The Role of Astrocytes in the Temporoammonic Pathway: Masticatory Behavior as a Neuroprotective Strategy Against Age-Related Cognitive Decline DOI Creative Commons
Micaele Maria Lopes Castro, Fabio Leite do Amaral, Fernando Mendes

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Abstract Astrocytes undergo phenotypic changes with aging, contributing to neurodegenerative diseases and cognitive impairments in later life. The temporoammonic (TA) pathway terminates at the stratum lacunosum-moleculare (SLM) of CA1 region, where astrocytic support is crucial for synaptic plasticity information processing related spatial learning memory. This study tested hypothesis that age-related morphological astrocytes SLM affect performance we explored whether masticatory activity modulates these changes. Young (6 months) aged (18 female Swiss albino mice were subjected three distinct regimens: a hard diet (HD), HD followed by soft (HD/SD), or SD return (HD/SD/HD). Cognitive was assessed using Morris Water Maze (MWM), rates calculated from escape latencies throughout five days trials. After behavioral testing, culled immunohistochemical analysis glial fibrillary acidic protein (GFAP) expression performed. 3D reconstructions within generated analyzed. Hierarchical clustering identified astrocyte morphotypes, revealing significant shift high-complexity (AST1) toward lower-complexity subtypes (AST2 AST3. results demonstrate aging reduces complexity, especially dorsal which correlated impaired Notably, on HD/SD/HD regimen exhibited partial recovery function morphology, suggesting potential rehabilitation effect activity. Statistical confirmed differences complexity across age groups dietary regimens (p < 0.01). These findings highlight may contribute decline. Overall, maintaining proper mastication be an effective approach maintain integrity during preserve hippocampus-dependent function, particularly older individuals.

Язык: Английский

Desenvolvimento sustentável e exercício físico: uma revisão integrativa DOI Open Access
Wellington Rui Andrade de Assis

Brazilian Journal of Health Review, Год журнала: 2025, Номер 8(1), С. e76880 - e76880

Опубликована: Янв. 17, 2025

Este estudo investiga a relação entre desenvolvimento sustentável e atividade física, ressaltando importância dos espaços públicos, como praças parques, para o bem-estar prática de exercícios. A crescente urbanização os desafios ambientais, agravados pelas mudanças climáticas, impactam saúde da população, resultando em aumento sobrepeso, obesidade doenças crônicas, especialmente grupos vulneráveis, crianças idosos. análise indica que disponibilidade áreas verdes está relacionada à redução violência ao evidenciando necessidade políticas públicas integradas considerem aspectos sociais, econômicos culturais. poluição do ar, material particulado, representa um problema sério afeta desproporcionalmente as populações exigindo intervenções melhorar qualidade ar acesso ambientes saudáveis. utilizou uma Revisão Integrativa Literatura, conforme fases metodológicas Souza et al. (2010), focando publicações 2022 2024. busca foi realizada nas bases dados Google Scholar, LILACS, MEDLINE, PubMed, Scielo ScienceDirect, 2.563.608 registros, quais 31 estudos foram selecionados. O manuscrito enfatiza públicos na promoção saúde, destacando sua correlação com física. Futuras pesquisas devem explorar interseção sustentabilidade incluindo baseadas natureza tecnologias, realidade virtual, promover hábitos saudáveis urbanos.

Процитировано

0
The Role of Astrocytes in the Temporoammonic Pathway: Masticatory Behavior as a Neuroprotective Strategy Against Age-Related Cognitive Decline DOI Creative Commons
Micaele Maria Lopes Castro, Fabio Leite do Amaral, Fernando Mendes

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Abstract Astrocytes undergo phenotypic changes with aging, contributing to neurodegenerative diseases and cognitive impairments in later life. The temporoammonic (TA) pathway terminates at the stratum lacunosum-moleculare (SLM) of CA1 region, where astrocytic support is crucial for synaptic plasticity information processing related spatial learning memory. This study tested hypothesis that age-related morphological astrocytes SLM affect performance we explored whether masticatory activity modulates these changes. Young (6 months) aged (18 female Swiss albino mice were subjected three distinct regimens: a hard diet (HD), HD followed by soft (HD/SD), or SD return (HD/SD/HD). Cognitive was assessed using Morris Water Maze (MWM), rates calculated from escape latencies throughout five days trials. After behavioral testing, culled immunohistochemical analysis glial fibrillary acidic protein (GFAP) expression performed. 3D reconstructions within generated analyzed. Hierarchical clustering identified astrocyte morphotypes, revealing significant shift high-complexity (AST1) toward lower-complexity subtypes (AST2 AST3. results demonstrate aging reduces complexity, especially dorsal which correlated impaired Notably, on HD/SD/HD regimen exhibited partial recovery function morphology, suggesting potential rehabilitation effect activity. Statistical confirmed differences complexity across age groups dietary regimens (p < 0.01). These findings highlight may contribute decline. Overall, maintaining proper mastication be an effective approach maintain integrity during preserve hippocampus-dependent function, particularly older individuals.

Язык: Английский

Процитировано

0