Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1393 - 1393
Опубликована: Окт. 31, 2024
Chronic
kidney
disease
(CKD)
represents
a
significant
global
health
challenge,
affecting
millions
of
individuals
and
leading
to
substantial
morbidity
mortality.
This
review
aims
explore
the
epidemiology,
cardiovascular
complications,
management
strategies
associated
with
CKD,
emphasizing
importance
preventing
early
intervention.
CKD
is
primarily
driven
by
conditions
such
as
diabetes
mellitus,
hypertension,
diseases,
which
often
coexist
exacerbate
renal
impairment.
Effective
requires
multifaceted
approach,
including
lifestyle
modifications,
pharmacological
interventions,
regular
monitoring.
Dietary
changes,
sodium
restriction
controlled
intake
phosphorus
potassium,
play
vital
role
in
preserving
function.
Pharmacological
therapies,
particularly
angiotensin-converting
enzyme
(ACE)
inhibitors,
angiotensin
receptor
blockers
(ARBs),
emerging
agents
like
SGLT2
have
shown
efficacy
slowing
progression
improving
patient
outcomes.
Furthermore,
patients
undergoing
dialysis
face
increased
risk,
necessitating
comprehensive
address
both
cardiac
health.
As
landscape
treatment
evolves,
ongoing
research
into
novel
therapeutic
options
personalized
medical
approaches
are
essential.
underscores
urgent
need
for
awareness,
education,
effective
preventive
measures
mitigate
burden
enhance
quality
life
affected
individuals.
Egyptian Liver Journal,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 12, 2024
Abstract
Background
Polyploidization,
a
process
where
cells
acquire
additional
chromosome
sets,
is
unique
characteristic
of
hepatocytes.
This
has
been
increasingly
recognized
as
an
adaptive
mechanism
for
maintaining
liver
function
during
aging,
period
characterized
by
cellular
senescence,
DNA
damage,
and
metabolic
dysregulation.
Purpose
review
explores
the
molecular
mechanisms
underlying
hepatocyte
polyploidization
its
potential
role
in
promoting
resilience
against
aging-related
decline
function.
We
assess
how
polyploid
hepatocytes
contribute
to
genomic
stability,
stress
resistance,
adaptation,
highlighting
their
relevance
aging.
Main
body
Hepatocyte
occurs
through
such
cytokinesis
failure
endoreplication,
leading
binuclear
or
mononuclear
cells.
Polyploid
exhibit
enhanced
repair
capacity,
which
helps
mitigate
accumulation
age-related
damage.
The
increased
gene
dosage
facilitates
better
responses,
particularly
oxidative
genotoxic
insults.
Metabolic
adaptations,
including
xenobiotic
metabolism
lipid
regulation,
further
support
liver’s
ability
maintain
homeostasis
Additionally,
demonstrate
altered
epigenetic
landscapes
proteostasis
mechanisms,
contributing
improved
reduced
susceptibility
senescence.
These
adaptations
collectively
enhance
structural
challenges.
Conclusion
represents
critical
protective
that
safeguard
instability,
dysfunction,
stress.
Understanding
pathways
driving
could
pave
way
novel
therapeutic
strategies
combat
disorders
health
span.
Graphical
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10757 - 10757
Опубликована: Окт. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
The FASEB Journal,
Год журнала:
2024,
Номер
38(16)
Опубликована: Авг. 19, 2024
Abstract
Since
the
12
major
signs
of
aging
were
revealed
in
2023,
people's
interpretation
will
go
further,
which
is
great
significance
for
understanding
occurrence,
development,
and
intervention
process.
As
one
aging,
cellular
senescence
refers
to
process
proliferation
differentiation
ability
cells
decrease
under
stress
stimulation
or
over
time,
often
manifested
as
changes
cell
morphology,
cycle
arrest,
decreased
metabolic
function.
Interferon
(IFN),
a
secreted
ligand
specific
surface
receptors,
can
trigger
transcription
interferon‐stimulated
genes
(ISGs)
play
an
important
role
senescence.
In
addition,
IFN
serves
component
SASP,
activation
signaling
pathway
has
been
shown
contribute
apoptosis
It
expected
delay
by
linking
with
studying
effects
on
its
mechanism.
