Involvement of SIRT1-mediated aging in liver diseases
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 20, 2025
Liver
disease
is
a
significant
global
health
issue,
responsible
for
millions
of
deaths
annually.
Aging,
characterized
by
the
gradual
decline
in
cellular
and
physiological
functions,
impairs
tissue
regeneration,
increases
susceptibility
to
liver
diseases,
leads
health.
Silent
information
regulator
1
(SIRT1),
NAD⁺-dependent
deacetylase,
has
emerged
as
pivotal
factor
modulating
age-related
changes
liver.
SIRT1
preserves
function
regulating
essential
aging-related
pathways,
including
telomere
maintenance,
epigenetic
modifications,
senescence,
intercellular
communication,
inflammation,
mitochondrial
function.
Notably,
levels
naturally
with
age,
contributing
progression
increased
vulnerability
injury.
This
review
summarizes
regulatory
role
aging
its
impact
on
diseases
such
fibrosis,
alcoholic
associated
(ALD),
metabolic
dysfunction-associated
steatotic
(MASLD),
steatohepatitis
(MASH),
hepatocellular
carcinoma
(HCC).
We
also
discuss
emerging
therapeutic
approaches,
activators,
gene
therapy,
nutritional
interventions,
which
are
evaluated
their
potential
restore
mitigate
progression.
Finally,
we
highlight
future
research
directions
optimize
SIRT1-targeted
therapies
clinical
applications
conditions.
Язык: Английский
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119400 - 119400
Опубликована: Янв. 1, 2025
Язык: Английский
Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Urolithin B as a renoprotective agent against 5-fluorouracil-induced nephrotoxicity: role of Nrf2/Keap1/HO-1, SIRT1/FOXO3, and NF-кB/TNF-α signaling pathways
Food and Chemical Toxicology,
Год журнала:
2024,
Номер
195, С. 115129 - 115129
Опубликована: Ноя. 22, 2024
Язык: Английский
Sitagliptin regulates the AMPK/NF-κB signaling pathway to alleviate lipopolysaccharide-induced inflammatory responses and promote osteogenic differentiation in rat bone marrow mesenchymal stem cells
Archives of Oral Biology,
Год журнала:
2025,
Номер
unknown, С. 106253 - 106253
Опубликована: Апрель 1, 2025
This
study
aimed
to
explore
the
impact
of
sitagliptin
on
inflammatory
response
and
osteogenic
differentiation
in
lipopolysaccharide
(LPS)-stimulated
rat
bone
marrow
mesenchymal
stem
cells
(BMSCs)
clarify
underlying
mechanisms
action.
In
vitro-cultured
BMSCs
were
identified,
treated
with
a
range
doses,
assessed
cell
counting
kit-8
assay
quantify
viability.
The
expression
proteins
genes
relevant
inflammation
osteogenesis
was
measured
using
enzyme-linked
immunosorbent
real-time
quantitative
polymerase
chain
reaction
techniques.
ability
analyzed
by
alkaline
phosphatase
staining,
activity
assay,
alizarin
red
s
staining.
Adenosine
monophosphate-activated
protein
kinase
(AMPK)/nuclear
factor-kappa
B
(NF-κB)
signaling
pathway
activation
detected
through
western
blotting.
High
but
not
low
concentrations
significantly
suppressed
cellular
Sitagliptin
dose-dependently
inhibited
LPS-induced
responses
while
facilitating
their
differentiation.
It
also
activated
AMPK
suppressing
NF-κB
activity.
inhibitor
treatment
partially
reversed
these
beneficial
effects
osteogenesis.
suppresses
promoting
modulation
AMPK/NF-κB
activity,
thereby
mitigating
functional
impairment
under
microenvironmental
conditions.
Язык: Английский
Hepatoprotective Effects of Dandelion against AFB1-induced Liver Injury are Associated with Activation of Bile Acid-FXR Signaling in Chicks
Toxicon,
Год журнала:
2025,
Номер
unknown, С. 108419 - 108419
Опубликована: Май 1, 2025
Язык: Английский
Is castration leading to biological aging in dogs? Assessment of lipid peroxidation, inflammation, telomere length, mitochondrial DNA copy number, and expression of telomerase and age-related genes
BMC Veterinary Research,
Год журнала:
2024,
Номер
20(1)
Опубликована: Окт. 24, 2024
Biological
aging
is
a
complex
process
influenced
by
various
factors,
including
reproductive
status
and
castration.
This
study
aimed
to
evaluate
the
impact
of
castration
on
biological
in
dogs.
Fifteen
male
crossbred
dogs
were
randomly
divided
into
sham-operation
control
group
(n
=
5)
castrated
10).
Blood
samples
collected
at
weeks
0,
4,
8,
12,
16,
18
post-surgery.
Malondialdehyde
(MDA
as
indicator
Lipid
peroxidation),
C-reactive
protein
(as
an
inflammation),
telomere
length,
mitochondrial
DNA
(mtDNA)
copy
number,
expression
age-related
(P16,
P21,
TBX2)
telomerase-related
(TERT)
genes
assessed
blood
samples.
Plasma
MDA
levels
higher
16
18,
while
CRP
only
week
18.
Telomere
length
mtDNA
number
lower
Gene
analysis
showed
that
P16
was
8
P21
TERT
TBX2
The
TBX2/P16
ratio
but
TBX2/P21
did
not
differ
between
groups.
Castration
appears
have
protective
effect
against
dogs,
evidenced
lipid
peroxidation,
inflammation,
changes
gene
expression.
Язык: Английский