生物医学检测中常用氧化铁磁性纳米颗粒的生物适应性与毒性研究进展
Deleted Journal,
Год журнала:
2024,
Номер
1(2), С. 1 - 27
Опубликована: Фев. 26, 2024
氧化铁磁性纳米颗粒(IONPs)具有优越的理化性质，由于其在与检测分子结合后，可通过磁力进行简便的样品分离，并可通过表面增强拉曼散射(SERS)和顺磁性放大光学和核磁检测信号，在生物医学体外诊断领域应用广泛。随着生物医学诊断和治疗需求的发展，开发适用于体内环境的IONPs已成为未来该领域研究的主要方向，而这就首先需要考虑其在体的生物适应性与毒性问题。本文综述了生物医学检测中常用IONPs的体外毒性及影响因素、其对各主要器官和组织的在体毒性及在血液中相容性的相关研究，并讨论了相关研究中目前还存在的问题和挑战。希望通过本综述能够为IONPs在体检测应用的研究提供一些理论基础，助力IONPs材料在生物医学检测领域的进一步发展。
Single-domain magnetic particles with motion behavior under electromagnetic AC and DC fields are a fatal cargo in Metropolitan Mexico City pediatric and young adult early Alzheimer, Parkinson, frontotemporal lobar degeneration and amyotrophic lateral sclerosis and in ALS patients
Frontiers in Human Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Авг. 23, 2024
Metropolitan
Mexico
City
(MMC)
children
and
young
adults
exhibit
overlapping
Alzheimer
Parkinsons’
diseases
(AD,
PD)
TAR
DNA-binding
protein
43
pathology
with
magnetic
ultrafine
particulate
matter
(UFPM)
industrial
nanoparticles
(NPs).
We
studied
magnetophoresis,
electron
microscopy
energy-dispersive
X-ray
spectrometry
in
203
brain
samples
from
14
children,
27
adults,
ALS
cases/controls.
Saturation
isothermal
remanent
magnetization
(SIRM),
capturing
magnetically
unstable
FeNPs
̴
20nm,
was
higher
caudate,
thalamus,
hippocampus,
putamen,
motor
regions
subcortical
vs.
cortical
SIRM
MMC
≤
40y.
Motion
behavior
associated
exposures
25–100
mT
exhibited
IRM
saturated
curves
at
50–300
to
change
NPs
position
and/or
orientation
situ
.
Targeted
profiles
moving
under
AC/AD
fields
could
distinguish
controls.
Motor
neuron
accumulation
potentially
interferes
action
potentials,
ion
channels,
nuclear
pores
enhances
the
membrane
insertion
process
when
coated
lipopolysaccharides.
TEM
EDX
showed
7–20
nm
NP
Fe,
Ti,
Co,
Ni,
V,
Hg,
W,
Al,
Zn,
Ag,
Si,
S,
Br,
Ce,
La,
Pr
abnormal
neural
vascular
organelles.
Brain
of
particles
start
childhood
cytotoxic,
hyperthermia,
free
radical
formation,
motion
30–50
μT
(DC
fields)
are
critical
given
ubiquitous
electric
induce
damage.
Magnetic
UFPM/NPs
a
fatal
cargo
children’s
brains,
preventable
AD,
PD,
FTLD,
environmental
threat.
Billions
people
risk.
clearly
poisoning
ourselves.
Язык: Английский
Alzheimer’s, Parkinson’s, Frontotemporal Lobar Degeneration, and Amyotrophic Lateral Sclerosis Start in Pediatric Ages: Ultrafine Particulate Matter and Industrial Nanoparticles Are Key in the Early-Onset Neurodegeneration: Time to Invest in Preventive Medicine
Toxics,
Год журнала:
2025,
Номер
13(3), С. 178 - 178
Опубликована: Фев. 28, 2025
Billions
of
people
are
exposed
to
fine
particulate
matter
(PM2.5)
levels
above
the
USEPA’s
annual
standard
9
μg/m3.
Common
emission
sources
anthropogenic,
producing
complex
aerosolized
toxins.
Ultrafine
(UFPM)
and
industrial
nanoparticles
(NPs)
have
major
detrimental
effects
on
brain,
but
USA
does
not
measure
UFPM
a
routine
basis.
This
review
focuses
development
progression
common
neurodegenerative
diseases,
as
diagnosed
through
neuropathology,
among
young
residents
in
Metropolitan
Mexico
City
(MMC).
