Crossing the blood-brain barrier with nanoparticles

Journal of Controlled Release, Год журнала: 2017, Номер 270, С. 290 - 303

Опубликована: Дек. 19, 2017

Язык: Английский

---

Zebrafish models for translational neuroscience research: from tank to bedside

Trends in Neurosciences, Год журнала: 2014, Номер 37(5), С. 264 - 278

Опубликована: Апрель 9, 2014

Язык: Английский

---

Half a century of amyloids: past, present and future

Chemical Society Reviews, Год журнала: 2020, Номер 49(15), С. 5473 - 5509

Опубликована: Янв. 1, 2020

Amyloid diseases are global epidemics with profound health, social and economic implications yet remain without a cure. This dire situation calls for research into the origin pathological manifestations of amyloidosis to stimulate continued development new therapeutics. In basic science engineering, cross-β architecture has been constant thread underlying structural characteristics functional amyloids, realizing that amyloid structures can be both in nature fuelled innovations artificial whose use today ranges from water purification 3D printing. At conclusion half century since Eanes Glenner's seminal study amyloids humans, this review commemorates occasion by documenting major milestones date, perspectives biology, biophysics, medicine, microbiology, engineering nanotechnology. We also discuss challenges opportunities drive interdisciplinary field moving forward.

Язык: Английский

---

Use of Zebrafish in Drug Discovery Toxicology

Chemical Research in Toxicology, Год журнала: 2019, Номер 33(1), С. 95 - 118

Опубликована: Окт. 18, 2019

Unpredicted human safety events in clinical trials for new drugs are costly terms of health and money. The drug discovery industry attempts to minimize those with diligent preclinical testing. Current standard practices good at preventing toxic compounds from being tested the clinic; however, false negative toxicity results still a reality. Continual improvement must be pursued realm. Higher-quality therapies can brought forward more information about potential toxicities associated mechanisms. zebrafish model is bridge between vitro assays mammalian vivo studies. This powerful its breadth application tractability research. In past two decades, our understanding disease biology has grown significantly owing thousands studies on this tiny vertebrate. Review summarizes challenges strengths model, discusses 3Rs value that it deliver, highlights translatable untranslatable biology, brings together reports recent focusing toxicology.

Язык: Английский

---

Zebrafish Larvae as a Behavioral Model in Neuropharmacology

Biomedicines, Год журнала: 2019, Номер 7(1), С. 23 - 23

Опубликована: Март 26, 2019

Zebrafish larvae show a clear and distinct pattern of swimming in response to light dark conditions, following the development swim bladder at 4 days post fertilization. This behavior is increasingly employed screening neuroactive drugs. The recent emergence high-throughput techniques for automatic tracking zebrafish has further allowed an objective efficient way finding subtle behavioral changes that could go unnoticed during manual observations. review highlights use as model compounds. We describe, brief, repertoire larvae. Then, we focus on utilization light-dark locomotion test identifying

Язык: Английский

---

Advanced Morphological — Behavioral Test Platform Reveals Neurodevelopmental Defects in Embryonic Zebrafish Exposed to Comprehensive Suite of Halogenated and Organophosphate Flame Retardants

Toxicological Sciences, Год журнала: 2015, Номер 145(1), С. 177 - 195

Опубликована: Фев. 23, 2015

The increased use of flammable plastics and electronic devices along with stricter fire safety standards has led to the heavy flame retardant chemicals in many consumer, commercial, industrial products. Although increased, a great deal uncertainty surrounds their some evidence showing toxicity risk human environmental health. Recent efforts have focused on designing high-throughput biological platforms nonmammalian models evaluate prioritize limited hazard information. To complement these efforts, this study used new morphological behavioral testing platform embryonic zebrafish characterize developmental 44 halogenated organophosphate retardants, including several known metabolites. Zebrafish were exposed retardants from 6 120 h post fertilization (hpf) across concentrations spanning 4 orders magnitude (eg, 6.4 nM 64 µM). Flame effects survival development evaluated at 24 hpf, neurobehavioral changes measured using 2 photomotor response (PMR) assays. Compared controls, 93% (41/44) studied elicited adverse among one or more bioassays tested aryl phosphate ester (APE)-based mono-isopropylated triaryl brominated-bisphenol-A analog tetrabromobisphenol-A producing greatest array malformations. Hierarchical clustering showed that APE isopropyl, butyl, cresyl substituents phenyl rings clustered tightly particularly potent. Both PMR assays highly predictive defects supporting as nonlethal means evaluating teratogenicity could allow for additional evaluations long-term delayed older animals. Taken together, presented here indicates neurodevelopment is sensitive currently can be understand potential vulnerabilities

Язык: Английский

---

The future of rodent models in depression research

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(11), С. 686 - 701

Опубликована: Окт. 2, 2019

Язык: Английский

---

Molecular psychiatry of zebrafish

Molecular Psychiatry, Год журнала: 2014, Номер 20(1), С. 2 - 17

Опубликована: Окт. 28, 2014

Язык: Английский

---

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

Experimental Neurology, Год журнала: 2017, Номер 299, С. 157 - 171

Опубликована: Окт. 11, 2017

Язык: Английский

---

Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests

Zebrafish, Год журнала: 2017, Номер 14(3), С. 197 - 208

Опубликована: Май 1, 2017

Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized neuroscience research central nervous system (CNS) drug discovery. Representing the most commonly used models, novel tank test (NTT) focuses on diving response to potentially threatening stimuli, whereas light-dark (LDT) based fish scototaxis (innate preference for dark vs. bright areas). Here, we systematically evaluate utility these two tests, combining meta-analyses published literature with comparative vivo behavioral whole-body endocrine (cortisol) testing. Overall, NTT LDT behaviors demonstrate a generally good cross-test correlation vivo, show that both tests have similar sensitivity anxiety-like states. Finally, evokes higher levels cortisol, likely representing more stressful procedure than LDT. Collectively, our study reappraises studying states zebrafish, emphasizes their developing neurobehavioral research. These findings can help optimize screening procedures by choosing appropriate models testing anxiolytic or anxiogenic drugs.

Язык: Английский

---