The Annual Review of Pharmacology and Toxicology,
Journal Year:
2021,
Volume and Issue:
62(1), P. 573 - 594
Published: Sept. 23, 2021
While
definitions
vary,
endocrine-disrupting
chemicals
(EDCs)
have
two
fundamental
features:
their
disruption
of
hormone
function
and
contribution
to
disease
disability.
The
unique
vulnerability
children
low-level
EDC
exposures
has
eroded
the
notion
that
only
dose
makes
thing
a
poison,
requiring
paradigm
shift
in
scientific
policy
practice.
In
this
review,
we
discuss
as
early
fetal
life
provide
an
overview
epidemiological
studies
on
programming
effects
EDCs
neuronal,
metabolic,
immune
pathways
well
endocrine,
reproductive,
renal
systems.
Building
accumulating
evidence,
dispel
address
existing
myths
about
health
with
examples
from
child
research.
Finally,
list
effective
actions
reduce
exposure
subsequent
harm
are
applicable
individuals,
communities,
policy-makers.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
271, P. 115939 - 115939
Published: Jan. 11, 2024
Although
previous
studies
have
shown
an
association
between
prenatal
exposure
to
perfluorinated
and
polyfluoroalkyl
substances
(PFAS)
neurodevelopmental
disorders
in
children,
the
results
been
inconsistent.
We
summarize
on
PFAS
neurodevelopment
children
order
better
understand
relationship.
conducted
a
meta-analysis
of
developmental
outcomes
associated
with
intellectual,
executive
function
behavioral
difficulty
explore
relationship
children.
searched
for
articles
published
up
August
3,
2023,
included
quantified
original
child
Intelligence
Quotient
(IQ),
during
pregnancy,
systematically
summarized
that
could
not
be
quantified.
There
is
evidence
sex-specific
children's
PIQ.
found
PFOS
[β
=
−1.56,
95%
CI
−2.96,
−
0.07;
per
1
ln
(ng/ml)
increase],
PFOA
−1.87,
−3.29,
0.46;
PFHxS
−2.02,
−3.23,
0.81;
increase]
decreased
performance
IQ
boys,
but
1.56,
0.06,
3.06;
increased
girls.
are
impairments
related
The Science of The Total Environment,
Journal Year:
2025,
Volume and Issue:
960, P. 178240 - 178240
Published: Jan. 1, 2025
This
review
follows
the
PRISMA
guidelines
to
provide
a
systematic
of
115
peer
reviewed
articles
that
used
non-targeted
analysis
(NTA)
methods
detect
per-
and
polyfluoroalkylated
substances
(PFAS).
literature
highlights
significant
positive
impact
NTA
in
understanding
PFAS
environment.
Within
geographical
bias
exists,
with
most
studies
(∼60
%)
conducted
United
States
China.
Future
other
regions
(such
as
South
America
Africa)
are
needed
gain
more
global
understanding.
More
research
is
required
marine
environments
atmosphere,
current
focus
mainly
on
freshwater,
groundwater,
soil,
sediments.
The
majority
measuring
environment,
rather
than
commercial
products
(with
exception
AFFF).
Non-lethal
blood
sampling
has
been
successful
for
humans
wildlife,
but
additional
biomonitoring
exposed
cohorts
understand
health
risks
biotransformation
pathways.
mostly
use
liquid
chromatography
negative
ionisation,
which
biases
towards
detection
specific
PFAS.
Despite
improvements
data
reporting
quality
assurance
control
(QA/QC)
procedures,
factors
such
false
rates
often
overlooked,
many
workflows
remain
highly
subjective.
Perfluoroalkyl
carboxylic
acids
(PFCAs)
perfluoroalkyl
sulfonic
(PFSAs)
detected
classes,
identified
over
80
%
studies,
common
routine
monitoring.
However,
our
>1000
from
total
382
different
300
classes
found
fewer
5
studies.
variety
present
limitations
relying
solely
targeted
methods.
monitoring
programs
regulations
would
benefit
considering
comprehensive
information
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(7), P. 3794 - 3794
Published: April 5, 2021
Poly-
and
perfluoroalkyl
substances
(PFAS)
are
manmade
synthetic
chemicals
which
have
been
in
existence
for
over
70
years.
Though
they
currently
being
phased
out,
their
persistence
the
environment
is
widespread.
There
increasing
evidence
linking
PFAS
exposure
to
health
effects,
an
issue
of
concern
since
such
as
perfluorooctane
sulfonate
(PFOS)
perfluorooctanoic
acid
(PFOA)
bioaccumulate
humans,
with
a
half-life
Many
epidemiological
studies
suggest
that,
worldwide,
semen
quality
has
decreased
past
several
decades.
One
most
worrying
effects
PFOS
PFOA
associations
lower
testosterone
levels,
similar
clinical
observations
infertile
men.
This
review
thus
focuses
on
PFOS/PFOA-associated
male
reproductive
health.
The
sources
drinking
water
listed.
current
increased
lowered
quality,
from
rodent
supporting
function
endocrine
disruptors
system,
exhibiting
non-monotonic
dose
responses,
noted.
Finally,
mechanisms
action
possible
toxic
Leydig,
Sertoli,
germ
cells
discussed.
Future
research
efforts
must
consider
utilizing
better
human
model
systems
exposure,
using
more
accurate
susceptibility
windows,
improvements
statistical
modeling
data
account
disruptor
properties
PFAS.
The Annual Review of Pharmacology and Toxicology,
Journal Year:
2021,
Volume and Issue:
62(1), P. 573 - 594
Published: Sept. 23, 2021
While
definitions
vary,
endocrine-disrupting
chemicals
(EDCs)
have
two
fundamental
features:
their
disruption
of
hormone
function
and
contribution
to
disease
disability.
The
unique
vulnerability
children
low-level
EDC
exposures
has
eroded
the
notion
that
only
dose
makes
thing
a
poison,
requiring
paradigm
shift
in
scientific
policy
practice.
In
this
review,
we
discuss
as
early
fetal
life
provide
an
overview
epidemiological
studies
on
programming
effects
EDCs
neuronal,
metabolic,
immune
pathways
well
endocrine,
reproductive,
renal
systems.
Building
accumulating
evidence,
dispel
address
existing
myths
about
health
with
examples
from
child
research.
Finally,
list
effective
actions
reduce
exposure
subsequent
harm
are
applicable
individuals,
communities,
policy-makers.
