic strategies for prevention and/or treatment be developed. Moreover, targeted focusing specifically on understanding intricate connections epigenetics, during aging.

Язык: Английский

Процитировано

4
Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis DOI
Floor S Baas, Nele Brusselaers, Irıs D. Nagtegaal

и другие.

Cell Host & Microbe, Год журнала: 2024, Номер 32(8), С. 1235 - 1247

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

3
Butyrate-producingFaecalibacterium prausnitziisuppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway DOI Creative Commons
Zhuangzhuang Shi, Min Li, Chen Zhang

и другие.

Gut, Год журнала: 2024, Номер unknown, С. gutjnl - 333530

Опубликована: Дек. 9, 2024

Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes. To characterise gut microbiota feature identify potential probiotics that could ameliorate development of NKTCL. This cross-sectional study employed shotgun metagenomic sequencing to profile two Chinese NKTCL cohorts, validation conducted an independent Korean cohort. Univariable multivariable Cox proportional hazards analyses were applied assess associations between identified marker species patient Tumour-suppressing effects investigated using comprehensive vivo vitro models. In addition, metabolomics, RNA sequencing, chromatin immunoprecipitation Western blot analysis, immunohistochemistry lentiviral-mediated gene knockdown system used elucidate underlying mechanisms. We first unveiled significant dysbiosis patients, prominently marked by notable reduction Faecalibacterium prausnitzii which correlated strongly shorter survival among patients. Subsequently, we substantiated antitumour properties F. mouse Furthermore, culture supernatant demonstrated efficacy inhibiting cell growth. Metabolomics analysis revealed butyrate as critical metabolite these tumour-suppressing effects, validated three human lines multiple tumour-bearing Mechanistically, suppressed activation Janus kinase-signal transducer activator transcription pathway through enhancing histone acetylation, promoting expression suppressor cytokine signalling 1. These findings uncover distinctive provide novel perspective on leveraging therapeutic this malignancy.

Язык: Английский

Процитировано

3
Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon ( Salmo salar ) DOI Creative Commons

Aikaterini Katirtzoglou,

Søren B. Hansen, Harald Sveier

и другие.

Epigenetics, Год журнала: 2024, Номер 19(1)

Опубликована: Авг. 16, 2024

The canonical view of DNA methylation, a pivotal epigenetic regulation mechanism in eukaryotes, dictates its role as suppressor gene activity, particularly within promoter regions. However, this is being challenged it becoming increasingly evident that the connection between methylation and expression varies depending on genomic location therefore more complex than initially thought. We examined levels gut epithelium Atlantic salmon (

Язык: Английский

Процитировано

1
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine DOI Creative Commons

W L Hu,

Shuoling Chen,

Xianghui Zou

и другие.

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions each system in living organisms. In oral cavity, interaction between host microbiome forms microbial homeostasis. Physiological bone remodeling renewal can occur under maintenance The imbalance homeostasis key mechanism leading to occurrence systemic bone-related diseases. Considering importance homeostasis, it still lacks complete understanding relationship microbiome, periodontal disease

Язык: Английский

Процитировано

1
Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome DOI Open Access
Alejandro Borrego-Ruiz, Juan J. Borrego

Genes, Год журнала: 2024, Номер 15(12), С. 1599 - 1599

Опубликована: Дек. 14, 2024

Background/Objectives: Aging is a natural physiological process involving biological and genetic pathways. Growing evidence suggests that alterations in the epigenome during aging result transcriptional changes, which play significant role onset of age-related diseases, including cancer, cardiovascular disease, diabetes, neurodegenerative disorders. For this reason, epigenetic diseases have been reviewed, major extrinsic factors influencing these identified. In addition, gut microbiome its metabolites as modifiers has addressed. Results: Long-term exposure to such air pollution, diet, drug use, environmental chemicals, microbial infections, physical activity, radiation, stress provoke changes host through several endocrine immune pathways, potentially accelerating process. Diverse studies reported plays critical regulating brain cell functions DNA methylation histone modifications. The interaction between genes serves source adaptive variation, contributing phenotypic plasticity. However, molecular mechanisms signaling pathways driving are still not fully understood. Conclusions: Extrinsic potential inducers alterations, may important implications for longevity. an effector gene expression modifications, while bidirectional interactions with underexplored roles non-bacterial microorganisms fungi viruses highlight need further research.

Язык: Английский

Процитировано

1
Epigenetic Alterations and Microbiota Changes in the Saliva of Individuals With Binge-Eating Spectrum Disorders Compared With Normal Weight Healthy Controls DOI Creative Commons
Francesca Mercante, Afrouz Abbaspour, Mariangela Pucci

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Abstract Background Binge-eating spectrum disorders, including bulimia nervosa (BN) and binge-eating disorder (BED), have psychological, behavioral, physical effects, which present significant challenges for accurate diagnosis treatment. Identifying biomarkers is thus of relevance to improve diagnostic treatment strategies. Methods Saliva collected from female individuals with BED (n = 20), BN 17), normal weight healthy controls (NW-HC) 20) was analyzed assess salivary microbiome, exosomal miRNA expression, DNA methylation dopaminergic system gene components. Results Microbial diversity significantly reduced in groups compared NW-HC. Differential abundance analysis revealed that Bacilli (class-level) were enriched BED, while Lachnospirales (order-level) depleted In total, 79 miRNAs resulted differentially expressed patients controls. Alteration four these (let-7b-5p, mir-15b-5p, mir-429, mir-221-3p) identified via network as potentially relevant psychiatric confirmed be upregulated both Significant hypomethylation at specific CpG sites the DAT1 also observed relative Correlation highlighted associations between microbiota genera, groups. Conclusions Our findings provide new evidence on role epigenetic modifications linked alterations microbial composition BN, opening avenues future research therapeutic interventions eating disorders targeting microbiota.

Язык: Английский

Процитировано

0