Difenoconazole
(DFZ)
is
a
typical
triazole
fungicide,
which
widely
used
in
agricultural
production,
but
residues
of
DFZ
the
environment
pose
serious
hazard
to
non-target
organisms.
Ferulic
acid
(FA)
phenolic
compound
with
pharmacological
activities
such
as
antioxidant
and
anti-inflammatory.
The
purpose
this
study
was
investigate
hepatic
damage
carp
mechanism
action
FA
alleviating
tissue
induced
by
exposure
carp.
It
discovered
that
improved
liver
carp's
capability
decreased
accumulation
ROS
tissue.
Meanwhile,
controlled
transcriptional
levels
inflammation-related
factors
prevented
inflammatory
response
brought
on
NF-κB
signaling
pathway.
Additionally,
TUNEL
results
demonstrated
beginning
apoptosis,
whereas
dietary
supplementation
reduced
protein
expression
Bax
Cytochrome
C
(Cyt
c)
apoptosis-related
genes,
increased
Bcl-2.
In
conclusion,
protects
against
injury
modulating
oxidative
damage,
inflammation
apoptosis.
Ecotoxicology and Environmental Safety,
Год журнала:
2023,
Номер
267, С. 115674 - 115674
Опубликована: Ноя. 1, 2023
The
incidence
of
diabetes
mellitus
(DM)
is
gradually
increasing,
making
it
a
widespread
global
health
concern.
Cadmium
(Cd)
common
toxic
heavy
metal
in
the
environment,
and
cadmium
exposure
may
be
associated
with
diabetic
nephropathy
(DN).
However,
mechanism
Cd-induced
DN
remains
unclear.
In
this
study,
we
aimed
to
determine
effect
on
kidney
injury
underlying
rats
renal
tubular
epithelial
cell
line
(NRK-52E
cells).
Our
results
could
provide
novel
insights
nephrotoxic
cadmium.
HE,
PAS,
Masson
staining
were
used
observe
pathological
injury.
COL-I,
COL-IV,
CTSB,
CTSD
protein
levels
detected
by
immunohistochemistry
western
blotting.
Immunofluorescence
was
detect
fluorescence
intensity
p62
LC3
proteins
tissue.
TEM
ultrastructure
mitochondria
number
autophagosomes.
After
exposure,
DM
showed
dramatic
decrease
body
weight
compared
unexposed
group.
Relative
contrasting
trend
after
exposure.
Urinary
microalbumin/creatinine
significantly
increased
normal
clearer
groups
than
control
groups.
Endogenous
creatinine
clearance
exhibited
trend.
rats,
MDA
content
GSH,
CAT,
SOD,
GSH-PX
activation
reduced
controls.
Pathological
damage
more
pronounced,
expression
autophagy
related
apoptosis
fibrosis
higher
vivo
vitro
cadmium-exposed
Further,
lysosomal
lower,
ROS
autophagosome
count
exposed
Therefore,
aggravates
via
inhibition.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
This
study
delves
into
the
adverse
effects
of
AVM,
emphasizing
oxidative
stress
induction
in
Chinese
mitten
crab,
Erocheir
sinensis,
and
role
MAPK-CncC
signaling
pathway
mediating
antioxidative
response.
Our
findings
reveal
a
dose-dependent
impairment
growth
performance,
alongside
occurrence
stress.
The
activity
CAT
superoxide
dismutase
increased
significantly
all
treatments
(0.2,
2,
20
μg/L)
while
lipid
peroxidation
level
rose
median
(2
high
(20
concentration
groups.
T-AOC
levels
decreased
reactive
oxygen
species
significantly.
Transcriptomic
insights
indicated
activation
pathway,
critical
upregulating
genes
associated
with
detoxification
defense.
Knocking
down
CncC,
homologue
vertebrate
Nrf2
gene,
by
dsRNA
E.
sinensis
resulted
down-regulation
reduced
survival
tolerance
to
AVM
exposure.
By
using
an
vitro
cell
culture
system,
we
observed
similar
downregulations
when
hepatopancreas
cells
were
treated
ML385,
CncC
specific
inhibitor.
Moreover,
rapid
phosphorylation
JNK
protein
was
upon
When
inhibited,
more
vulnerable
AVM-induced
robust
expression
gene
blocked.
Applied In Vitro Toxicology,
Год журнала:
2025,
Номер
11(1), С. 16 - 20
Опубликована: Фев. 20, 2025
Introduction:
Abamectin
(ABA)
is
an
insecticide
that
commonly
used
in
agricultural
spraying.
Although
it
known
to
have
neurotoxic
effects
on
living
organisms
the
ecosystem
and
humans,
details
of
these
effects,
including
duration
amount
exposure,
are
not
fully
understood.
The
aim
this
study
evaluate
effect
ABA
exposure
human
microglia
clone
3
(HMC3)
cells.
These
cells
were
chosen
because
they
suitable
for
modeling
immunological
functions
such
as
cytokine
production,
cell
migration,
inflammation
response.