MMC
is
one
most
polluted
megacities
world,
with
population
22
million
residents,
many
whom
unaware
brain
caused
by
their
atmosphere.
Fatal
diseases
(such
Alzheimer’s
Parkinson’s)
that
begin
childhood
populations
living
air
environments
preventable.
We
conclude
UFPM/NPs
capable
disrupting
neural
homeostasis
give
rise
relentless
processes
throughout
entire
life
highly
MMC.
The
paradigm
reaching
old
age
neurodegeneration
no
longer
supported.
Neurodegenerative
changes
start
early
pediatric
ages
irreversible.
It
time
invest
preventive
medicine.
Язык: Английский
Sleep and Arousal Hubs and Ferromagnetic Ultrafine Particulate Matter and Nanoparticle Motion Under Electromagnetic Fields: Neurodegeneration, Sleep Disorders, Orexinergic Neurons, and Air Pollution in Young Urbanites
Toxics,
Год журнала:
2025,
Номер
13(4), С. 284 - 284
Опубликована: Апрель 8, 2025
Air
pollution
plays
a
key
role
in
sleep
disorders
and
neurodegeneration.
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
and/or
transactive
response
DNA-binding
protein
TDP-43
neuropathology
have
been
documented
children
young
adult
forensic
autopsies
the
metropolitan
area
of
Mexico
City
(MMC),
along
with
disorders,
cognitive
deficits,
MRI
brain
atrophy
seemingly
healthy
populations.
Ultrafine
particulate
matter
(UFPM)
industrial
nanoparticles
(NPs)
reach
urbanites’
brains
through
nasal/olfactory,
lung,
gastrointestinal
tract,
placental
barriers.
We
Fe
UFPM/NPs
neurovascular
units,
as
well
lateral
hypothalamic
nucleus
orexinergic
neurons,
thalamus,
medullary,
pontine,
mesencephalic
reticular
formation,
pinealocytes.
quantified
ferromagnetic
materials
arousal
hubs
examined
their
motion
behavior
to
low
magnetic
fields
MMC
autopsy
samples
from
nine
25
adults
AD,
PD,
neuropathology.
Saturated
isothermal
remanent
magnetization
curves
at
50–300
mT
were
associated
UFPM/NP
accumulation
sleep/awake
30–50
µT
(DC
fields)
exposure.
Brain
exposed
anthropogenic
PM
found
be
sensitive
fields,
behaviors
that
potentially
linked
early
development
progression
fatal
neurodegenerative
diseases
disorders.
Single-domain
orexin
system,
arousal,
sleep,
autonomic
regions,
are
neurodegeneration,
behavioral
impairment,
need
identify
higher
risk
monitor
environmental
UFPM
NP
emissions
exposures
fields.
Ubiquitous
ferrimagnetic
particles
field
threat
global
health.
Язык: Английский
Advances in Finite Element Analysis for Cancer Therapy Focusing on Magnetic Nanoparticle Hyperthermia
Multiscale Science and Engineering,
Год журнала:
2024,
Номер
6(2-3), С. 113 - 123
Опубликована: Июль 30, 2024
Язык: Английский
Recent Advancements and Clinical Aspects of Engineered Iron oxide Nanoplatforms for Magnetic Hyperthermia-induced Cancer Therapy
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101348 - 101348
Опубликована: Ноя. 21, 2024
Язык: Английский
Numerical study of magnetic nanoparticles injection into a brain tumor considering the effects of injection volume and location on the termination of cancerous cells
Biointerphases,
Год журнала:
2024,
Номер
19(6)
Опубликована: Ноя. 1, 2024
Lately,
magnetic
nanoparticle
(MNP)
hyperthermia
gained
much
attention
because
of
its
therapeutic
efficiency.
It
is
challenging
to
predict
all
the
treatment
parameters
during
actual
environment.
Hence,
numerical
approaches
can
be
utilized
optimize
various
interest.
In
present
research,
MNP
on
a
cancerous
tumor
placed
inside
human
brain
investigated
numerically
using
realistically
shaped
model
for
head
layers
and
tumor.
Applying
boundary
conditions,
steady-state
Pennes’s
bioheat
transfer
equation
solved
finite
element
method
scheme.
The
effects
injection
volume
location
thermal
distribution
are
examined
discussed
in
detail.
total
5990
mm3.