This
article
provides
review
research
relationship
between
consulting
relevant
literature.
ABSTRACT
The
senescence
of
leafy
vegetables
is
inherent
and
general
after
harvest.
DNA
methylation
affects
the
process
plant
leaves.
Limited
studies
have
explored
impact
exogenous
inhibitors
on
postharvest
mechanisms
their
effects
transcriptome
metabolome
during
storage.
In
this
study,
pak
choi
was
immersed
in
100
mg
L
−1
5‐azacytidine
(AZ)
(an
inhibitor
methyltransferase)
solutions,
indicated
that
AZ
yielded
significant
acceleration
leaf
senescence.
Compared
to
control
group,
AZ‐treated
exhibited
faster
weight
loss,
higher
malondialdehyde
content,
greater
color
change,
chlorophyllase
activity.
Transcriptomic
widely
targeted
metabolomic
analyses
were
then
performed
samples.
investigation
disclosed
chlorophyll
degradation
genes
BraSGR2
BraPPH
upregulated
by
AZ,
leading
more
content.
effectively
stimulated
upregulation
senescence‐associated
(
BraSAG20
,
BraSAG21
BraSRG1
BraSRG2
),
thereby
accelerating
pace
process.
demonstrated
downregulated
flavonoid
synthase
BraFLS1
BraF3H
causing
a
relative
decline
levels.
study
also
unveiled
diminution
carbohydrate
content
storage,
further
exacerbated
AZ.
To
encapsulate,
our
preliminary
findings
suggest
application
accelerates
stored
choi,
which
helps
us
understand
relationship
between
demethylation
vegetable
Toxicology Research,
Год журнала:
2024,
Номер
13(4)
Опубликована: Июль 1, 2024
Abstract
As
an
element
with
metalloid
properties,
arsenic
is
pervasively
present
in
the
environment
and
recognized
as
a
potent
carcinogen.
Consequently,
issue
of
human
exposure
has
become
significant
concern
within
global
public
health
sector.
Numerous
studies
have
indicated
that
induces
cellular
senescence
through
various
mechanisms,
including
triggering
epigenetic
alterations,
inducing
senescence-associated
secretory
phenotype
(SASP),
promoting
telomere
shortening,
causing
mitochondrial
dysfunction.
This
article
collates
summarizes
latest
research
advancements
on
involvement
toxicity
explores
mechanisms
arsenic-induced
toxicity.
study
aims
to
provide
new
perspectives
directions
for
future
development
prevention
treatment
strategies.
Biomolecules,
Год журнала:
2024,
Номер
14(11), С. 1393 - 1393
Опубликована: Окт. 31, 2024
Chronic
kidney
disease
(CKD)
represents
a
significant
global
health
challenge,
affecting
millions
of
individuals
and
leading
to
substantial
morbidity
mortality.
This
review
aims
explore
the
epidemiology,
cardiovascular
complications,
management
strategies
associated
with
CKD,
emphasizing
importance
preventing
early
intervention.
CKD
is
primarily
driven
by
conditions
such
as
diabetes
mellitus,
hypertension,
diseases,
which
often
coexist
exacerbate
renal
impairment.
Effective
requires
multifaceted
approach,
including
lifestyle
modifications,
pharmacological
interventions,
regular
monitoring.
Dietary
changes,
sodium
restriction
controlled
intake
phosphorus
potassium,
play
vital
role
in
preserving
function.
Pharmacological
therapies,
particularly
angiotensin-converting
enzyme
(ACE)
inhibitors,
angiotensin
receptor
blockers
(ARBs),
emerging
agents
like
SGLT2
have
shown
efficacy
slowing
progression
improving
patient
outcomes.
Furthermore,
patients
undergoing
dialysis
face
increased
risk,
necessitating
comprehensive
address
both
cardiac
health.
As
landscape
treatment
evolves,
ongoing
research
into
novel
therapeutic
options
personalized
medical
approaches
are
essential.
underscores
urgent
need
for
awareness,
education,
effective
preventive
measures
mitigate
burden
enhance
quality
life
affected
individuals.
