The
European
Rapid
Alert
System
for
Food
and
Feed
(RASFF)
has
shown
1133
notifications
spices
herbs
in
the
last
10
years
(2013–2023).
analysis
of
these
indicated
that
58.7%
(665
alerts)
alerts
corresponded
to
chemical
hazards.
Mycotoxins
corresponding
aflatoxin
B1
(24
ochratoxin
A
(39
were
found
19.4%
samples.
Due
presence
biological
hazards
foodstuffs,
comprehensive
knowledge
their
molecular
mechanisms
action
is
required
as
part
risk
assessment
strategy.
Aflatoxin
(AFB1)
a
known
potent
carcinogen
been
linked
liver
cancer
humans
animals.
Its
toxic
effects
consist
forming
DNA
adducts,
causing
mutations,
interfering
with
cellular
processes.
On
other
hand,
(OTA)
be
nephrotoxic,
hepatotoxic,
carcinogenic,
immunosuppressive
both
OTA
targets
kidneys
liver,
exerting
its
similarly
AFB1,
i.e.,
through
damage,
oxidative
stress,
interference
This
communication
reviews
mechanism
underlying
toxicity
AFB1
Europe,
focusing
on
biosynthesis,
toxicodynamics,
interaction
components,
resulting
biochemical
pathways
leading
adverse
health
effects.
Moreover,
it
discusses
potential
strategies
mitigating
spices,
emphasizing
importance
hazard
characterization
effective
management
regulation.
Food Chemistry,
Год журнала:
2024,
Номер
465, С. 142036 - 142036
Опубликована: Ноя. 13, 2024
The
interaction
between
dietary
bioactive
compounds
and
mycotoxins
in
food
safety
is
crucial
due
to
the
potential
health
risks
raised
by
protective
functions
of
substances.
This
study
focused
on
red
beetroot
(Beta
vulgaris),
a
rich
source
polyphenols
betalains,
incorporated
into
daily
consumption
such
as
bread,
examine
its
effects
bioavailability
using
an
vitro
Caco-2
cell
model.
investigates
how
these
affect
mycotoxins,
specifically
ochratoxin
A
(OTA),
aflatoxin
B1
(AFB1),
zearalenone
(ZEA),
which
are
known
compromise
intestinal
barrier
function
nutrient
absorption.
Additionally,
bioaccesibility
total
betalains
(betacyanins
betaxanthins)
(TBC)
(TPC)
content
was
evaluated.
beetroot-enriched
breads
were
subjected
digestion
process,
followed
transepithelial
transport
assay
assess
differentiated
cells.
Results
indicate
increase
TBC
TPC
(up
99
%
27
%,
respectively)
during
digestion,
suggesting
enhanced
absorption
against
mycotoxin-induced
damage.
presence
bread
increased
with
complex
interactions
observed,
particularly
triple
mycotoxin's
combination.
results
highlight
components
mycotoxins'
bioavailability,
underlining
importance
further
research
their
mechanisms
action
applications
nutrition.
Photonics,
Год журнала:
2023,
Номер
11(1), С. 9 - 9
Опубликована: Дек. 22, 2023
Ochratoxin
A
(OTA),
which
is
highly
toxic
and
carcinogenic,
easily
produced
in
cereal
crops,
dry
herbs,
other
foods
under
improper
storage.
Traditional
detection
methods,
including
high-performance
liquid
chromatography
(HPLC)
enzyme-linked
immunosorbent
assay
(ELISA),
can
detect
OTA
accurately,
but
there
are
many
problems
such
as
long
period,
high
cost,
poor
reproducibility.
Therefore,
developing
a
rapid,
non-destructive,
sensitive
method
for
essential.
In
this
paper,
we
used
surface
plasmon
resonance
(SPR)
biosensor
combined
with
terahertz
(THz)
spectroscopy
to
quantify
OTA.
As
result,
the
concentration
range
of
acetonitrile
solution
was
up
0–20
pg/μL,
limit
1
meet
requirements
most
foods.
Further,
applied
black
tea,
pg/mg,
500
times
higher
than
UV
spectrophotometry,
completely
meets
EU
regulations.
This
study
shows
that
combination
an
SPR
promising
approach
achieve
simple,
low-cost
trace
substance
quantification
drugs.
The
European
Rapid
Alert
System
for
Food
and
Feed
(RASFF)
has
shown
1133
notifications
spices
herbs
in
the
last
10
years
(2013–2023).
analysis
of
these
indicated
that
58.7%
(665
alerts)
alerts
corresponded
to
chemical
hazards.
Mycotoxins
corresponding
aflatoxin
B1
(24
ochratoxin
A
(39
were
found
19.4%
samples.
Due
presence
biological
hazards
foodstuffs,
comprehensive
knowledge
their
molecular
mechanisms
action
is
required
as
part
risk
assessment
strategy.
Aflatoxin
(AFB1)
a
known
potent
carcinogen
been
linked
liver
cancer
humans
animals.
Its
toxic
effects
consist
forming
DNA
adducts,
causing
mutations,
interfering
with
cellular
processes.
On
other
hand,
(OTA)
be
nephrotoxic,
hepatotoxic,
carcinogenic,
immunosuppressive
both
OTA
targets
kidneys
liver,
exerting
its
similarly
AFB1,
i.e.,
through
damage,
oxidative
stress,
interference
This
communication
reviews
mechanism
underlying
toxicity
AFB1
Europe,
focusing
on
biosynthesis,
toxicodynamics,
interaction
components,
resulting
biochemical
pathways
leading
adverse
health
effects.
Moreover,
it
discusses
potential
strategies
mitigating
spices,
emphasizing
importance
hazard
characterization
effective
management
regulation.
