International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12646 - 12646
Опубликована: Ноя. 25, 2024
The
widespread
use
of
polyvinyl
chloride
(PVC)
and
its
entry
into
humans
livestock
is
serious
concern.
In
our
study,
we
investigated
the
impact
PVC
treatments
on
physiological,
pathological,
hormonal,
microbiota
changes
in
female
rabbits.
Trend-like
alterations
weight
were
observed
spleen,
liver,
kidney
both
low
(P1)
high
dose
(P2)
treatment
groups.
Histopathological
examination
revealed
exfoliation
intestinal
mucosa
treated
groups
compared
to
control,
microplastic
particles
penetrated
embedded
spleen.
Furthermore,
P1
P2
showed
increased
17-beta-estradiol
(E2)
hormone
levels,
indicating
early
sexual
maturation.
Moreover,
elevated
tumor
necrosis
factor
alpha
(TNF-α)
levels
suggest
inflammatory
reactions
associated
with
treatment.
Genus-level
analyses
gut
group
several
genera
or
decreased
abundance.
conclusion,
significant
trend-like
correlations
demonstrated
between
content
feed
parameters.
To
knowledge,
this
first
study
investigate
broad-spectrum
effects
exposure
These
results
highlight
potential
health
risks
exposure,
warranting
further
investigations
animals
humans.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
279, С. 116499 - 116499
Опубликована: Май 27, 2024
There
are
various
substances
that
can
disrupt
the
homeostatic
mechanisms
of
body,
defined
as
endocrine-disrupting
chemicals
(EDCs).
The
persistent
nature
microplastics
(MPs)
is
a
cause
for
concern
due
to
their
ability
accumulate
in
food
chains
and
widespread
use,
making
toxic
effects
particularly
alarming.
potential
MPs
disrupting
endocrine
system
was
observed
multiple
tissues.
Moreover,
adrenal
gland
known
be
extremely
sensitive
EDCs,
while
with
effect
on
has
not
previously
been
studied.
This
study
aimed
highlight
polyethylene
(PE-MPs)
induced
adreno-toxic
rather
than
exploring
implicated
concluding
if
melatonin
(Mel)
afford
protection
against
PE-MPs
adreno-toxicity.
To
fulfill
goal,
six
groups
rats
were
used;
control,
Mel,
(3.75
mg/kg),
(15
mg/kg)
+Mel,
+Mel.
changes
cortex,
which
evident
by
increased
weight,
histopathological
examination,
ultrastructural
detected
electron
microscope.
A
reduction
serum
cortisol
an
increase
adrenocorticotropic
hormone
resulted
from
PE-MPs.
Mechanisms
may
include
steroidogenesis-related
genes,
drastically
reduce
mRNA
levels
StAR,
Nr0b1,
Cyp11A1,
well
Cyp11B1.
Also,
oxidative
stress
results
associated
higher
rates
lipid
peroxidation
decreased
superoxide
dismutase
glutathione.
inflammatory
illustrated
elevated
expression
IL-1β
NF-ķB,
immunohistochemical
staining,
addition
caspase-3
Bax,
markers
proapoptotic
activity.
impacts
relatively
dose-related,
dose
showing
more
significant
toxicity
lower
one.
Mel
treatment
substantial
amelioration
PE-MPs-induced
changes.
Collectively,
this
fills
knowledge
gap
about
MPs-induced
cortex
elucidates
related
mechanisms.
It
also
supports
Mel's
protective
activity
through
antioxidant,
anti-inflammatory,
anti-apoptotic,
gene
transcription
regulatory
effects.
Environmental Research,
Год журнала:
2024,
Номер
261, С. 119694 - 119694
Опубликована: Июль 27, 2024
Global
environmental
contamination
by
microplastics
(MPs)
is
a
growing
problem
with
potential
One
Health
impacts.
The
presence
of
MPs
in
vital
organs,
such
as
the
heart,
particular
concern,
but
knowledge
still
limited.
goal
present
pilot
study
was
to
investigate
heart
wild
specimens
three
commercial
fish
species
(Merluccius
merluccius,
Sardina
pilchardus,
and
Trisopterus
luscus)
from
North
East
Atlantic
Ocean.
Heart
samples
154
were
analysed
for
MP
content
(one
sample
per
fish).
A
total
44
recovered
species.
had
varied
chemical
composition
(5
polymers),
shapes
(4)
colours
(5).
Differences
profile
among
observed
(p
≤
0.05).
Thirty
(19%)
their
hearts,
mean
(±SD)
concentration
0.286
±
0.644
MPs/fish.
S.
pilchardus
highest
There
no
significant
>
0.05)
differences
between
M.
merluccius
T.
luscus.
These
findings
different
biological
ecological
traits
together
literature
data
suggest
that
likely
disseminated
phenomenon.
Therefore,
further
research
on
cardiovascular
system
its
health
effects
very
much
needed.
Environmental Science Processes & Impacts,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
study
highlights
the
negative
effects
of
PE
MPs
on
motor
functions,
oxidative
stress,
and
cellular
stress
responses
in
Drosophila
,
emphasizing
broader
ecological
risks
associated
with
microplastic
pollution.
International Journal of Environmental Health Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 40
Опубликована: Авг. 19, 2024
Microplastics
and
nanoplastics
(MNPs)
are
present
in
urban
dust
the
aquatic
environments
of
industrialized
cities.
MNPs
human
body
accumulate
lymphoid
follicles,
Peyer's
patches
gastrointestinal
tract,
pulmonary
vascular
endothelial
cells,
which
slowly
result
toxicity.
