A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS)

The Science of The Total Environment, Год журнала: 2025, Номер 960, С. 178240 - 178240

Опубликована: Янв. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Язык: Английский

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Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis

Environmental Research, Год журнала: 2021, Номер 201, С. 111632 - 111632

Опубликована: Июль 6, 2021

Язык: Английский

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Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(7), С. 3794 - 3794

Опубликована: Апрель 5, 2021

Poly- and perfluoroalkyl substances (PFAS) are manmade synthetic chemicals which have been in existence for over 70 years. Though they currently being phased out, their persistence the environment is widespread. There increasing evidence linking PFAS exposure to health effects, an issue of concern since such as perfluorooctane sulfonate (PFOS) perfluorooctanoic acid (PFOA) bioaccumulate humans, with a half-life Many epidemiological studies suggest that, worldwide, semen quality has decreased past several decades. One most worrying effects PFOS PFOA associations lower testosterone levels, similar clinical observations infertile men. This review thus focuses on PFOS/PFOA-associated male reproductive health. The sources drinking water listed. current increased lowered quality, from rodent supporting function endocrine disruptors system, exhibiting non-monotonic dose responses, noted. Finally, mechanisms action possible toxic Leydig, Sertoli, germ cells discussed. Future research efforts must consider utilizing better human model systems exposure, using more accurate susceptibility windows, improvements statistical modeling data account disruptor properties PFAS.

Язык: Английский

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Endocrine-Disrupting Chemicals and Child Health

The Annual Review of Pharmacology and Toxicology, Год журнала: 2021, Номер 62(1), С. 573 - 594

Опубликована: Сен. 23, 2021

While definitions vary, endocrine-disrupting chemicals (EDCs) have two fundamental features: their disruption of hormone function and contribution to disease disability. The unique vulnerability children low-level EDC exposures has eroded the notion that only dose makes thing a poison, requiring paradigm shift in scientific policy practice. In this review, we discuss as early fetal life provide an overview epidemiological studies on programming effects EDCs neuronal, metabolic, immune pathways well endocrine, reproductive, renal systems. Building accumulating evidence, dispel address existing myths about health with examples from child research. Finally, list effective actions reduce exposure subsequent harm are applicable individuals, communities, policy-makers.

Язык: Английский

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A Review on Removal and Destruction of Per- and Polyfluoroalkyl Substances (PFAS) by Novel Membranes

Membranes, Год журнала: 2022, Номер 12(7), С. 662 - 662

Опубликована: Июнь 27, 2022

Per- and Polyfluoroalkyl Substances (PFAS) are anthropogenic chemicals consisting of thousands individual species. PFAS consists a fully or partly fluorinated carbon-fluorine bond, which is hard to break requires high amount energy (536 kJ/mole). Resulting from their unique hydrophobic/oleophobic nature chemical mechanical stability, they highly resistant thermal, chemical, biological degradation. have been used extensively worldwide since the 1940s in various products such as non-stick household items, food-packaging, cosmetics, electronics, firefighting foams. Exposure may lead health issues hormonal imbalances, compromised immune system, cancer, fertility disorders, adverse effects on fetal growth learning ability children. To date, very few novel membrane approaches reported effective removing destroying PFAS. Therefore, this article provides critical review treatment removal by separation systems. We discuss recently techniques for include detailed discussion parameters affecting destruction. Moreover, an estimation cost analysis also included each technology. Additionally, technology still growing, we incorporated several future directions efficient treatment.

Язык: Английский

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