Three
different
volumes
per
point,
namely,
0.6,
1.2,
3
μl,
as
well
several
points,
performed.
observed
that
choosing
higher
number
points
affects
temperature
terms
uniformity.
contrast,
an
accurate
provides
lower
temperatures
tissue.
Moreover,
it
concluded
interfaces
between
anatomically
correct
play
critical
role
therapy.
Based
obtained
results,
optimal
condition
with
mm3
80
μl
through
20
over
considering
4
each
point.
Язык: Английский
Identifying in vitro toxicity testing approaches for (novel) proteins in the context of food and feed risk assessment
EFSA Supporting Publications,
Год журнала:
2024,
Номер
21(11)
Опубликована: Ноя. 1, 2024
Abstract
This
report
documents
the
outcomes
of
EFSA
procurement
(OC/EFSA/NIF/2022/01)
aimed
at
identifying
in
vitro
toxicity
testing
approaches
for
(novel)
proteins
context
food
and
feed
safety
assessment.
In
present
report,
we
an
integrated
strategy
evaluation
novel/toxic
proteins.
A
text‐mining
approach
was
used
to
create
a
literature
database
toxic
associated
with
retrieved
from
UniProt
KB
using
search
term
“Toxin
activity”.
It
shown
that
are
produced
by
relatively
limited
phylogenetic
subset,
including,
among
others,
bacteria,
insects,
serpents,
molluscs,
fungi.
Toxicological
effects
these
generally
conserved
within
groups.
Analysis
performed
GO
analysis
as
well
based
approach.
Relevant
tests
address
quantify
were
identified
evaluated
their
applicability
strategy.
stepwise
developed.
As
first
step,
initial
silico
prediction
is
carried
out
(Step
1).
followed
battery
assays
primary
mechanisms
2).
If
concern
arises
Step
2
tests,
use
relevant
model
systems
explore
potential
target
organ
required
3).
Knowledge
gaps
have
been
recommendations
provided
strategies,
particular
Some
involve
selection
integration
standardized,
digestion
reflective
passage
through
digestive
tract,
strategy,
thorough
assessment
suitability
new
methodologies
regulatory
To
accelerate
incorporation
NAMs
protein
safety,
case
studies
proof
concept
projects
needed
demonstrate
utility
effectiveness
strategies
Язык: Английский
Studies on the thermal sensitivity of lung cancer cells exposed to an alternating magnetic field and magnesium-doped maghemite nanoparticles
Cancer Nanotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 22, 2024
Abstract
Background
Magnetic
fluid
hyperthermia
(MFH)
represents
a
promising
therapeutic
strategy
in
cancer
utilizing
the
heating
capabilities
of
magnetic
nanoparticles
when
exposed
to
an
alternating
field
(AMF).
Because
efficacy
and
safety
MFH
treatments
depends
on
numerous
intrinsic
extrinsic
factors,
therefore,
proper
setups
should
focus
thermal
energy
dosed
into
cells.
Methods
In
this
study,
we
performed
experiments
using
human
lung
A549
cells
(in
vitro)
NUDE
Balb/c
mice
bearing
(A549)
vivo).
these
two
experimental
models,
heat
was
induced
by
magnesium-doped
iron(III)
oxide
coated
with
mPEG-silane
(Mg
0.1
-γ-Fe
2
O
3
(mPEG-silane)
0.5
)
AMF.
Results
We
observed
that
treated
Mg
(0.25
mg·mL
−1
magnetized
for
30
min
at
14.4
kA·m
yielded
satisfactory
outcome
reducing
cell
viability
up
ca.
21%
vitro).
The
activation
calculated
strength
estimated
349
kJ·mol
.
Both
volumetric
measurements
tumor
mass
assessments
confirmed
resonance
imaging
(MRI)
showed
superior
effect
injected
intratumorally
(3
subjected
AMF
(18.3
four
times
weekly
intervals.
Research
demonstrated
undergoing
exhibited
marked
suppression
growth
(V
=
169
±
94
mm
;
p
<
0.05)
comparison
control
group
untreated
mice.
CEM43
(cumulative
number
equivalent
minutes
43
°C)
value
were
9.6
specific
absorption
rate
(SAR)
level
ranging
from
100
150
W·g
Conclusions
as-obtained
results,
both
cytotoxic
those
related
calculations
SAR,
may
contribute
advancement
therapies,
concurrently
indicating
proposed
holds
great
potential
further
testing
context
medical
applications.
Graphical
Язык: Английский