Pubertal development and pain incidence and characteristics in children: a 1-year prospective cohort study of a national sample

Pain, Год журнала: 2023, Номер 164(12), С. 2725 - 2736

Опубликована: Июнь 21, 2023

Sex differences in pain become apparent during puberty. However, the influence of key pubertal characteristics and hormones on is largely unknown. We examined prospective associations between self-reported hormone-indicated incidence severity 10- to 11-year-old pain-free youth Adolescent Brain Cognitive Development (ABCD) Study over 1 year. Puberty was measured at baseline follow-up with self-report (Pubertal Scale [PDS]) hormonal assessment (salivary dehydroepiandrosterone [DHEA], testosterone, estradiol). Pain status (yes/no), intensity, interference (0-10 numerical rating scale) past month were follow-up. Pubertal maturity, progression, asynchrony relation onset through confounder-adjusted generalized estimating equations modified Poisson linear mixed regression models. Among 6631 baseline, 1-year incident 30.7%. In both sexes, higher PDS scores associated greater risk (relative [RR] = 1.10 1.27, P s < 0.01). boys, item variance (RR 1.11, 95% CI, 1.03-1.20) (beta 0.40, 0.03-0.76); overall gonadal intensity ( 0.05). Associations seen boys only, each 10-fold testosterone levels a 40% lower (95% -55% -22%) 1.30-point -2.12 -0.48) DHEA 0.020). Relationships development peripubertal adolescents are sex specific puberty measurement warrant further investigation.

Язык: Английский

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Pain Catastrophizing Moderates the Relationship Between Pain Sensitivity and Clinical Pain in Adolescents With Functional Abdominal Pain

Journal of Pain, Год журнала: 2024, Номер 25(9), С. 104549 - 104549

Опубликована: Апрель 23, 2024

Язык: Английский

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Influence of chronotype on pain incidence during early adolescence

Pain, Год журнала: 2024, Номер 165(11), С. 2595 - 2605

Опубликована: Май 28, 2024

Abstract During adolescence major shifts in sleep and circadian systems occur with a notable phase delay. Yet, the influence on pain during early is largely unknown. Using 2 years of data from Adolescent Brain Cognitive Development study, we investigated impact chronotype incidence, moderate-to-severe pain, multiregion 1 year later U.S. adolescents. Based Munich ChronoType Questionnaire, was calculated as midpoint between onset offset free days, corrected for debt over week. Adolescents reported presence past month, if present, rated intensity (0-10 numerical rating scale; ≥ 4 defined pain) body site locations (Collaborative Health Outcomes Information Registry Body Map; ≥2 regions pain). Three-level random intercept logistic regression models were specified each outcome, adjusting baseline sociodemographic developmental characteristics. Among 5991 initially pain-free adolescents (mean age 12.0 years, SD 0.7), mean 3:59 am (SD 97 minutes), 1-year incidence 24.4%, 15.2%, 13.5%, respectively. Each hour at associated higher odds developing any (odds ratio [OR] = 1.06, 95% confidence interval [CI] 1.01, 1.11), (OR 1.10, CI 1.05-1.17), 1.08, 1.02-1.14) follow-up. In this diverse adolescent sample, predicted new-onset pain.

Язык: Английский

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Sex differences in comorbid pain and opioid use disorder: A scoping review

British Journal of Clinical Pharmacology, Год журнала: 2024, Номер 90(12), С. 3067 - 3083

Опубликована: Авг. 21, 2024

Opioid use disorder (OUD) and chronic pain are commonly co‐occurring disorders which can exacerbate each other. Sex/gender differences have been shown in aspects of the clinical course biological underpinnings both OUD pain. The purpose this scoping review is to summarize literature has addressed sex/gender relation confluence This focused on peer‐reviewed journal articles with human subjects addressing (a) opioid misuse, or (OUD), (b) persistent (c) and/or Of 146 papers identified by search strategy, 30 met criteria for inclusion. Charting a priori themes pain, misuse/OUD sample, predictor outcome variables, key study findings. majority research was cross‐sectional nature, treatment effects were largely included as post‐hoc analyses. Together, results early work align higher prevalence men/males women/females, while adding critical information respect potential development their co‐occurrence across range psychosocial factors. Findings underline importance considering sex gender intersection

Язык: Английский

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Co-creation in healthcare and research to improve service delivery for young people with chronic pain

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 12, 2024

The process of co-creation can enable more effective, agile and integrated healthcare solutions achieving outcomes that effectively translate to delivery. Collaborative knowledge generation is particularly important in fields such as pediatric chronic pain where there a complex interplay between biological, social, environmental, emotional, familial school factors. initiative described here was designed amplify the voices youth with their families variety key stakeholders generate novel approaches management setting South Australian Pediatric Chronic Pain Service.

