The
present
study
was
carried
out
on
the
quantification
of
heavy
metals
cadmium,
lead,
copper,
chromium,
nickel
and
zinc
in
bivalve
mollusk
concha
prieta
(Anadara
tuberculosa)
using
technique
inductively
coupled
plasma
optical
emission
spectroscopy
ICP-OES.
research
aims
to
identify
whether
bioaccumulated
content
exceeds
maximum
limits
established
by
various
public
health
bodies
such
as
ONU,
FAO,
Codex
Alimentarius,
EEC
NHI.
Samples
species
were
collected
randomly
from
three
locations
Puerto
El
Morro,
Playas
Municipal
Market
La
Libertad
Seafood
Gulf
Guayaquil.
Thirty-three
soft
tissue
samples
Anadara
tuberculosa
evaluated,
values
quantified
mg/kg
follow
following
order
relation
mean
Zn>Cu>Cd>Ni>Cr>Pb.
Atmosphere,
Год журнала:
2025,
Номер
16(2), С. 225 - 225
Опубликована: Фев. 17, 2025
Cadmium
(Cd)
is
a
pervasive
environmental
and
industrial
toxin
that
poses
significant
health
risks.
It
readily
moves
through
soil–plant
systems,
leading
to
global
contamination
human
exposure
diet,
smoking,
pollution.
The
main
purpose
of
this
review
explore
the
effect
Cd
on
physiological
processes
different
bodies’
organs,
including
bones,
kidneys,
liver,
as
well
immune,
cerebrovascular,
cardiovascular,
reproductive
systems.
Accumulation
in
body
can
result
poisoning
with
severe
impacts
bone
kidney
health,
reduced
mineral
density
due
renal
damage.
Research
has
linked
lung
cancer
pulmonary
toxicity,
elevated
urinary
biomarkers
suggest
compromised
function.
also
affects
immune
systems;
liver;
contributing
various
diseases
by
disrupting
blood
pressure
calcium
regulation,
causing
oxidative
stress
DNA
damage,
impairing
cell
functions.
Ongoing
research
essential
fully
understand
Cd-induced
toxicological
effects
develop
effective
interventions
prevent
mitigate
Cell Death and Disease,
Год журнала:
2024,
Номер
15(6)
Опубликована: Июнь 6, 2024
Abstract
In
chronic
kidney
disease
(CKD),
renal
fibrosis
is
an
unavoidable
result
of
various
manifestations.
However,
its
pathogenesis
not
yet
fully
understood.
Here,
we
revealed
the
novel
role
Homeobox
D10
(HOXD10)
in
CKD-related
fibrosis.
HOXD10
expression
was
downregulated
vitro
and
vivo
models.
UUO
model
mice
were
administered
adeno-associated
virus
(AAV)
containing
HOXD10,
overexpression
plasmids
introduced
into
human
proximal
tubular
epithelial
cells
induced
by
TGF-β1.
The
levels
iron,
reactive
oxygen
species
(ROS),
lipid
ROS,
oxidized
glutathione/total
glutathione
(GSSG/GSH)
ratio,
malonaldehyde
(MDA),
superoxide
dismutase
(SOD)
determined
using
respective
assay
kits.
Treatment
with
AAV–HOXD10
significantly
attenuated
dysfunction
inhibiting
NOX4
transcription,
ferroptosis
pathway
activation,
oxidative
stress.
High
activation
profibrotic
gene
TGF-β1/erastin
(a
agonist)
abrogated
HK-2
cells.
Moreover,
bisulfite
sequencing
PCR
that
showed
a
hypermethylated
level
TGF-β1-treated
binding
to
promoter
confirmed
chromatin
immunoprecipitation
(ChIP)
analysis
dual-luciferase
reporter
assays.
Targeting
may
represent
innovative
therapeutic
strategy
for
treatment
CKD.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 15, 2024
Diabetes
and
its
complications
significantly
affect
individuals’
quality
of
life.
The
etiology
diabetes
mellitus
associated
is
complex
not
yet
fully
understood.
There
an
increasing
emphasis
on
investigating
the
effects
endocrine
disruptors
diabetes,
as
these
substances
can
impact
cellular
processes,
energy
production,
utilization,
ultimately
leading
to
disturbances
in
homeostasis.
Mitochondria
play
a
crucial
role
generation,
any
impairment
organelles
increase
susceptibility
diabetes.
This
review
examines
most
recent
epidemiological
pathogenic
evidence
concerning
link
between
including
complications.
analysis
suggests
that
disruptor-induced
mitochondrial
dysfunction—characterized
by
disruptions
electron
transport
chain,
dysregulation
calcium
ions
(Ca
2+
),
overproduction
reactive
oxygen
species
(ROS),
initiation
signaling
pathways
related
apoptosis—may
be
key
mechanisms
connecting
development
Processes,
Год журнала:
2025,
Номер
13(1), С. 168 - 168
Опубликована: Янв. 9, 2025
This
study
was
aimed
at
extracting,
characterizing,
and
exploring
the
detoxification
activity
of
peptide-containing
polysaccharide
from
Agaricus
balchaschensis.
