Research progress on metal pollutants inducing neurotoxicity through ferroptosis DOI
Zhiqiang Qin, Yuqing Chen, Xinyuan Zhao

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

It has been confirmed that exposure to various metal pollutants can induce neurotoxicity, which is closely associated with the occurrence and development of neurological disorders. Ferroptosis a form cell death in response pollutant it related oxidative stress, iron metabolism lipid peroxidation. Recent studies have revealed ferroptosis plays significant role neurotoxicity induced by metals such as lead, cadmium, manganese, nickel, antimony. Lead triggers through disorder inflammation. Cadmium ion metabolism, stress signaling pathways IRE1/JNK/FTH1. Manganese promote mitochondrial dysfunction, stress. Nickel influencing function, disrupting homeostasis facilitating peroxidation central nervous system. Antimony glutathione depletion activating autophagy, resulting excessive intracellular deposition ultimately causing ferroptosis. This article reviews effects on ferroptosis-related indicators discusses specific mechanisms each may provide references identify targets preventing develop treatment strategies

Language: Английский

Manganese overexposure results in ferroptosis through the HIF-1α/p53/SLC7A11 pathway in ICR mouse brain and PC12 cells DOI Creative Commons
Jian Chen,

Zehua Tao,

Xinyu Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116481 - 116481

Published: May 23, 2024

Manganese (Mn) overexposure has been associated with the development of neurological damage reminiscent Parkinson's disease, while underlying mechanisms have yet to be fully characterized. This study aimed investigate leading injury in dopaminergic neurons induced by Mn and identify novel treatment approaches. In vivo vitro models, ICR mice neuron-like PC12 cells were exposed Mn, respectively. We treated them anti-ferroptotic agents ferrostatin-1 (Fer-1), deferoxamine (DFO), HIF-1α activator dimethyloxalylglycine (DMOG) inhibitor LW6. also used p53-siRNA verify mechanism Mn-induced neurotoxicity. Fe concentrations increased brains overexposed Mn. Additionally, Mn-exposed exhibited movement impairment encephalic pathological changes, decreased HIF-1α, SLC7A11, GPX4 proteins p53 protein levels. Fer-1 protective effects against both behavioral biochemical changes. Consistently, vitro, exposure caused ferroptosis-related changes levels, all ameliorated Fer-1. Upregulation DMOG alleviated Mn-associated ferroptosis, LW6 exacerbated neurotoxicity through downregulating HIF-1α. knock-down rescued ferroptosis without altering expression. resulted neurons, mediated HIF-1α/p53/SLC7A11 pathway.

Language: Английский

Citations

6
Role of manganese in brain health and disease: focus on oxidative stress DOI
Airton C. Martins, Gustavo H. Oliveira‐Paula, Alexey A. Tinkov

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Nutritional Support of Chronic Obstructive Pulmonary Disease DOI Open Access

Péter Simon,

É Török,

Klára Szalontai

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1149 - 1149

Published: March 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Language: Английский

Citations

0
The role of circHmbox1(3,4) in ferroptosis-mediated cognitive impairments induced by manganese DOI
Shengtao Wei, Xiaoli Ma,

Guiqiang Liang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135212 - 135212

Published: July 15, 2024

Language: Английский

Citations

3
Research progress on metal pollutants inducing neurotoxicity through ferroptosis DOI
Zhiqiang Qin, Yuqing Chen, Xinyuan Zhao

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

It has been confirmed that exposure to various metal pollutants can induce neurotoxicity, which is closely associated with the occurrence and development of neurological disorders. Ferroptosis a form cell death in response pollutant it related oxidative stress, iron metabolism lipid peroxidation. Recent studies have revealed ferroptosis plays significant role neurotoxicity induced by metals such as lead, cadmium, manganese, nickel, antimony. Lead triggers through disorder inflammation. Cadmium ion metabolism, stress signaling pathways IRE1/JNK/FTH1. Manganese promote mitochondrial dysfunction, stress. Nickel influencing function, disrupting homeostasis facilitating peroxidation central nervous system. Antimony glutathione depletion activating autophagy, resulting excessive intracellular deposition ultimately causing ferroptosis. This article reviews effects on ferroptosis-related indicators discusses specific mechanisms each may provide references identify targets preventing develop treatment strategies

Language: Английский

Citations

0