Язык: Английский

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Pain and development: interacting phenomena

Pain, Год журнала: 2024, Номер 165(11S), С. S82 - S91

Опубликована: Окт. 14, 2024

Abstract For decades, clinicians and researchers have observed bidirectional relationships between child development the pain experience in childhood. Pain childhood is an inherently developmental phenomenon, embedded iterative, time-dependent process that reflects individual biological, behavioral, social, psychological, environmental characteristics unfold across early life span. Childhood can wide ranging effects on brain ways contribute—for better worse—to emotional, cognitive well-being into adulthood. Atypical trajectories of context disorders such as autism, cerebral palsy, ADHD, mood/anxiety also contribute to unique experiences. In this paper, will be considered a determinant development, conversely key child's experience. We discuss how intersectional identities (eg, gender, race, socioeconomic status) associated structural, systemic, physical environments influence relationship pain. Finally, we identify what might needed think “developmentally” extend from “bench side” lab “curb community, integrating perspective research clinical practice achieve health accessibility equity care for all children spectrum.

Язык: Английский

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Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 9, 2024

Abstract Background Functional abdominal pain disorders (FAPD) are the most common chronic conditions of childhood and made worse by co-occurring anxiety. Our research team found that Aim to Decrease Pain Anxiety Treatment (ADAPT), a six-session coping skills program using cognitive behavioral therapy strategies, was effective in improving pain-related symptoms anxiety compared standard care. In follow-up, this current randomized clinical trial (RCT) aims test potential neural mechanisms underlying effect ADAPT. Specifically, two-arm RCT will explore changes amygdalar functional connectivity (primary outcome) following ADAPT protocol during water loading symptom provocation task (WL-SPT). Secondary (e.g., regional cerebral blood flow via pulsed arterial spin labeling MRI) exploratory association between symptoms) outcomes also be investigated. Methods We include patients ages 11 16 years presenting outpatient pediatric gastroenterology care at midwestern children’s hospital with diagnosis FAPD plus evidence based on validated screening tool (the Generalized Disorder-7 [GAD-7] measure). Eligible participants undergo baseline neuroimaging involving WL-SPT, assessment self-reported pain, anxiety, additional symptoms, prior being six-week remotely delivered medical or alone (waitlist). Thereafter, subjects complete post visit similar nature their first visit. Conclusions This small scale increase understanding response ClinicalTrials.gov registration: NCT03518216

Язык: Английский

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Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0299170 - e0299170

Опубликована: Март 18, 2024

Background Functional abdominal pain disorders (FAPD) are the most common chronic conditions of childhood and made worse by co-occurring anxiety. Our research team found that Aim to Decrease Pain Anxiety Treatment (ADAPT), a six-session coping skills program using cognitive behavioral therapy strategies, was effective in improving pain-related symptoms anxiety compared standard care. In follow-up, this current randomized clinical trial (RCT) aims test potential neural mechanisms underlying effect ADAPT. Specifically, two-arm RCT will explore changes amygdalar functional connectivity (primary outcome) following ADAPT protocol during water loading symptom provocation task (WL-SPT). Secondary (e.g., regional cerebral blood flow via pulsed arterial spin labeling MRI) exploratory association between symptoms) outcomes also be investigated. Methods We include patients ages 11 16 years presenting outpatient pediatric gastroenterology care at midwestern children’s hospital with diagnosis FAPD plus evidence based on validated screening tool (the Generalized Disorder-7 [GAD-7] measure). Eligible participants undergo baseline neuroimaging involving WL-SPT, assessment self-reported pain, anxiety, additional symptoms, prior being six-week remotely delivered medical or alone (waitlist). Thereafter, subjects complete post visit similar nature their first visit. Conclusions This small scale increase understanding response Trial registration ClinicalTrials.gov registration: NCT03518216 .

Язык: Английский

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Reference Values for the Adolescent Post Version of the Postconcussion Symptom Inventory from the German General Population

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Purpose The present study aims at providing reference values from the general pediatric population for German version of 21-item self-report post Postconcussion Symptom Inventory adolescents aged 13–17 years (PCSI-SR13) following traumatic brain injury (pTBI). Methods A total N = 950 completed an adapted PCSI-SR13. Prior to establishing using percentiles, psychometric properties (i.e., reliability and factorial validity) regression analyses were examined identify factors contributing PCSI-SR13 scores. In addition, construct assessment in sample was compared that pTBI (N 234) measurement invariance direct comparisons score levels. Results results indicate good (Cronbach’s α McDonald’s ω 0.97 each). four-factor structure covering physical, emotional, cognitive, fatigue symptom groups could be replicated with χ2(183) 995.96, p < 0.001, χ2/df 5.44, CFI 0.99, TLI 0.98, RMSEA[90% CI] 0.068[0.064, 0.073], SRMR 0.03. With minor restrictions, symptoms comparable between TBI samples. Participants reported a significantly higher burden than those sample. Reference provided without further stratification. Conclusions For PCSI-SR13, are now available drawing conclusions about clinical relevance symptoms, while considering prevalence history pTBI. Trial registration is retrospectively registered Clinical Trials Register International Registry Platform (ID DRKS00032854).

Язык: Английский

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Comparison of EQ-5D-Y-3L Utility Scores Using Nine Country-Specific Value Sets in Chinese Adolescents

PharmacoEconomics, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

Язык: Английский

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