An
anion
adsorption
fraction
acquired
through
hot
water
extraction.
Its
structure
analyzed,
potential
protective
effect
against
cadmium-intoxicated
mice
explored.
Structural
analysis
revealed
that
principal
component
A.
balchaschensis
(ABPCP)
is
polysaccharide,
which
consists
glucose,
mannose,
galactose,
xylose,
containing
(1
→
4)-linked
α-D-glucan,
3)-linked
β-D-Glcp,
6)-linked
β-D-Manp,
β-D-Galp,
β-D-xylan.
The
amino
acid
content
ABPCP
11.747
mg/g.
Threonine,
serine,
glutamate,
glycine,
alanine,
cysteine,
valine,
methionine,
lysine,
arginine
were
detected
in
ABPCP,
among
glutamate
highest.
alleviating
on
cadmium
poisoning
investigated.
significantly
reduced
serum
heart,
kidneys,
liver,
indicates
could
promote
discharge.
also
decreased
nitric
oxide,
endothelin-1,
urea,
uric
acid,
creatinine,
kidney
liver
damage
caused
by
cadmium.
All
these
results
manifest
can
lower
organs
alleviate
to
kidneys
livers
damaged
Cd.
Toxics,
Год журнала:
2025,
Номер
13(2), С. 129 - 129
Опубликована: Фев. 10, 2025
Cadmium
(Cd)
is
an
important
environmental
pollutant
that
can
enter
the
body
and
inflict
kidney
damage.
Quercetin
(Que)
a
natural
flavonoid
compound
alleviate
damage
in
Cd-treated
rats,
but
specific
mechanism
unclear.
Herein,
24
male
Sprague-Dawley
rats
were
divided
into
four
groups,
namely
control,
Cd,
Cd
+
Que,
Que
groups.
Four
weeks
later,
anesthetized
with
ether
euthanized;
then,
their
blood
was
collected
kidneys
removed.
Renal
function
markers
measured.
Kidney
tissue
structure
observed
by
HE
staining,
cell
apoptosis
detected
TUNEL
method,
mRNA
protein
expression
levels
IRE1α-XBP1
signaling
pathway
analyzed
RT-PCR
Western
blotting.
Results
showed
treatment
group
exhibited
decreased
renal
dysfunction
pathologic
injury.
Cd-induced
significantly
increased
(p
<
0.01)
related
to
pathway.
Compared
group,
dysfunction.
Conversely,
decreased,
of
IRE1α
XBP1
0.01).
inflicted
Therefore,
restore
caused
through
inhibition
he
present
study
was
conducted
to
quantify
the
heavy
metals
cadmium,
lead,
copper,
chromium,
nickel,
and
zinc
in
bivalve
mollusk
concha
prieta
(Anadara
tuberculosa)
using
in-
ductively
coupled
plasma
optical
emission
spectroscopy
(ICP-OES).
This
research
aims
identify
whether
bioaccumulate
content
of
exceeds
maximum
limits
established
by
various
public
health
bodies
such
as
ONU,
FAO,
Codex
Alimentarius,
EEC,
NHI.
Samples
species
were
collected
randomly
from
three
locations
Puerto
El
Morro,
Playas
Municipal
Market,
La
Libertad
Seafood
Market
Gulf
Guayaquil.
Thirty-three
soft
tissue
samples
evaluated,
values
quantified
mg/kg
following
order:
Zn>Cu>Cd>Ni>Cr>Pb.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 14, 2024
Heavy
metals,
ubiquitous
in
the
environment,
pose
a
global
public
health
concern.
The
correlation
between
these
and
diabetic
kidney
disease
(DKD)
remains
unclear.
Our
objective
was
to
explore
heavy
metal
exposures
incidence
of
DKD.
We
analyzed
data
from
NHANES
(2005-2020),
using
machine
learning,
cross-sectional
survey.
study
also
involved
bidirectional
two-sample
Mendelian
randomization
(MR)
analysis.
Machine
learning
reveals
coefficients
-0.5059
-
0.6510
for
urinary
Ba
Tl
with
DKD,
respectively.
Multifactorial
logistic
regression
implicates
Ba,
Pb,
blood
Cd,
Pb
as
potential
associates
When
adjusted
all
covariates,
odds
ratios
95%
confidence
intervals
are
0.87
(0.78,
0.98)
(p
=
0.023),
0.70
(0.53,
0.92)
0.012),
0.53
(0.34,
0.82)
0.005),
0.76
(0.64,
0.90)
0.002)
order.
Furthermore,
multiplicative
interactions
Sb,
Cd
Co,
Hg
might
be
present.
Among
population,
OR
DKD
is
mere
0.10,
95%CI
(0.01,
0.74),
Co
0.73
(0.54,
Model
3,
0.72
(0.55,
0.95)
2.
Restricted
Cubic
Splines
(RCS)
indicate
linear
linkage
general
population
among
diabetics.
An
observable
trend
effect
present
MR
analysis
1.16
(1.03,
1.32)
0.018)
1.17
(1.00,
1.36)
0.044)
Mn,
In
demonstrates
nonlinear
inverse
association
whereas
displays
relationship