Since
previous
studies
introduced
curcumin
as
a
natural
protective
agent
against
environmental
toxins,
we
reviewed
preclinical
that
had
used
to
protect
organs
or
cells
from
toxicity
secondary
exposure
MNPs.
It
was
found
resulted
osteolysis,
immunotoxicity,
thyroid
disturbances,
nephrotoxicity,
neurotoxicity,
hepatotoxicity,
toxicity,
cardiovascular
especially
endocrine,
reproductive
Nevertheless,
except
for
one
study
reviewed,
restored
all
oxidative
histopathological
damages
induced
by
normal
due
curcumin's
inherent
antioxidant,
antiapoptotic,
anti-inflammatory,
anti-proliferative
properties.
JURNAL INFO KESEHATAN,
Год журнала:
2024,
Номер
22(2), С. 347 - 356
Опубликована: Июнь 30, 2024
Polyethylene
(PE)
becomes
a
source
of
microplastics
that
can
be
widely
distributed
through
the
digestive
and
respiratory
systems.
However,
its
effects
on
blood
cells
are
still
being
investigated.
This
study
aims
to
analyze
impact
Microplastic
(PE-MPs)
exposure
female
rats,
including
erythrocytes,
leukocytes,
platelets.
used
Wistar
which
were
divided
into
control
PE-MP
groups.
was
administered
via
whole-body
inhalation
at
concentration
15
mg/m³
for
4
hours
daily
28
days.
The
absorption
plastic
particles
detected
in
human
bloodstream
is
likely
occur
mucosal
contact
(either
ingestion
or
inhalation).
After
period,
rats
euthanized
collect
samples
heart.
A
complete
count
performed
using
an
automatic
hematology
analyzer,
morphology
analyzed
thin
smears.
Mann-Whitney
test.
increased
erythrocyte
platelet
counts
without
corresponding
rise
leukocytes.
Erythrocytes
showed
abnormal
(12.73%
with
ovalocytes
tear-shaped
cells).
Erythrocyte
indices
(MCV,
MCH,
MCHC)
no
significant
differences.
Platelet
rose
by
1.7%
(p-value=
0.017).
Leukocyte
neutrophil
lower
(0.84
0.94
times
lower,
respectively),
while
lymphocytes
monocytes
higher
(1.03
1.61
higher,
respectively)
group
compared
controls.
neutrophil-to-lymphocyte
ratio
did
not
differ
significantly.
disrupts
parameters,
altering
increasing
counts.
Potential
causes
include
oxidative
stress,
immune
responses,
compensatory
mechanisms.
Study
limitations
small
sample
size
exclusive
focus
exposure.
Integrating
multiple
routes
(inhalation,
ingestion,
dermal)
could
offer
broader
view
microplastic
impacts.
Future
research
larger
samples,
diverse
doses
durations,
exploration
additional
markers
organ-specific
crucial
understanding
toxicity
real-world
scenarios.
JURNAL INFO KESEHATAN,
Год журнала:
2024,
Номер
22(3), С. 494 - 501
Опубликована: Сен. 30, 2024
Plastic
is
a
synthetic
or
semi-synthetic
organic
polymer
that
widely
used
in
daily
life
and
industrial
production.
Microplastics
are
widespread
contaminants
can
enter
the
human
body
through
consumption
of
foods
containing
microplastics,
inhalation
microplastics
air,
skin
contact
with
microplastic
particles
present
products.
ovaries
as
foreign
bodies
cause
inflammation,
oxidative
stress,
even
ovarian
granulosa
cell
death.
Polyethylene
plastic
shards
generally
have
higher
ability
to
absorb
environmental
toxins
than
other
types
plastic.
Polyvinyl
chloride
(PVC)
one
oldest
thermoplastic
polymers
often
water
pipes.
PVC
has
carcinogenic
monomers
some
harmful
additives.
This
study
aims
determine
effect
subacute
exposure
micro-nanoplastics
per
on
SOD
MDA
levels
rat
ovaries.
The
research
method
true
experimental
design
Randomize
Post
Test
Only
Group
Design
design.
organs
female
white
rats
had
been
exposed
PE
for
28
days.
number
samples
this
amounted
18
rats.
Subacute
lower
significantly
increase
expected
provide
knowledge
an
overview
future
mechanism
toxicity
micro-nanoplastic
impact
infertility
free
radicals
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12646 - 12646
Опубликована: Ноя. 25, 2024
The
widespread
use
of
polyvinyl
chloride
(PVC)
and
its
entry
into
humans
livestock
is
serious
concern.
In
our
study,
we
investigated
the
impact
PVC
treatments
on
physiological,
pathological,
hormonal,
microbiota
changes
in
female
rabbits.
Trend-like
alterations
weight
were
observed
spleen,
liver,
kidney
both
low
(P1)
high
dose
(P2)
treatment
groups.
Histopathological
examination
revealed
exfoliation
intestinal
mucosa
treated
groups
compared
to
control,
microplastic
particles
penetrated
embedded
spleen.
Furthermore,
P1
P2
showed
increased
17-beta-estradiol
(E2)
hormone
levels,
indicating
early
sexual
maturation.
Moreover,
elevated
tumor
necrosis
factor
alpha
(TNF-α)
levels
suggest
inflammatory
reactions
associated
with
treatment.
Genus-level
analyses
gut
group
several
genera
or
decreased
abundance.
conclusion,
significant
trend-like
correlations
demonstrated
between
content
feed
parameters.
To
knowledge,
this
first
study
investigate
broad-spectrum
effects
exposure
These
results
highlight
potential
health
risks
exposure,
warranting
further
investigations
animals
humans.
