Manganese overexposure results in ferroptosis through the HIF-1α/p53/SLC7A11 pathway in ICR mouse brain and PC12 cells
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
279, С. 116481 - 116481
Опубликована: Май 23, 2024
Manganese
(Mn)
overexposure
has
been
associated
with
the
development
of
neurological
damage
reminiscent
Parkinson's
disease,
while
underlying
mechanisms
have
yet
to
be
fully
characterized.
This
study
aimed
investigate
leading
injury
in
dopaminergic
neurons
induced
by
Mn
and
identify
novel
treatment
approaches.
In
vivo
vitro
models,
ICR
mice
neuron-like
PC12
cells
were
exposed
Mn,
respectively.
We
treated
them
anti-ferroptotic
agents
ferrostatin-1
(Fer-1),
deferoxamine
(DFO),
HIF-1α
activator
dimethyloxalylglycine
(DMOG)
inhibitor
LW6.
also
used
p53-siRNA
verify
mechanism
Mn-induced
neurotoxicity.
Fe
concentrations
increased
brains
overexposed
Mn.
Additionally,
Mn-exposed
exhibited
movement
impairment
encephalic
pathological
changes,
decreased
HIF-1α,
SLC7A11,
GPX4
proteins
p53
protein
levels.
Fer-1
protective
effects
against
both
behavioral
biochemical
changes.
Consistently,
vitro,
exposure
caused
ferroptosis-related
changes
levels,
all
ameliorated
Fer-1.
Upregulation
DMOG
alleviated
Mn-associated
ferroptosis,
LW6
exacerbated
neurotoxicity
through
downregulating
HIF-1α.
knock-down
rescued
ferroptosis
without
altering
expression.
resulted
neurons,
mediated
HIF-1α/p53/SLC7A11
pathway.
Язык: Английский
Role of manganese in brain health and disease: focus on oxidative stress
Free Radical Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Nutritional Support of Chronic Obstructive Pulmonary Disease
Péter Simon,
É Török,
Klára Szalontai
и другие.
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1149 - 1149
Опубликована: Март 26, 2025
Background:
COPD
is
a
heterogenous
disease
of
the
respiratory
tract
caused
by
diverse
genetic
factors
along
with
environmental
and
lifestyle-related
effects
such
as
industrial
dust
inhalation
and,
most
frequently,
cigarette
smoking.
These
lead
to
airflow
obstruction
chronic
symptoms.
Additionally,
increased
risk
infections
exacerbates
airway
inflammation
in
patients.
As
consequence
complex
pathomechanisms
difficulty
treatment,
among
leading
causes
mortality
both
western
countries
developing
world.
Results:
The
management
still
challenge
for
clinicians;
however,
alternative
interventions
smoking
cessation
lifestyle
changes
from
sedentary
life
moderate
physical
activity
special
attention
diet
may
ameliorate
patients'
health.
Here,
we
reviewed
different
dietary
components
supplements
on
conditions
COPD.
Conclusions:
patients
are
continuously
exposed
heavy
metals,
which
commonly
present
smoke
polluted
air.
Meanwhile,
they
often
experience
significant
nutrient
deficiencies,
affect
detoxification
these
toxic
metals.
This
turn
can
further
disrupt
nutritional
balance
interfering
absorption,
metabolism,
utilization
essential
micronutrients.
Therefore,
awareness
deliberate
efforts
should
be
made
check
levels
micronutrients,
ensuring
adequate
antioxidants,
vitamin
D,
K2,
magnesium,
iron,
particularly
important
reducing
development
limiting
severity.
Язык: Английский
GLUT1 Maintains Esophageal Cancer Stem Cell-like Characteristics by Inhibiting Autophagy-dependent Ferroptosis via EGFR
Experimental Cell Research,
Год журнала:
2025,
Номер
unknown, С. 114600 - 114600
Опубликована: Май 1, 2025
Язык: Английский
The role of circHmbox1(3,4) in ferroptosis-mediated cognitive impairments induced by manganese
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
476, С. 135212 - 135212
Опубликована: Июль 15, 2024
Язык: Английский
Research progress on metal pollutants inducing neurotoxicity through ferroptosis
Journal of Zhejiang University (Medical Sciences),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
It
has
been
confirmed
that
exposure
to
various
metal
pollutants
can
induce
neurotoxicity,
which
is
closely
associated
with
the
occurrence
and
development
of
neurological
disorders.
Ferroptosis
a
form
cell
death
in
response
pollutant
it
related
oxidative
stress,
iron
metabolism
lipid
peroxidation.
Recent
studies
have
revealed
ferroptosis
plays
significant
role
neurotoxicity
induced
by
metals
such
as
lead,
cadmium,
manganese,
nickel,
antimony.
Lead
triggers
through
disorder
inflammation.
Cadmium
ion
metabolism,
stress
signaling
pathways
IRE1/JNK/FTH1.
Manganese
promote
mitochondrial
dysfunction,
stress.
Nickel
influencing
function,
disrupting
homeostasis
facilitating
peroxidation
central
nervous
system.
Antimony
glutathione
depletion
activating
autophagy,
resulting
excessive
intracellular
deposition
ultimately
causing
ferroptosis.
This
article
reviews
effects
on
ferroptosis-related
indicators
discusses
specific
mechanisms
each
may
provide
references
identify
targets
preventing
develop
treatment
strategies
Язык: Английский